Mia Mulder has a video that came out a few months ago where he discusses puberty blockers and how safe they are. Since he isn't a scientist (even Jangles can claim he is one as he has two degrees), he doesn't even try to read the papers he cites. So he has a list of studies that he links on the video
here. I will have to devote time to watch it so I can give a rundown to Farmers here. As he plans to have one on males in women's sport, I will watch that one too.
Anyways, he includes a study on
Brain Maturation on those on puberty blockers.
It is based on one boy, who 'started' a trans identity at the age of nine:
The patient was born at term, of normal weight, displayed a male phenotype, and experienced no intercurrences during pregnancy. The parents confirmed normal neuropsychomotor development for each of the developmental milestones. At age three, they noticed some female behaviors and sought out psychological treatment. They were informed about a possible DG diagnosis, and the child was kept in psychotherapy to “reverse the desire of belonging to the opposite sex” until age seven. The patient and parents report that she made efforts to behave as a boy during this treatment. At nine, she assumed her gender identity and reported believing that she was born the wrong sex, and she wanted to be a girl.
At 11 years and 11 months old, she weighed 35.5 kg, was 145.5 cm in height and was in Tanner stage 2, according to male characteristics. The patient's bone age was compatible with the chronological age for both male and female standards. The biochemical and hormonal laboratory tests were normal for age, born-sex, and Tanner stage (testosterone 182 ng/dl, LH 3.3 and FSH 2.2 IU/L). After written consent of the parents and patient for using GnRHa and for publication of data to scientific article, she started receiving Leuprorelin 3.75 mg IM/every 28 days. In the next months, the GnRHa doses were adjusted according to the clinical signs and hormone levels (last testosterone under GnRHa 29 ng/dl). The affective and social domains improved during the GnRH treatment; however, the teachers and school counselors reported some difficulties, specifically in math and exact sciences.
They casually admit a drop in IQ here, the very measurement these people say is a myth/white supremacist:
The patient's GIQ (global IQ) was further slightly reduced during the follow-up with GnRHa treatment. In fact, the low average GIQ together with impairment in the perceptual organization of intelligence and processing speed index presented even before treatment (T0) suggest that any neurodevelopmental immaturity may have been potentiated by pubertal suppression. Some changes at the functional levels in IQ (e.g., operational memory and EF) can be generally explained by the psychosocial environment or psychopathological status (
Cunha, 2000;
Roughan and Hadwin, 2011;
Zhang et al., 2013;
Cromheeke et al., 2014;
Li et al., 2016). However, the GD girl did not fully meet any criteria for psychiatric comorbidity during the evaluations. Furthermore, she has shown an improvement in her affective and social life due to the prevention of sexual secondary characteristics arousal.
They brush it off as saying these people were already retarded, and also admit this boy has had no sexual arousal or pleasure whatsoever.
Also, it is well known that the brain has different androgen receptor (AR) density, or even lack of AR, along specific areas of white matter and gray matter (
Swinft-Gallant and Monks, 2017;
Wong et al., 2017). In addition, there might be a synchronism between gray matter and WM development during adolescence (
Moura et al., 2017), and these substances might response intrinsically to sex steroids during physiological puberty. In this sense, a plausible explanation for the GIQ decrease should consider a disruption of the synchronic development of brain areas by pubertal suppression. Nevertheless, this is only a speculative discussion about cognition and testosterone. Cognition is more than WISC-IV subtests, and at the present the mechanism for the GIQ decrease observed in this case remains uncertain.
They are straight up admitting puberty blockers reduce IQ, even if it is between the lines. Mulder clearly did not read this study like all troons who reference it. I don't even have a science degree (not yet anyways) and reading things is important.
The conclusion:
Brain white matter fractional anisotropy remained unchanged in a GD girl during pubertal suppression with GnRHa treatment for 28 months, which may be related to reduced serum testosterone levels. The global performance in the Weschler scale was slightly lower during pubertal suppression compared with baseline, predominantly due to the reduction in operational memory. Either a baseline of a low average cognition or the hormonal status could play a role in cognitive performance during pubertal suppression. The variation in voice frequency was consistent with the testosterone levels and peripheral testosterone effects, as seen in vocal folds. Further longitudinal clinical studies comparing DTI parameters and cognition among TG adolescents under puberty suppression and age-matched controls with physiological pubertal development are needed in order to confirm the present findings and support the hypothesis on the impact of sex hormones on cognition and brain maturity during developmental stages.
This one was a survey asking troons if people ever tried to tell them they were actually men/women. Discusses 'conversion therapy' and how telling a troon he will never be a woman is deadly to them.
This one is measuring MRI scans and IQ between untreated troons, troons on PBs, and normal kids. In the meat of the study it says this:
Accuracy significantly differed between the groups (F(5, 79) = 3.07, p < .05). Post hoc analyses showed that the suppressed MFs had significantly lower accuracy scores than the control groups (p = .02 compared to control boys and p = .04 compared to control girls) and the untreated FMs (p = .04). IQ and accuracy were significantly correlated (r = 0.31, n = 85, p < .005), but even after correcting for IQ, a significant effect of group on accuracy remained (F(5, 7

= 2.70, p < .05). Additionally, there was a significant negative correlation between IQ and RT (rs(85) = −0.31, p < .005). However, RT did not significantly differ between the six groups (H(5) = 3.92, NS). No significant correlations between age and the performance scores were found. Means and standard deviations of accuracy and RT are presented in Table 1. For the baseline condition (counting the blue and yellow balls) no significant group differences were found for accuracy (F(5, 79) = 0.28, NS) or RT (F(5, 79) = 1.16, NS).
ROI analysis did reveal sex differences in brain activations associated with ToL performance. Control boys showed significantly greater activation in the bilateral precuneus and right DLPFC (trend) during high task load compared to control girls. In a previous study (Boghi et al., 2006) adults showed similar sex differences in the precuneus, whereas the sex difference in DLPFC activation was reversed; women exhibited greater DLPFC activation than men. A possible explanation for this discrepancy is that the DLPFC is not yet fully developed in our participants. In a Go-No-Go study children displayed greater activation of the DLPFC than adults, this was explained as resulting from greater network efficiency in adults (Casey et al., 1997). Since frontal gray matter starts developing earlier in girls than in boys (Giedd, 200

network fine-tuning may start earlier as well. During adolescence the DLPFC may still be under the influence of pubertal hormonal effects, either activational or organizational (Romeo, 2003; Sisk and Zehr, 2005) whereas this is no longer the case for the precuneus, since a strong bilateral sex difference is present both in adolescents (present study) and adults (Boghi et al., 2006).
In the discussion it openly says they do not have 'ladybrains' or 'male brains' and that their brain activity does indeed match the natal sex of their control groups. They are 'inbetween', or 'atypical'. So it's obvious Mulder did not even read the goddamn studies he references. Hoo boy his Troons in Women's sport is going to be a hoot. No doubt he's going to 'debunk' Queen TERF Emma Hilton and her paper.
The other paper is on bone mineral density; I may have referenced it when discussing something else.
Remember guys, no one under 16 is being put on puberty blockers:
In GD, GnRHa can be used from the early / middle stages of puberty with the aim of delaying irreversible and unwanted pubertal body changes and giving young people the opportunity to explore their gender identity during a period when puberty is not advancing.[
3] This period also allows clinicians more time to assess the stability of young people’s gender identity.[
6] Despite this treatment being given in mid-puberty it is also called early puberty suppression, where ‘early’ refers to earlier than the historic practice of suppression after completion of puberty.
Pubertal suppression is currently practised in the majority of international centres across Europe, the Americas and Australasia, as evidenced by a recently published survey of 25 international centres by the European Society of Paediatric Endocrinology (ESPE).[
12] Pubertal suppression with GnRHa as monotherapy is a time-limited strategy, due to the potential for side effects with long-term use. In the UK, for those commencing under age 15 years, use of GnRHa alone ceases after 16 years when young people face a decision to return to the sex hormones produced by their body or begin cross-sex hormones.[
5] There are limited data on the outcomes of pubertal suppression in the treatment of young people with GD.[
3,
13] A recent systematic review included data on the physical and mental health outcomes of pubertal suppression using GnRHa in over 500 young people.[
4] Longer-term follow-up data on pubertal suppression in GD are limited to individuals from four cohorts.[
14-
19]
NO ONE UNDER 16 IS GOING ON HORMONES, BIGOT
Baseline characteristics of the participants by birth-registered sex are shown in
Table 1.
Median age at consent was 13.6 years (IQR 12.8 to 14.6, range 12.0 to 15.3). A total of 25 (57%) were birth-registered as male and 19 (43%) as female. At study entry, birth-registered males were predominantly in stage 3 puberty (68%) whilst birth-registered females were predominantly in stages 4 (58%) or 5 (32%) with 79% (15/19) post-menarcheal. 89% of participants were of white ethnicity. Birth-registered females were on average 6 months older than birth-registered males at study entry.
Median age at the end of the GnRHa pathway was 16.1 years (
Table 1). A quarter of participants made their decision more than six months later, either because they wished to delay due to school exams or other events or because clinicians felt they were not yet ready to make the decision. One young person decided to stop GnRHa and not start cross-sex hormones, due to continued uncertainty and some concerns about side-effects of cross-sex hormones.
The remaining 43 (98%) elected to start cross-sex hormones.
In their own abstract they said this didn't happen
BMD was available on 44 participants at baseline, 43 at 12 months, 24 at 24 months and 12 at 36 months (
Table 3). Numbers were lower for hip than for spine as some hip scans were not done for technical reasons. The table shows mean values at baseline and 12, 24 and 36 months, along with mean baseline values corresponding to the paired samples at each time point. There was no change from baseline in spine or hip at 12 months nor in hip at 24 and 36 months, but at 24 months lumbar spine BMC and BMD were higher than at baseline, as was lumbar BMC at 36 months. Lumbar and hip BMD age-adjusted z-scores were in the normal range at baseline but point-estimates fell at 12 and 24 months but not at 36 months. Point-estimates for height-adjusted z-scores for lumbar and hip BMD also fell at 12 and 24 months but not at 36 months.
Did the kids stop self-harming? No, not really:
The first psychological follow-up was at a median of 13 (IQR 12, 14) months after start of treatment, with ASEBA data available for 41 participants (parent and self-report). ASEBA data at 24 months (median 25 (21, 2

) were available on 20 young people by parent report and 15 by self-report, and at 36 months (median 36 (29, 39)) on 11 by parent report and 6 by self-report.
Formal testing was undertaken only for key ASEBA outcomes (
Table 4). For the CBCL total t-scores, there was no change from baseline to 12, 24 or 36 months. Similarly for the YSR total t-score, there was no change from baseline to 12 or 24 months; YSR data at 36 months (n = 6) were not analysed. There were no significant changes in parent-report CBCL self-harm index scores from baseline to 12, 24 or 36 months, nor for self-report YSR self-harm index scores.
Here's the kicker. The abstract said there were no changes in BMD, but they admit right here the growth in girls and boys were stunted:
As anticipated, pubertal suppression reduced growth that was dependent on puberty hormones, i.e. height and BMD. Height growth continued for those not yet at final height, but more slowly than for their peers so height z-score fell. Similarly for bone strength, BMD and BMC increased in the lumbar spine indicating greater bone strength, but more slowly than in peers so BMD z-score fell. These anticipated changes had been discussed with all participants before recruitment to the study. Young people experienced little change in mean weight or BMI z-score in the first two years. The rise in weight and BMI z-score at 36 months may represent a trend towards greater adiposity in those on GnRHa for a prolonged period, or reflect a higher baseline in this group.
They also admit they they MUST go on cross sex hormones to stop the density loss:
Our findings that BMD increased over time in the lumbar spine but more slowly than in same age peers, resulting in a fall in z-score, are similar to others.[
4,
14,
39,
40] The fall in height-adjusted BMD z-score was consistent with but larger than the fall in height z-score. We found that birth-registered sex and pubertal status at baseline were not associated with later BMD. There is evidence that accretion of bone mass resumes and that BMD increases with the start of cross-sex hormone therapy,[
4,
14,
39,
41]. Future research needs to examine longer-term change in BMD in young people treated with mid-pubertal suppression.
No decrease in psychological distress:
We found no evidence of change in psychological function with GnRHa treatment as indicated by parent report (CBCL) or self-report (YSR) of overall problems, internalising or externalising problems or self-harm. This is in contrast to the Dutch study which reported improved psychological function across total problems, externalising and internalising scores for both CBCL and YSR and small improvements in CGAS.[
24] It also contrasts with a previous study from the UK GIDS of change in psychological function with GnRHa treatment in 101 older adolescents with GD (beginning > 15.5 years) which reported moderate improvements in CGAS score over 12 months of GnRHa treatment.[
49] CGAS scores in this previous study increased from 61 to 67 with GnRHa treatment, similar to those (63 at baseline, 66 at 24 months) in our study. Follow-up of the Kuper et al. cohort found non-significant changes in depression and anxiety scores in those (n=25) who had only pubertal suppression treatment, although improvements were seen in the whole sample combining these with those receiving cross-sex hormones.[
17] A second US cohort reported that in 23 young people who had received pubertal suppression (using GnRHa or anti-androgens in birth-registered males and either GnRHa or medroxyprogesterone in birth-registered females), there was a reduction in depression scores in birth-registered males but not females.
The whole thing is a bunch of redpills hidden in blue pills, and once again it's obvious Mia Mulder did not read the studies he cites. Fucking hell, troons as just as bad as DebateBros. They just read the abstract and assume it is in their favour. READ THE DAMN THING FIRST.
Study abstracts often conflict with study results, as el gato malo said. And this is true. You need to read the meat of the study before saying it agrees with you. Haven't seen this much of a fail since Jangles.
CopsHateMoe also released a video on 'Transmedicalism', and I plan to watch that one too. She also referenced Two Spirit and didn't read the source that said the term was invented in the 90s. This broke ass white girl needs to seriously read more, but then again, she threw a bitch fit over 'adult human female' posters.
Edit: forgot one. Mulder referenced
this consensus study. He forgot the part where it says this:
Puberty suppression has become an increasingly available option for transgender youth, and its benefits have been noted, particularly in the area of mental health. However, puberty is a major developmental process and the full consequences (both beneficial and adverse) of suppressing endogenous puberty are not yet understood. The experts who participated in this procedure believe the effects of pubertal suppression warrant further study, and this Delphi consensus process develops a framework from which future research endeavors can be built.
"We just don't know, let's sterilize the kids anyway and let 'em figure it out!"