Anyone who says that puberty blockers are completely safe and leave no sequalae is full of it. The most
honest answer would be that we simply
do not know and that the children who are having their puberty artificially delayed indefinitely are the sacrificial lamb for this crazy madness.
I have a hunch (though I could be wrong) that the "decades of research" concerning long acting gonadotropin-releasing hormone (GnRH) analogues that trans activists like to refer to, examined the effects of drugs like
Leuprorelin (Lupron) in the treatment of children who were diagnosed with
Central Precocious Puberty (CPP). Even though (GnRH) analogues are toted as the "gold standard" in the treatment of CPP and are thought to have few serious side effects in the short term, researchers acknowledge that there is a paucity of data on all of the potential side effects.
One thing that is worth noting is the difference in the duration of treatment. In children CPP, medication is administered to
temporarily halt precocious puberty (
before 8 years in girls and 9 years in boys) until the child reaches a more chronologically appropriate age, that is to say, the age at which most children can expect to normally begin puberty. There is no strong clinical evidence for the optimal time to stop pubertal blockade for CPP and so guidelines for the cessation of treatment haven't really been standardized.
Most clinicians will withdraw treatment and allow puberty to resume around the time the child reaches the median age (
10.5 years of age in girls; 12 years of age in boys) for pubertal onset and in
nearly all cases before the 95th percentile age (14 in girls and in boys). The decision will be influenced by current height, predicted final height, the degree of bone age advancement, the aetiology of precocious puberty and the child's and family’s views, in consultation. In most cases, it can take up to year for a child to get back on the "puberty train" post treatment withdrawal.
Using the median age of puberty onset as a guide, children being treated for CPP will only be on the blockers for a 2~4 years at most. They then go on to resume puberty as they normally would along side their peers. Compare this to advocates who argue that children be put on puberty blockers before puberty begins until they are old enough to commence cross hormone treatment (16~18 years of age). Again, at best we can hazard a guess as to what this means for a child's development but we do not know. To insist otherwise would be disingenuous.