Wuhan Coronavirus: Megathread - Got too big

[Drain Todger]

@borsabil @Lichen Bark

I've just been thinking; SARS-CoV-2 Spike is thought to bind integrins.

The Spike Glycoprotein of SARS-CoV-2 Binds to β1 Integrins Expressed on the Surface of Lung Epithelial Cells - PubMed

The spike glycoprotein attached to the envelope of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to and exploits angiotensin-converting enzyme 2 (ACE2) as an entry receptor to infect pulmonary epithelial cells. A subset of integrins that recognize the arginyl-glycyl-aspartic...

pubmed.ncbi.nlm.nih.gov

A potential role for integrins in host cell entry by SARS-CoV-2

www.ncbi.nlm.nih.gov

COVID-19 is known to cause come very unusual reductions in CD4+ and CD8+ cell counts.

Apoptosis-induced T-cell lymphopenia is related to COVID-19 severity - PubMed

Increased levels of acute-phase reactants and lymphopenia are predictors of disease severity in coronavirus disease 2019 (COVID-19). This study aimed to investigate the role of apoptosis in the etiology of lymphopenia in patients with COVID-19. This multicentered, prospective, and case-control...

pubmed.ncbi.nlm.nih.gov

CD4+T, CD8+T counts and severe COVID-19: A meta-analysis

www.ncbi.nlm.nih.gov

What if the Spike in the vaccines is somehow directly affecting T and B lymphocytes through their integrins? It shouldn't, if it's locked in the prefusion conformation, but what if it is, somehow?

First oral antiviral for COVID-19, Lagevrio (molnupiravir), approved by MHRA

The antiviral was found to be safe and effective following a stringent review of the available evidence.

www.gov.uk

Comments on Twitter claiming thats ivermectin plus some crap to get to charge 1000 dollars per pill

@Drain Todger

How much is true please senpai enlighten me. Because last time i checked it was dangerous mutagen that increases chances for cancer

Basically all true, except for the cancer part. Not sure about that.

All antivirals for COVID-19 have the same exact problem; most people who aren't hospitalized don't need them, because their symptoms will resolve without incident. Practically all people who are hospitalized for COVID-19 have been symptomatic for 5+ days and are well beyond the point where antivirals are no longer effective at all, because there's no more virus.

The best time to take antivirals is immediately after suspected exposure, or immediately after symptoms develop, whichever is recognized first.

Again, the reason why Ivermectin, HCQ, Kaletra, and Remdesivir were never shown conclusively to work is because the majority of the trials enrolled people who were already 8 to 10 days post-exposure, at the bottom of the viral replication curve. That is, the treatment was futile.

Basically any antiviral should provide at least modest effectiveness if taken prophylactically. These patented antivirals are all rip-offs. This is generally reflected by the data, which makes a strong case for early treatment:

https://ivmmeta.com/

COVID-19 early treatment: real-time analysis of 1,475 studies

COVID-19 early treatment: real-time analysis of 1,475 studies

c19early.com

I think there's a strong case to be made for a COVID-19 therapy cocktail that achieves the following things:

• Block calcium ion channels.
• Block histamine.
• Chelate iron.
• Inhibit xanthine oxidase.
• Inhibit NADPH oxidase.
• Inhibit MPO.
• Inhibit oxidation of arachidonic acid into isoprostanes.
• Inhibit cytokines.
• Scavenge ROS.
• Activate Nrf2.
• Raise nitric oxide levels.

Basically, amlodipine, famotidine, deferoxamine, allopurinol or colchicine or probenecid, apocynin or APX-115, indomethacin, dexamethasone, budesonide, fluvoxamine, melatonin, NAC, intravenous vitamin C, dimethyl fumarate, and iNO therapy along with dietary nitrate, arginine, and citrulline supplementation. I think this combo could rescue someone from the brink pretty quick. Possibly. Indomethacin seems like a weird choice, I know, since COX inhibitors tend to promote coagulation, but it has been repurposed for COVID-19 with success, and it actually prevents the iron-mediated oxidation of AA into highly inflammatory isoprostanes. I have very little doubt that this is occurring, given that COVID-19 is said to involve a bradykinin storm, and bradykinin upregulates the COX/AA pathway, and if this is occurring alongside lots of oxidative stress, isoprostanes will be the result. It's basically confirmed that COVID-19 causes severe lipid peroxidation. All the signs are there. Highly elevated ROS biomarkers. Nitrotyrosine, 4-HNE, Malondialdehyde, ferroptosis signatures in the tissues, etc.

 

[helloAhole$]

OSHA FAQ if that regulation link is still not working. Link

Spoiler: Don't start dooming yet

We still have next week to see if they still plan on tripling down and start processing out the feds. Plus for a lot of you unless they decide to quadruple down it isn't that bad.

If you don't live in a blue state and a state worker OSHA can't enforce do to some agreement in the FAQ, so a plan for the quadruple.
If you work for a franchise you will be good on that as long as the franchisee has less than 100. If you work for a hiring agency you won't be added to the numbers of the business, so if under 100 you better ask for a big thank you. There were more exemptions, but don't remember them. Just remember your most likely shitty low paying (hope that part gets better) job is safe.

You also have the nice choice of swabbing, can be done all in house, and or jabbing, so don't ruin it.
So since everything is more or less in house your employer can figure out how to cut the corners or you can go with a fake card which I am sure that would make them liable and they probably are not going to want to pay that fee much like the one for not complying. Also if you are on a work from home or other form of long distancing no swab needed.
If you are allowed to use BinaxNow depending given they are required to keep records the FAQ didn't say anything about it not being pictures. The card stock seems as a dry erase marker would easily work if you and your boss is willing to go down that route, them or a medical personnel are required to "monitor", and the coloration of a negative really doesn't seem to change over time. I have 1 I checked after use and compared to a 3 week one no noticeable difference.

Spoiler: If you want to doom

The rug was pulled up from under federal employees pretty last minute when they most likely got pissy. So if enough business cause a fuss you may get to enjoy the same. They are giving a time on at the bottom noting 6 months for this plan to work (only 2 weeks guys trust the plan). So not suggesting anything, but it may not be worth raising hell unless they try going even harder into this before then and hope the courts don't fuck things up two much till then, but I have no clue.

So all are aware if not once the regulation reaches time for comments they do allow them online and believe last I was in there it was .pdf form. So have fun if you want I am sure a lot of people have founds some interesting reads from this thread.

Spoiler: I know

it ain't going to do shit. Also don't have archive account pdf best I can do tell being arsed to create another account online.

 

[Drain Todger]

If SARS-CoV-2 Spike is integrated into the genome permanently and continually expressed by somatic cells through LINE-1 retrotransposons, then the antidote is SiRNAs to silence it. Not only that, unless the gene were cut out and removed from people's genome, they would need to keep taking SiRNAs indefinitely to keep it silenced.

Small interfering RNA - Wikipedia

en.wikipedia.org

Jesus Christ. This is so fucking weird. When Baked Alaska's buddy Mike "Tokes" Coudrey contacted me over a year ago, he kept yammering on about SiRNAs and how he was investing heavily in them as the "next big thing".

Holy fuck, who gave him that stock tip?

 

[NoReturn]

OSHA vax rule just landed

View attachment 2687905

Businesses have until after the holidays to implement Biden Covid vaccine mandate

The newly released Labor Department rules apply to businesses with 100 or more employees.

www.cnbc.com

Biden vaccine mandate: Businesses have until after Christmas to comply

archived 4 Nov 2021 12:52:44 UTC

archive.ph

• Delayed until after the new year, starts Jan 4th
• Employees who aren't vaxed must pay for a weekly covid test starting Jan 4th
• Employees who aren't vaxed must wear a mask at all times starting Dec 5th

Reminder: OSHA probably doens't have the legal authority to do this

And any rule changes like this require public commentary period + 6 months or somesuch to implement

(aka, he's as full of shit as his diapers)

In a couple months you'll start to see lawyers taking wrongful dismissal cases for refusing the Fauci ouchie. I'm going to let them fire me, collect unemployment and then sue when the opportunity comes up.

Napkin-math tells me it will only take 208 Kiwirounds to retain a lawyer. Seems like a good investment.

Good thing I listen to this before reading about Biden's mandate to cushion my mood for the rest of the day.

This one's mine:

 

[The Wicked Mitch]

If SARS-CoV-2 Spike is integrated into the genome permanently and continually expressed by somatic cells through LINE-1 retrotransposons, then the antidote is SiRNAs to silence it. Not only that, unless the gene were cut out and removed from people's genome, they would need to keep taking SiRNAs indefinitely to keep it silenced.

Small interfering RNA - Wikipedia

en.wikipedia.org

Jesus Christ. This is so fucking weird. When Baked Alaska's buddy Mike "Tokes" Coudrey contacted me over a year ago, he kept yammering on about SiRNAs and how he was investing heavily in them as the "next big thing".

Holy fuck, who gave him that stock tip?

View attachment 2689076

This sounds an awful lot like financial advice, dropping a fat stack on Alnylam tomorrow.

If it works out I'll buy you a hand crafted set of Murmillo equipment.

 

[Clockwork_PurBle]

I'm assuming the jab numbers for my uni are very low or at least "low" by certain standards. I'm assuming this because in my weekly newsletter email I saw a headline for a free t-shirt giveaway. Cool, I love t-shirts. Oh wait no it's free t-shirts that say "DON'T WAIT. VACCINATE." on it.

So now I will wait in the coming weeks to see how many of these I see on campus. I know dudes will wear just about anything they got for free so I will keep that in mind as well.

 

[Nate Higgs]

I'm assuming the jab numbers for my uni are very low or at least "low" by certain standards. I'm assuming this because in my weekly newsletter email I saw a headline for a free t-shirt giveaway. Cool, I love t-shirts. Oh wait no it's free t-shirts that say "DON'T WAIT. VACCINATE." on it.

So now I will wait in the coming weeks to see how many of these I see on campus. I know dudes will wear just about anything they got for free so I will keep that in mind as well.

claim a bunch and donate them to the homeless

 

[Lorne Armstrong]

WTF is that? Some might be really desesperate to use Sesame Street characters to talk about Covid and vaccines.

What questions do your kids have about the Covid-19 vaccine?

Join Big Bird, Elmo and Rosita for "The ABCs of Covid Vaccines: A CNN/Sesame Street Townhall for Families" this Saturday at 8:30 a.m. ET, hosted by CNN's Dr. Sanjay Gupta and Erica Hill.

www.cnn.com

There's some replies on Gettr about this who gived me a small chuckle.

Bobby Levy on GETTR: This Saturday at 8:30am, CNN will be hosting a Town Hall with Sesame Street where they will be answering user submitted questions about the COVID-19 Vaccine. https://www.cnn.com/2021/11/02/us/sesame-street-covid-town-hall-questio

This Saturday at 8:30am, CNN will be hosting a Town Hall with Sesame Street where they will be answering user submitted questions about the COVID-19 Vaccine. https://www.cnn.com/2021/11/02/us/sesame-street-covid-town-hall-questions/index.html

gettr.com

Shit like this is why I don’t let my kids watch TV. They’re much better off watching this, instead.

SML Movie: No Nut November!

You have to go the whole month without a donut!http://www.smlmerch.com

youtu.be

 

[Protistology]

My dad and paternal grandparents now have both shots and one booster as of today. I will report back if they show any symptoms of side effects. I do not have any shots.

Went to visit my elderly mom today and just found out she had the booster yesterday. After her second shot she ended up in the hospital with blood clots in her abdomen (doctors did not suspect the vaccine caused it, but I certainly considered it). She was definitely not feeling well and started having stomach pain today as well as her breathing is a lot more labored (but she has COPD -- this isn't really unusual for her. It's just that lately her breathing had been pretty good and seems to have worsened after the shot.) I'm worried that she's going to end up with clots again. She almost died last time.

Stay away from them and do not share bedding or dishes. They will shed S proteins for about a month.

 

[uncleShitHeel]

I've had discussions with people asking them how it's possible for the vaccines to be working when well over 80% of people in the UK over 80 are "fully vaccinated" and yet, according to the UK government of those 80+ year olds in the hospital because of what the vaccine is supposed to protect you from 88.45% are "fully vaccinated" and their only response is "We're beyond discussing whether the vaccines work, they work and they're safe"

You can't reason someone out of a cult, unfortunately.

I had this conversation the other day and it was mind boggling watching the guy claim one thing, and then contradict himself repeatedly and then un-ironically agree with my deliberately erroneous claims about vaccination rates vs disease in the UK. I'm sure if put verifiable data in front of him he'd probably start screaming about alt-right misinformation and that you can't trust those figures because of behaviours in people or something.

May I add he proudly started the conversation, but loudly bragging about how he unfriended somebody he knew literally down to liking Donald Trump and not wanting to be vaccinated.

I can't believe I live in a world where we are being forced to wear masks, forced to get jabs but still have to wear masks regardless, and all of this coming from a government that has been exposed as having funded the virus, and that virus has a 99.7% survival rate.

Its almost like this is a bunch of bullshit.

Yes, yes it is, and the fact so many people have un-ironically bought the narrative or that so many 'health experts' are pushing for mandates and attempting to forcibly medicate a populace that mostly doesn't need this is genuinely horrifying to me.

By far the most likely explanation is that this is driven by a bunch of panicking incompetents, and grifters who saw a chance to make back multiples of the money they'd thrown away on a failing technology. They don't care that it's killing people.

This.

There is no cabal.

No Illuminati.

Just fucktard politicians and officials who saw an opportunity to make bank and get public asspats, and now that that the medication is clearly not working, they're doubling down on the bullshit in a vain attempt to create plausible deniability when this begins to go tits up and the population turns against them.

I'd care less if I knew none of this would affect me

 

[George Lucas]

The OSHA rule goes into effect in January. Public comment opens in late July.

Wait wtf? We can’t comment until seventh months after it goes into effect?

 

[Drain Todger]

This sounds an awful lot like financial advice, dropping a fat stack on Alnylam tomorrow.

If it works out I'll buy you a hand crafted set of Murmillo equipment.

TBH, I think they're a decent biotech investment for other reasons, too. There are lots of illnesses that are governed by improper gene expression. That said, I recommend digging into them extensively if you're gonna make a commitment.

Therapeutic siRNA: state of the art - Signal Transduction and Targeted Therapy

RNA interference (RNAi) is an ancient biological mechanism used to defend against external invasion. It theoretically can silence any disease-related genes in a sequence-specific manner, making small interfering RNA (siRNA) a promising therapeutic modality. After a two-decade journey from its...

www.nature.com

The challenges for effective Small interfering RNA therapy are basically the same as mRNA therapy or any other small-molecule delivery tech; basically, they would encapsulate them in lipid nanoparticles just like Moderna and Pfizer's COVID-19 vaccines to keep them from being degraded, attacked by the immune system, or cleared by the kidneys. In short, the effectiveness of siRNAs depends on the state of drug delivery tech, much of which is basically bordering on nanotechnology at this point.

In my mind's eye, I'm imagining something like a "biologics machine" in the future where genetic engineers working on-site in hospitals can literally create custom gene therapies and siRNAs and the like from nothing, using a piece of equipment about the size of a soda vending machine with a touchscreen, behind which is a bioreactor and column chromatography purification system that dumps the end-result into LNPs and then spits out a vial of stuff at the end that can be injected into the patient. The only things barring such a machine from existing, aside from the limits of engineering and practicality, are regulations. If each thing vended was its own "drug" that needed to go through testing and certification, the whole concept of tailored gene therapy would be a non-starter. The FDA would have to create leeway and new categories of approval for personalized medicine for this to work out. Everyone's body is just a little tiny bit different, even if there are generalities between all of us.

 

[Escaped Abortion]

https://twitter.com/disclosetv/status/1456386726683873280

One of Biden's aides got the coof. I wonder if it's his personal butt wiper. Hopefully they had lots of close, personal contact with him! You know, gotta test if that quad booster kicked in or not.

 

[Kramer on the phone]

OSHA vax rule just landed

View attachment 2687905

Businesses have until after the holidays to implement Biden Covid vaccine mandate

The newly released Labor Department rules apply to businesses with 100 or more employees.

www.cnbc.com

Biden vaccine mandate: Businesses have until after Christmas to comply

archived 4 Nov 2021 12:52:44 UTC

archive.ph

• Delayed until after the new year, starts Jan 4th
• Employees who aren't vaxed must pay for a weekly covid test starting Jan 4th
• Employees who aren't vaxed must wear a mask at all times starting Dec 5th

Reminder: OSHA probably doens't have the legal authority to do this

And any rule changes like this require public commentary period + 6 months or somesuch to implement

(aka, he's as full of shit as his diapers)

>but.....but....but they don't have the authority to do this!!!!!!!!


-"smart" people in the 1950s when the government forced de-segregation on people.

shout out to those tards waiting for the courts to do something after 2 months of nothing

 

[FatalTater]

Remember the good ol' days when Covid-19 was first making it's official debut and Trump was closing the borders and everyone screeched about how racist he was being?
I wonder if travel was meant to be unrestricted longer and the borders were meant to stay open, but for nefarious reasons.
Actually I don't wonder that much.

 

[helloAhole$]

Wait wtf? We can’t comment until seventh months after it goes into effect?

Well if basing it off of OSHA FAQ this is to be able to address the next pandemic since expected completion date is in June. Reality, they will shift threw a bunch of memes and stupid shit to figure out how to word it better for those who rarely pay attention to not scare them next go around.

Spoiler: A given

Don't want to attempt to start anything here, hell I am sure it will happen without me, but if that website does crash on opening day, (from my understand) my lack of brainwashing, I do want to enjoy at least that fun.

 

[Derka Derka]

Anyone surprised about this one ...

San Francisco Becomes First City in the WORLD To Mandate COVID Injection For Children 5-11 - [your]NEWS

Just a day after the Centers for Disease Control and Prevention (CDC) gave emergency use authorization of the COVID-19 injection to children 5 to 11, the San Francisco government has immediately moved to mandate it for all children in the Bay Area.

yournews.com

 

[YHWH's Strongest Soldier]

I'm possibly late and dumb, but it seems that an uncensored Pfizer contract was leaked by a German MEP. I found the document on this tweet, but I cannot confirm its validity. I have also attached the redacted version for comparison.

https://twitter.com/martinsonneborn/status/1455836782587748352?s=28

Martin Sonneborn on Twitter: "Die Europäischen Grünen (ohne deutsche …

archived 5 Nov 2021 00:04:09 UTC

archive.md

Spoiler: Screenshot of the tweet

 

[Lorne Armstrong]

Anyone surprised about this one ...

San Francisco Becomes First City in the WORLD To Mandate COVID Injection For Children 5-11 - [your]NEWS

Just a day after the Centers for Disease Control and Prevention (CDC) gave emergency use authorization of the COVID-19 injection to children 5 to 11, the San Francisco government has immediately moved to mandate it for all children in the Bay Area.

yournews.com

Not surprised, but very interested to see how it works out for them. I’ve got a sneaking suspicion that even as “Blue” as Frisco is, that there are a lot of parents that aren’t going to want to do this one bit.

Now, whether than means a lot of kids headed to Private Schools or Homeschooling, IDK, but I doubt you’re going to see anywhere close to 100% compliance with that, even in the “Bluest” of the “Blue” cities.

 

[Kramer on the phone]

I have to ask, why would any government do this? I mean yeah I guess it would stop climate change but the majority of the world's population lives in Africa and Asia where it's much harder to get vaccinated. Given the CCP is working hard to make this happen but it still makes for a very inefficient system. Also, how would they be able to keep this quiet and motivate the people working on it to not say "You know it's pretty fucked up to want to indiscriminately kill 50% of the global population to stop climate change and social problems so we can save people's lives." It just doesn't add up to me. I could be wrong though as the Nazi's of course wanted to do something similar. We need to do more research and find a concrete motive for something so random like this and evidence of this motive.

you dont seem to realize how little the types in these jobs actually think about the consequences of their actions, they aren't in it for the money or the job security they just don't care. its a very boomerism way of working "who cares if i'm destroying the lives of my friends and family a mans gotta eat!"

So I have to get the Mark of the Beast to earn money to buy or sell?

I hate the Anti-Christ!

I HATE THIS MEME!!!!!!!

In a couple months you'll start to see lawyers taking wrongful dismissal cases for refusing the Fauci ouchie. I'm going to let them fire me, collect unemployment and then sue when the opportunity comes up.

Just like we'll see lawyers all over the globe take up Kyle and Dereks' cases because they're sure open and shut wins right?

Well if basing it off of OSHA FAQ this is to be able to address the next pandemic since expected completion date is in June. Reality, they will shift threw a bunch of memes and stupid shit to figure out how to word it better for those who rarely pay attention to not scare them next go around.

Spoiler: A given

Don't want to attempt to start anything here, hell I am sure it will happen without me, but if that website does crash on opening day, (from my understand) my lack of brainwashing, I do want to enjoy at least that fun.

that does seem odd, here's another crazy thing! somehow we're supposed to believe the laws of thermodynamics stopped working only in concentration camps for 5 fucking years!!!!!!!

i've been blackpilled since a year and a half ago. These bastards just lost their ass, and decided to triple down. which makes more sense, they got 2 months before they offically lose VA, and 14 months before they lose congress.

Having said that let me remind people UPS has driver jobs opening up for December, to help with the holiday season, relatively good pay for work anyone could do. also shout out to our rich friends who love freedom who aren't doing jack shit about this. Notch is a single old man who will die alone, he could easily be putting up millions to fight this, same with Mr.lucky and the rest. All it takes is people in power willing to say JEWS DESERVE THE HOLOCAUST and their power goes away right?

"If the situation was hopeless their propaganda would be unnecessary is 100% true right?"