URETHRAL STRICTURES
[A urethral stricture involves scarring that narrows the tube that carries urine out of your body (urethra). A stricture restricts the flow of urine from the bladder and can cause a variety of medical problems in the urinary tract, including inflammation or infection]
Urethral strictures occur with
an incidence between 25% to 58%; 41% of strictures occur in the anastomotic urethra between pars fixa and pars pendulans, 28% occur in the phallic urethra, 15% occur in the meatus, 13% occur in the fixed urethra, and 8% occur in multiple urethral segments, with most strictures presenting in association with fistulas. A majority of strictures occur at anastomotic sites with poor blood flow due to ischemia. Contracture of neourethral tissue during healing can also lead to stricture formation.
Urethral strictures often require surgery but
can be temporized with catheter dilation until the inflammation surrounding the tissue has abated.
Endoscopic management with dilation or direct visualization internal urethrotomy is a reasonable, less-invasive, first-line treatment option for short, single strictures. These techniques are performed under direct endoscopic or radiographic guidance to ensure the proper location is dilated or incised.
Placement of a Foley catheter for at least 2 weeks postoperatively allows for urinary drainage to promote healing. Self-catheterization or selfcalibration techniques can be used after catheter removal to help maintain urethral patency.
Durable success after endoscopic management is low, with the rate of recurrence as high as 88% likely due to the lack of a corpus spongiosum and poor blood supply.
Urethral reconstruction via urethroplasty is the best option for definitive management of strictures. Techniques after neophallus construction include meatotomy and excision and primary anastomosis, free graft urethroplasty, pedicled flap urethroplasty, and 2-stage urethroplasty. In the largest study to date on outcomes after urethroplasty following phalloplasty, meatotomy and 2-staged urethroplasty had the
lowest recurrence rates, at 25% and 30.3%, respectively. Perineal urethrostomy is reserved for patients with multiple failed reconstructive attempts or those who choose to avoid extensive reconstruction.
Extended meatotomy is the standard approach for surgically correcting short stenotic segments at the meatus. This technique is performed by incising the meatus with a simple ventral incision and then reapproximating the inner urethral mucosa and glanular tissue with sutures. Meatoplasty is performed for recurrent or longer meatal strictures. It includes numerous techniques that may incorporate flaps or grafts and can be performed in a single or staged procedure similar to more proximal urethral reconstruction. The Asopa urethroplasty is a 1-stage technique that involves ventral sagittal urethrotomy and dorsal graft placement without mobilization of the urethra. A single-stage ventral onlay BMG (Buccal Mucosa Graft) is another distal urethroplasty technique. A double-face BMG technique that involves opening the stenosed segment ventrally and raising glanular wings for placement of a ventral graft followed by a dorsal urethrotomy incision for placement of a dorsal graft is another option.
A more novel technique that involves a ventral transurethral wedge resection of the stenosed segment and transurethral delivery and spread fixation of appropriate BMG inlay into the resultant urethrotomy may be applied as well. Augmented staged surgeries are important for patients with a completely obliterated meatus or those with prior failures
(Fig. 11).
Fig. 11. Distal meatal reconstruction in a patient with prior extended meatotomy.
(A) Buccal mucosa inlay placed dorsally prior to tubularization.
(B) Postoperative image immediately after tubularization.
For a primary short urethral anastomotic stricture, a single-stage anastomotic technique without the use of additional flaps or grafts is an option. Excision and primary anastomosis or a nontransecting anastomotic urethroplasty, which is considered the gold standard approach for short strictures in cisgender male urethras, may be performed when a short anastomotic stricture is accompanied by reliable well-vascularized local tissue. This technique is performed by excising the stenosed urethral segment, spatulating the proximal and distal stumps in opposite, complementary directions, and then reapproximating the edges over an indwelling Foley catheter.
The overall success rate in this population is low, at 57%, which may be due to decreased tissue mobility, absence of corpus spongiosum, and reduced blood supply in transgender men with neophallic urethras.
A staged urethroplasty is the recommended option for long penile or recurrent neourethral strictures
(Figs. 12 and 13). This technique begins with a ventral urethrotomy through the stenosed segment or, in cases of total neourethral obliteration, a complete ventral spatulation of the anterior urethral segment. The urethral plate either is then augmented with a graft or a new neourethral plate is created with a graft. The lateral edges of the urethral plate are then sutured to the borders of the skin incision and left to heal exposed. As the urethral plate matures over the next 3 months to 6 months, the patient voids through a temporary, more proximal urethrostomy. During the second stage, the lateral edges of the urethral plate are mobilized prior to tubularization of the neourethra over a catheter. Overall, this technique has been reported to
have a success rate of up to 70%, which is the highest success rate among all types of neophallic urethroplasties.
Fig. 12. Staged urethroplasty of anastomotic stricture.
(A) Stage 1 repair with BMG placed at the site of anastomotic stricture to serve as a temporary perineal urethrostomy.
(B) Matured urethral plate at 6 months postoperatively.
(C) Intraoperative image during stage 2 urethroplasty showing lateral mobilization of urethral plate and tubularization over a Foley catheter.
(D) Stage 2: immediate postoperative image.
Fig. 13. Staged urethroplasty for panurethral stricture.
(A) Preoperative RUG and VCUG showing a completely obliterated pars pendulans.
(B) Intraoperative image showing absence of neourethra.
(C) Stage 1: reharvested BMG fixation in multiple mosaic pieces in a patient with a prior bilateral BMG harvest.
(D) Stage 2: mobilization of urethral plate 6 months later (note additional lingual mucosa inlay placed to widen the distal plate).
(E) Stage 2: tubularization of the urethra over a Foley catheter.
(F) Postoperative image at 8 months.
Perineal urethrostomy is an alternate option for patients who are not interested in reconstructive surgery or who have failed multiple reconstructive efforts. In other situations, it may be used as a temporary treatment until definitive reconstruction is pursued. This surgery results in
a perineal urethra under the neoscrotum by opening the fixed urethra and approximating the lateral edges of the urethra to the perineum. It allows for unobstructed urine flow from the newly created urethra.