Lucas is hoping to buy a "
pibble" now? I don't know...Kiwibros, if we get anywhere that thing we won't be cocky for long. Let's hope that this is yet another larp like his therapy sessions or how he was totally going to ditch his Twitch partnership. /Our cat/, Nigga Ma'am, must be protected and kept safe from poorly trained guard dogs at all costs.
To add more to the DIY HRT disaster discussion:
Some of you already covered some of the potential adverse effects associated with taking these drugs in isolation and why a doctor must be involved at every step of the "treatment" process. Another thing to consider are the
possible drug interactions these substances may have with medications that these kids may already be taking. It is probably a safe bet to say that a lot of these young boys have already been diagnosed with
psychiatric conditions (ranging from anxiety to affective or even psychotic disorders) for which they have been prescribed a variety of common
psychotropic drugs as part of their treatment.
Some of these interactions might
increase (as is the case with
estradiol OR medroxyprogesterone when taken concomitantly fluvoxamine, an antidepressant sold under the brand name "Luvox") or
decrease (
see estradiol with lamotrigine, a medication sometimes used in the treatment of bipolar disorder)
blood plasma concentrations of one of the involved medications, resulting in an
increased likelihood/severity of certain side effects or reducing a medications' effectiveness despite the dose being within a typically therapeutic range.
Other interactions are more serious, especially those that involve
drugs that are known to prolong the QT interval. Excessive QT prolongation can predispose the myocardium to the development of early after-depolarisations, which in turn can trigger re-entrant tachycardias such as
Torsades de Pointes (which can lead to
sudden cardiac death).
You might have recognised that a whole bunch of common psych meds were listed in the "Drug Induced QT Prolongation" article I posted (1st and 2nd gen antipsychotics, SSRIs, SNRIs and the less common ol' tricyclics).
If you go visit
Otokonoko Pharmaceuticals' product page, you will also see that some of the products listed, such as:
domperidone (an antiemetic + promotility agent that seems to be popular with the kids because it can cause gynecomastia and galactorrhea, aka: little mommy milkers) and
bicalutamide (actual FDA approved titty skittles) that are
also known to have an potentially effect of prolonging the QT interval.
The
co-administration of a common SSRI, citalopram (Celexa) with bicalutamide is contraindicated since doing so may result in additive effects and an increased risk of ventricular arrhythmias including torsade de pointes and sudden death. Similar warnings come with other psychotropic medications like
haloperidol and citalopram's (S)-enantiomer,
escitalopram.
All the more reason to consult with a trained physician and to avoid dealing with seedy online vendors who likely picked up their wares off the back of a truck or procured them from some a dodgy compounding pharmacy in India or some shit.
