Wuhan Coronavirus / COVID-19 Thread 2: Booster Shot - Resume all Corona sperging here.

Quick summary of 2 articles (1,2) concerning a recent deboonking stoody of ivermectin.
Clinical trial used a protocol where :
-the dosage was lower (400µg/kg < 600µg/kg) than recommended by FLCCC (Frontline COVID-19 Critical Care Alliance)
-patients were told to take the drug on an empty stomach, which seems to decrease bio-availability (absorption).
-3 days course of treatment instead of the 5 days recommended by the FLCCC
-placebo group poorly followed to ensure compliance with the protocol
-recorded and added all events, ranging from simple ER visit without stay to full hospitalization, to compare test and placebo
Ivermectin group had a slightly reduced occurrence of events, but not in a statistically significant way.
DEBOOOOOONKED. WSJ and NYT both ran stories based on this trial.
The bad faith, if not outright sabotage, is astounding. All the parameters were chosen in a way that minimizes the chances of finding a positive result. It's like proving that you can't win a race by intentionally dragging your feet. Very common junk science strategy unfortunately, same stuff they do to avoid finding a link between <thing> and <disease>.

Second article is talks about academia shenanigans circa January 2021.
A doctor (Andrew Hill) that was part of a group effort to support to promote ivermectin turned coat at a few days before publication.
He released a much less optimistic review of the evidence for ivermectin instead.
Boomers gonna boom, the pdf he released was digitally signed with the name Andrew Owen in the metadata.
Andrew Owen is a professor at the Uni of Liverpool, who had just received a $40 million grant a few days prior.
The grant is awarded by UNITAID (funded by Gates and a bunch of Govs) for a joint venture by UNITAID, Uni Liverpool and private pharma in which Owen is a shareholder.
This paper was instrumental in informing the WHO regarding ivermectin.

Note : I fucking hate this type of grifter website with their Kennedy book shilling and 20mn long videos adding sad music for drama. The info is good and valuable and they muddy everything with this shit. The substack of the guy who uncovered the pdf metadata is also paywalled. I understand those people spend a lot of time on this and need to get paid but all that stuff is in every "conspiracy theory red flags to watch out for" put out by legacy media. All this really undermines the dissemination of information and its optics.
 
Quick summary of 2 articles (1,2) concerning a recent deboonking stoody of ivermectin.
Clinical trial used a protocol where :
-the dosage was lower (400µg/kg < 600µg/kg) than recommended by FLCCC (Frontline COVID-19 Critical Care Alliance)
-patients were told to take the drug on an empty stomach, which seems to decrease bio-availability (absorption).
-3 days course of treatment instead of the 5 days recommended by the FLCCC
-placebo group poorly followed to ensure compliance with the protocol
-recorded and added all events, ranging from simple ER visit without stay to full hospitalization, to compare test and placebo
Ivermectin group had a slightly reduced occurrence of events, but not in a statistically significant way.
DEBOOOOOONKED. WSJ and NYT both ran stories based on this trial.
The bad faith, if not outright sabotage, is astounding. All the parameters were chosen in a way that minimizes the chances of finding a positive result. It's like proving that you can't win a race by intentionally dragging your feet. Very common junk science strategy unfortunately, same stuff they do to avoid finding a link between <thing> and <disease>.
I read that study.


The mean (±SD) number of days with Covid-19 symptoms before randomization was 3.8±1.9.

Compare that with the known clinical course of COVID-19:

viruses-13-00963-g001 (6).png

By day 4, the viral load is already on a down-slope and the benefit from antivirals has almost completely evaporated.
 
Okay, I thought this was ridiculous before. Now, it's really getting ridiculous.


Pulled a copy of Burke's September 8, 2020 affidavit referenced in your video and attached. Other court docs can be found HERE and at the USSC's docket page for Republican Party of Pennsylvania, Applicant v. Kathy Boockvar, Secretary of Pennsylvania, et al.

Skimmed it real quick (it's 95 pages), here's 2 highlights that sum up the basic thrust of it.

1. Corona-chan stalks voting booths like rapehons stalk womens' bathrooms.

This study found that counties with higher than average in-person voting had twice the rate of COVID-19 po sitive tests in the weeks that followed the election. Across a range of exploratory models, the team found a large post-election increase in COVID- 19 cases in counties that had more in-person votes per voting location, all else being equal. They also noted a decrease in the number of new positive COVID-19 cases in countieswith relatively more mail-in absentee votes after accounting for differences in in-person voting, county-level COVID-19 testing, and population measures. 62 This study was a thorough attempt to determine the relationship between the amount of in-person voting per polling station and subsequent COVID-19 diagnoses in the relevant counties.

2. Mail-in vote or die, bitch!

90. Based on my decades of professional experience in medicine, epidemiology, and public health, it is my assessment that the health risks of in-person voting in the midst of an inf ectious disease pandemic are clear and significant. In-person voting on elec tion day will undoubtedly increase the chances for exposure to the novel corona virus for poll workers and voters alike, leading to more cases of SARS-CoV-2 infection. Reducing in-person voting on election day will reduce the spread of SARS-CoV-2 and reduce illness and deaths from the resulting COVID-19.
 

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I know who's that SOB is and I hope karma will bite him back.

Btw, some good news and I hope it's not an April Fools' day joke on us.
I actually think that may be an older article. These published a few days ago look like the injunction has been expanded to the entire navy. It sounds like it partially may be due to the fact that the navy appeared to have a policy of never accepting religious exemptions, so this may not work out the same for other branches of the military.
Here's the document they seem to be referring to
 
So here's the latest vaccine surveillance data from the UK

1648827822686.png


For all age groups under 50 there is now NO difference in mortality rates between the boosted and the unvaccinated. There is however a massively increased risk of becoming infected. The holy boosted are 3-4 times more likely to become infected with Covid.

The obvious fact that the vaccines have done nothing but fuck up people's natural immune response to infection is becoming harder and harder to cover up.

So congratulations to the vaxxed. If you are an old deathfat you have a slightly decreased risk of dying (not becoming hospitalised) at the price of not receiving broad natural immunity when you catch the bug, and you will catch the bug.

Vaccine efficacy can only be judged over the lifetime of the jabbed. By any metric they're a horrendous failure, the debate is over.

And this is why

1648828452139.png



The unvaxxed are a reducing target for the virus. If you managed to avoid getting jabbed and you have since contracted and recovered any risk from the virus is done. At worse you may get a mild cold in a few years.

For the jabbed you can look forward to a lifetime of catching recurrent shitty flus which may one day kill you if you get a bad enough dose.

Yes this is the price for being a retarded nigger cattle. And yes you totally deserve it.
 
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You may not like it but this is what peak vaccine efficacy looks like.
It really is the most amazingly awful vaccine of all time. I'm still shocked at just how dumb people are to have been conditioned into accepting it was never meant to prevent transmission or infection when there would be no way of it breaking the pandemic in that case. If the measles or mumps vaccines had worked that way we would have seen people going to school covered in spots and saying they are fine.

That never happened. It just point blank never happened. Previous vaccines at least had a noticeable effect on breaking out in recognizable illness. It's not like you get a bit of rabies with the rabies vaccine. Break through cases in that circumstance were actually rare. If ones were occurring that didn't show symptoms, we would not have recognized them as a true infection back then, which is the dumbest change in our understanding of disease that covid has brought about, but there are tons of fully symptomatic "breakthrough" infections so that's still moot. The jab is shit at doing what it set out to do. It does not break the transmission cycle and hopefully it's actually so useless that it doesn't even challenge covid in the body at all and that's all that's saved us from having it drive up the virulence of covid as was seen in Merek's disease.

At least the flu shots are all for different species of virus that we just put under the banner of flu. They actually work a bit if the science guessed the right strain in the lottery that year, the problem being it changes so much and there are thousands of species so they are more likely to be wrong than not. It's a bit like winning the Numbers Game lottery, but if H1Whatever was the strain that year and you were old, maybe it would have some marginal benefit due to cross immunity. It's also a pretty stupid thing to vaccinate against, but if you are a hypochondriac and want it, you do you.

My covidian friends are also super excited that Moderna is going to make a shot against even the basic ass cold now. You know what? I'm going to embrace colds. I think it's like weightlifting. Sometimes I want my body to use its functionality in a relatively safe environment. I don't even think I want a cancer shot at this point. I'm just ready to embrace mortality and face whatever time I get. It's better than the alternative of hopping up on constant treatments to try and deny biology.
 
Aren't you fat? Like morbidly obese level? Why would I listen to someone on health when they can't even take care of themselves?


Yes, he really is a massive fat cunt. He's a PofI, he has a thread and his Twatter account is linked on there. He's a fucking eatbeast and instead of stopping pigging and binging and gorging, and because he lives at home, rent-free, with his retard enabler parents, he's fucking ballooned the last couple of years.

Funny how these cunts are all about butbutbutmuhmuhmuh coveeedddsssss, but won't stop fucking eating to lose weight, when the proof of covid smiting fat cunts harder, longer and being more deadly has been consistently proven since the off.

Edited to say, his Twatter is a riot. He's your typical identikit "I'm such a soopah doopah totes srs bsns l33t n3rd". MLP, Funko Pops, Star Wars, Wrestlemania, Cartoon Network and a worrying fixation on fan artwork of very, very young looking characters. Clearly Grant McLelland has a thing for the jailbait, and assuming his prick isn't buried under mounds of fat, I'd put money on him beating off to pictures of young looking girls.

He also obsessively re-tweets stuff from some blue tickmark fluffhead, Tara Strong" (nope, no clue) and that's pretty pathetic. Granty boy, she's never going to notice you, much less marry or fuck you pal. Quit already. Go on, fatbopy pedo, screencap this to your fucking social media account, you porky, wannabe kiddie fucker.

Oh, and he's one of these cunts who likes to screencap from the Farms onto his Twatter feed. Funny bit is though, nobody interacts with him, retweets him, barely any likes, no comments. Honestly Grant, delete the account, nobody acknowledges your existence on there anyhow,, get outside and touch some fucking grass. Maybe do something to get a better nob, so you can move out. Whatever, but stop deluding yourself about what you are - a fat, retarded little boy, whose body is fucked due to gluttony, who has basically no fucking personality beyond whatever puerile, childish hobbies you've got. A rabid cons00mer of crap, tat and meaningless plastic fucking junk. A little boy who does not make or create anything, but who instead sits and cons00000mmms like a passive fucking glob. A person with at best questionable tastes in some things, with a worrying fixation on artwork of young looking girls, and who is clearly obsessed with some blue checkmark twatter gobshite who doesn't know you exist.

In short, Grant, you are an example of the pestilence and cancer of social media fucking destroying brains, minds, and lives. You could sort your shit out. You could get a hobby, learn a skill, learn to make something, volunteer, whatever. But instead, you just take and cons00m and buy and eat.


What a fucking empty, hollow existence. People who're in wheelchairs with locked in syndrome, people with months to live, people in crippling agony, have better lives than you do.

Further edit:He wasn't always a fucking fat ass. Though fuck me sideways, he's one bizarre looking fucking goblin.
 
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@Lichen Bark @SCSI @borsabil
Oh. My. God. :stress:

1648843005190.png


We found that the Pfizer/BioNT vaccine down regulate the concentration of cytochrome c in mitochondria upon incubation with normal and tumorous glial cells. Concentration of oxidized form of cytochrome c in brain cells has been shown to decrease upon incubation the mRNA vaccine. Lower concentration of oxidized cytochrome c results in lower effectiveness of oxidative phosphorylation (respiration), reduced apoptosis and lessened ATP production. Alteration of Amide I concentration, which may reflect the decrease of mRNA adenine nucleotide translocator. Moreover, mRNA vaccine leads to alterations in biochemical composition of lipids that suggest the increasing role of signaling. mRNA vaccine produce statistically significant changes in cell nucleus due to histone alterations. The results obtained for mitochondria, lipid droplets, cytoplasm may suggest that COVID-19 mRNA (Pfizer/BioNT) vaccine reprograms immune responses. The observed alterations in biochemical profiles upon incubation with COVID-19 mRNA in the specific organelles of the glial cells are similar to those we observe for brain cancer vs grade of aggressiveness.


According to a VigiBase report from WHO, instances of auditory loss also referred to as tinnitus was observed in people who were given COVID-19 vaccinations, primarily those that took the shots of Pfizer-BioNTech.


There have been reports of SSHL following immunization with Pfizer and Moderna COVID-19 vaccine; however, no etiologic relationship has been established between the two entities yet.
 
Just found out I'm not going to be able to work at my usual summer camp this year because of vax mandates. I was there all last year and no one on campus including kids and staff had a single case of COVID due to an aggressive testing regime and quarantining, so i'm not sure what they think changed this year that necessitates a mandate.
Not only do they want you vax-maxed they want TWO boosters w/ proof no less than 2 weeks before you attend camp. I hate to do it but I'm noping out of this one. I think there's going to be a ton of people feeling like shit for the first week of camp and possibly some hospitalizations or health scares. Insanity man.
 
@Lichen Bark @SCSI @borsabil
Oh. My. God. :stress:

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I mean vaxxed niggercattle don't listen to facts and common sense NOW, what would the difference be?
 
@Lichen Bark @SCSI @borsabil
Oh. My. God. :stress:

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What about that part about pseudouridine causing cytochrome c inhibition??????????
uh oh 1.PNG

https://www.cell.com/cell/fulltext/...m/retrieve/pii/S0092867400800859?showall=true
https://archive.vn/LGfqq
uh oh 2.PNG
Is that good?

This hearing stuff is spooky, it's odd, I know someone who just recently started having concerns about their hearing (pfizer vaxxed, probably boosted), they aren't old. Also news of a case of terminal stage 4 cancer also makes me wonder a bit, especially since this person wasn't overweight at all. They were old, but I considered them one of those "old people who are healthy, and I'd like to emulate in my old age." Maybe it was a case of "they were afraid to go to the doctors" but I do wonder.

The MT-RNR1 fragments affecting the "regulation of the folate cycle." What's a folate cycle anyway?
uh oh 3.PNG

Key metabolic processes, oh.......
:semperfidelis:
I'm sure it'll be fine......
 
I actually think that may be an older article. These published a few days ago look like the injunction has been expanded to the entire navy. It sounds like it partially may be due to the fact that the navy appeared to have a policy of never accepting religious exemptions, so this may not work out the same for other branches of the military.
Here's the document they seem to be referring to

Oh nice, that Navy Seals case finally moved (and thank you for linking the court opinion, saved me the hassle of chasing it down). Looks like the Q1 court lull is finally ending, I'll have to start up my CoVax legal news roundups again. Anyway, let's see what's up with this.

Net Result:

So the combined effect of the March 28th order from the district court judge, and the March 25th decision from the Supreme Court, is a win some, lose some compromise. All Navy personnel are now protected by the injunction from being punished or fired, but they are not shielded from having their day to day duties changed, based on their vaccination status -- so long as said change isn't motivated by an intent to punish the employee because they're unvaccinated. Basically, the Navy can stick you behind a desk doing unimportant work, if they say it's because that way, if your dirty unvaxxed self gets sick, you won't fuck up group effectiveness. (Good luck furthering your career if you never get to do anything other than sweep decks and count the bolts on the ship, especially if you originally trained to be a SEAL.)

"But Y Tho":

Traditional deference from the Courts with regards to how the military handles matters of defense (legal funfact -- this was the same reasoning they used in the infamous Japanese internment camp case, Korematsu). From Kavanaugh's 6-3 majority opinion from March 25th (13 pages for majority and dissent combined, attached):

I concur in the Court’s decision to grant the Government’s application for a partial stay of the District Court’s preliminary injunction for a simple overarching reason: Under Article II of the Constitution, the President of the United States, not any federal judge, is the Commander in Chief of the Armed Forces. In light of that bedrock constitutional
principle, “courts traditionally have been reluctant to intrude upon the authority of the Executive in military and national security affairs.”

Court says they shouldn't backseat driver something this far outside their area of expertise, plus the Navy has an "extraordinarily compelling" interest in being able to run their own shit without meddling from non-military normies.

In this case, the District Court, while no doubt well-in-tentioned, in effect inserted itself into the Navy’s chain of command, overriding military commanders’ professional
military judgments
. The Court relied on the Religious Free-dom Restoration Act. See 42 U. S. C. §2000bb −1(b). But even accepting that RFRA app lies in this particular mili-
tary context, RFRA does not justify judicial intrusion into military affairs in this case. That is because the Navy has an extraordinarily compelling interest in maintaining stra-
tegic and operational control over the assignment and de-ployment of all Special Warfare personnel—including con-trol over decisions about military readiness
. And no less
restrictive means would satisfy that interest in this context.

Dirty unvaxxed in the field could threaten readiness.

The Court “should indulge the widest latitude” to sustain the President’s “function to command the instruments of national force, at least when turned against the outside
world for the security of our society.” Youngstown Sheet & Tube Co. v. Sawyer, 343 U. S. 579, 645 (1952) (Jackson, J., concurring). That fundamental principle applies here. As
Admiral William Lescher, Vice Chief of Naval Operations, explained: “Sending ships into combat without maximizing the crew’s odds of success, such as would be the case with ship deficiencies in ordnance, radar, working weapons or the means to reliably accomplish the mission, is dereliction of duty. The same applies to ordering unvaccinated person-nel into an environment in which they endanger their lives, the lives of others and compromise accomplishment of es-sential missions.”

Moving over to the district court opinion from 3/28 (27 total pages, attached), we can see it has a fun start -- "we're doing a thing, but immediately putting it on hold under certain circumstances." At least class certification is now official. Note that this is all limited only to those Navy nerds who are specifically applying for religious exemptions, not other types.

Having considered the briefing, the Court concludes that Plaintiffs’ Motion for Class Certification should be and is hereby GRANTED in part. The Court also GRANTS Plaintiffs’
Motion for Class-Wide Preliminary Injunction, but immediately STAYS the injunction “insofar as it precludes the Navy from considering respondents’ vaccination status in making deployment, assignment, and other operational decisions.”

Skipping over all the class certification stuff because it's boring as hell and largely a "no duh" thing -- Navy employees all face the same problem from the same source, and getting reprimanded or dishonorably discharged is the same harm whether one's a cook or a SEAL. Moving on to the more interesting bit -- the district court judge went the opposite way Kavanaugh did on the "deference to military command in military matters" doctrine. First point is that the Navy is rubber stamping every single one of these religious exemption requests "DENIED", and is being so egregious about it that the opportunity to get some kind of relief without resorting to the courts amounts to a lie.

Each of the Named Plaintiffs and the class members have, by definition, submitted religious accommodation requests. According to the latest numbers in the briefing,n the Navy has denied 3,728 of these 4,095 requests. It has granted none. Defendants say the Court must wait for the Navy to decide each request, because otherwise, “one can only speculate as to the final outcome of any proceedings.” Id. at 12 (quoting Smith v. Harvey, 541 F. Supp. 2d 8, 13 (D.D.C. 2008)).
The record indicates the denial of each request is predetermined. This is even more evident today than it was at the time of the Court’s January 3 Order, when the Navy had made no final determinations on appeal. See Order 4, ECF No. 66. Now, the Navy has finally adjudicated at least eighty-one appeals by denying each of them. Even though the Navy has adjudicated thousands of requests, it has not granted a single one. These class members need not wait for the Navy to engage in even more empty formalities. Because exhaustion is futile and will not provide complete relief, the case is justiciable.

Court moves on to the four-prong test.

The Court then weighs four factors to determine whether the issue is justiciable: (1) the nature and strength of the plaintiffs’ challenge; (2) the potential injury to the plaintiffs if review is refused; (3) the type and degree of anticipated interference with the military function; and (4) the extent to which the exercise of military expertise or discretion is involved. Id. at 201–02. Each of these factors suggest that the class’s claims are justiciable.

Skipping 1 and 2 because it's something that's come up in every other religious exemption case I've sperged about on here before. Moving on to 3 and 4 because the military context is new.

Point 3 denies that the mere fact that there will be some interference is fatal. But the Court acknowledges that this isn't a blank check, and limits their order to allow the Navy to still take vaccination status into account for what duties to give someone, staying consistent with the USSC.

Third, the type and degree of anticipated interference with the military function weighs in favor of judicial review. “Interference per se is insufficient since there will always be some interference when review is granted.” Mindes, 453 F.2d at 201. Whether denying religious accommodations violates the First Amendment is a distinct legal question that would not “seriously impede the military in the performance of vital duties.” Id. Insofar as an injunction “precludes the Navy from considering respondents’ vaccination status in making deployment, assignment, and other operational decisions,” this Court will partially stay the order.

As for point 4, the Court pushes back on the "Courts are incompetent in military matters" with a reminder that it goes the other way, too, and military brass are incompetent in legal matters, which violations of 1st Amendment religious rights are -- and therefore, departing from the default deference is the right move.

Fourth, the extent to which the exercise of military expertise or discretion is involved weighs in favor of review. “Courts should defer to the superior knowledge and experience of professionals in matters such as promotions or orders directly related to specific military functions.” Mindes, 453 F.2d at 201–02. Of course, “judges don’t make good generals,” but “it’s a two-way street: Generals don’t make good judges—especially when it comes to nuanced constitutional issues.”

The rest of the opinion is similar to non-military cases that have succeeded in the past -- the Navy shows a clear pattern of treating religiously-based exemption claims differently from secular-based ones, its using a non-individualized sledgehammer policy to deny claims in a context that requires individualized examination of claims to avoid unlawful infringement on a key Constitutional right, which shows an impermissible underlying motivation of hostility to religion, and this one-size-fits all approach, combined with how overwhelmingly successful they've been in getting their staff vaccinated without extreme measures (99.4% of the Navy is vaccinated or has a valid medical exemption), shows that this is not the least restrictive means available in accomplishing their goals of maximizing readiness. Or, in fewer words -- don't be lazy euphoric neckbeards, sit down and talk to your religious objectors and work this shit out like adults.




So this is more evidence backing up the earlier studies that seemed to point to a risk of spontaneous necrosis, as well as cancer, when cells get confronted with tranny mRNA. Delightful.

@Lichen Bark @SCSI @borsabil
Oh. My. God. :stress:
<snip>


Deafness? That's a new one. Wonder if that one turns up in any of the FOIA docs yet. Also, interesting it's so far specifically associated with Pfizer, when so many of the other side effects seemed to hit Moderna worse, since they appeared to be influenced by the dose size, and Moderna was megadosing.
 

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It does not break the transmission cycle and hopefully it's actually so useless that it doesn't even challenge covid in the body at all and that's all that's saved us from having it drive up the virulence of covid as was seen in Merek's disease.
The Omicron variant supposedly was manufactured in a laboratory to prevent a scenario like that, or another scenario such as vaxxoids dropping like flies when exposed to the disease. Maybe it was even supposed to be the vaccine because the powers that be wanted the scamdemic to wind down and the actual "vaccines" were utter garbage. How true that is I have no clue, but the timing and place of its emergence is suspicious, especially how South Africa totally downplayed it compared to other new variants which received the "totes deadly 4 realz dis tyme!" treatment universally. Unlike the original Wuhan virus, I don't believe there's much in the way of a paper trail for just who created the virus, only some evidence that the Omicron variant did not evolve naturally.
 
The Omicron variant supposedly was manufactured in a laboratory to prevent a scenario like that, or another scenario such as vaxxoids dropping like flies when exposed to the disease. Maybe it was even supposed to be the vaccine because the powers that be wanted the scamdemic to wind down and the actual "vaccines" were utter garbage. How true that is I have no clue, but the timing and place of its emergence is suspicious, especially how South Africa totally downplayed it compared to other new variants which received the "totes deadly 4 realz dis tyme!" treatment universally. Unlike the original Wuhan virus, I don't believe there's much in the way of a paper trail for just who created the virus, only some evidence that the Omicron variant did not evolve naturally.
 
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I mean vaxxed niggercattle don't listen to facts and common sense NOW, what would the difference be?
Some jackass I know on Discord had this to say:

Yeah, but for the lot of us here, the pandemic is pretty much this:
'Are we all going to die? Yes/No.'
'What are the government's requirements this month about it?'
Beyond this, the stats, variant names, etc., do not change anything for the lot of us.

Pretty much everyone here outside [Drain Todger] is in this situation.

Also him, a month earlier:

Ukraine is going to be Europe's Israel in terms of memetic badass army.

1646009879277.jpg

@SCSI
So this is more evidence backing up the earlier studies that seemed to point to a risk of spontaneous necrosis, as well as cancer, when cells get confronted with tranny mRNA. Delightful.

For those in the back, this is a QRD on how molecular cell biology works:

Cutaway-drawing-cell.jpgAnimal-Cell-Animal-Cell-Diagram-Animal-Cell-labelled-Animal-Cell-Function-Animal-Cell-structur...png

A typical eukaryotic animal cell (tens of trillions of which make up the human body) looks a little something like this. The nucleus holds DNA and is the site of gene expression. DNA is the long-term storage form of a gene, which encodes a template for a protein. When cells divide, they make copies of their chromosomes (so the new cell has the same genes and can manufacture all the same proteins). The way a cell makes proteins is by reeling out a certain region of its DNA inside its nucleus, copying it to RNA by using RNA polymerase molecules that link the bases together end-to-end, and then, releasing this mRNA. The mRNA leaves through a pore in the nucleus and transits the endoplasmic reticulum, where it encounters ribosomes that lock onto it and link amino acids together into a polypeptide chain which folds in on itself to become a protein. This protein then experiences further processing in the Golgi apparatus, before it is either exported from the cell or becomes part of the cell's internal contents or its plasma membrane as a membrane-bound protein. The lysosome is a recycling center that breaks junk back down into raw materials. The mitochondria produce energy for the cell via the electron transport chain and their proton gradient, synthesizing adenosine triphosphate. The whole reason why humans (and other animals) breathe oxygen is for it to act as a final electron acceptor in the electron transport chain. Mitochondria are the site of respiratory metabolism inside cells. They also have their own genome, and are almost something like a little symbiote inside our cells.

To visualize the electron transport chain, think of a stone perched at the top of a hill and how it has potential energy due to gravity, or water in a reservoir flowing through power turbines in a dam. Electrons also flow "downhill" in mitochondria, so to speak, jumping from molecule to molecule.




Mitochondria are not merely "the powerhouse of the cell". They are also sites of all sorts of oxidation reactions and cell survival pathways. They help regulate programmed cell death.


Cytochrome C is essential to both the electron transport chain and to programmed cell death. Mitochondrial membrane permeabilization and cytochrome C being released into the cytoplasm of a cell is one of the ways a cell tells itself "oops, I'm dead". Cells can't survive without mitochondrial function, and cytochrome C outside the mitochondria is basically an indicator that the mitochondria are being busted open like little pinatas. Oxidative stress/overaccumulation of ROS in a cell is one way that mitochondria can end up completely fucked.

Inhibition of components of the electron transport chain would lead to mitochondrial dysfunction, reduced ATP synthesis, and reduced energy for the cell. That's one way mitochondrial deafness could happen. If auditory nerve tissue isn't producing enough energy to function, well, there you go.


Hearing impairment is common in patients with mitochondrial disorders, affecting over half of all cases at some time in the course of the disease [3]. Although the final common pathway for the hearing loss is thought to involve ATP deficiency secondary to a biochemical defect of the respiratory chain, the clinical presentation of mitochondrial deafness varies considerably, both in terms of associated clinical features and of natural history. In some patients, deafness is only part of a multisystem disorder, often involving the central nervous system, neuromuscular system, or endocrine organs; in other cases, deafness may represent a feature of an oligosyndromic disease [4].

It also means that cell death is not regulated nearly as well; cells instead undergo alternative death pathways; necroptosis, pyroptosis, ferroptosis, parthanatos, et cetera, which are nasty and leave behind a big mess to clean up. Sometimes, cells need to die, and they need to die in an orderly manner. That's what apoptosis is for. The inhibition of apoptosis by reduced cytochrome C levels also makes tumor cells hang around longer, since the processes that would speedily annihilate those cells are now inhibited.



If these mRNA vaccines are, in fact, inhibiting mitochondrial function, I don't know what to tell people other than stop injecting children with motherfucking poison. Goddamn.
 
Oh. My. God. :stress:

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I can go into more detail about parts of this at least. There are several parts to mRNA. The two that are brought up here are basically the coding sequence (CDS) and the 3' untranslated region (3'UTR). The CDS is what is used to make the protein, and the 3' UTR is not used to make the protein but instead is meant to regulate the stability of the mRNA and regulate how much protein is made. There is another class of RNAs I have to mention as well: non-coding RNAs (ncRNAs). These are RNAs that do not make protein, but rather the RNA itself performs some sort of function. So it sounds like for AES they took the 3' UTR (which normally shouldn't make protein) and put it after the stop codon for the spike protein. As long as they didn't fuck it up, there shouldn't be a risk of the AES 3'UTR specifically fucking anything up. But it gets a lot more complex.

mtRNR-1 is one of those ncRNAs, specifically a type known as a ribosomal RNA (rRNA). Like I said, it has functions itself. This seems to me like a terrible idea to put into a mRNA. The big question I have is how much of the mtRNR-1 gene is in the sequence (based on the paper it sounds like 142 of the 959 nt, though the more important question is which nucleotides)? The mutations in this ncRNA actually change its structure and function, and it looks like that is how the mutations cause hearing loss (disclaimer, I can't read this whole article now for info beyond the abstract. If anyone wants I can try and get access later).So it sounds like Pfizer took some part of a ncRNA that can cause issues when mutated/modified, and threw it in with the spike protein sequence, not knowing how the spike protein sequence would affect the ncRNA sequence. This means that the mRNA itself may (emphasis on may) be dangerous. Could this result in the deafness? Possibly, though that would need research to be done. With the dangers of the spike protein and the reports of autoimmune disorders, I would honestly lean more towards the spike protein and immune response fucking up their hearing instead. But I can't believe that they wouldn't see an issue with putting ncRNA sequences into an experimental drug (or more likely they just ignored the potential issue).

Lastly I'll mention the pseudouridine. As a side note with the last paragraph, inserting pseudouridines can influence not only RNA stability, but RNA structure, which is again something you have to be incredibly careful about when working with a ncRNA, especially one where changes in structure result in pathologies. As for what is said in the post, it looks well supported that pseudouridine results in stop codon readthrough in yeast. My understanding is that they did not insert the pseudouridine at designated locations, and instead if they inserted it randomly into a stop codon then a bunch of extra junk may get turned into protein (though it is also very possible that the ribosomes could recognize something is wrong and abort making the protein altogether. It's impossible to say without knowing the sequence in question, which is why it's important to test these things). If that is the case, I would hazard a guess that we have little to no idea what would get made. Neither the 3' UTR of AES or any of mtRNR-1 are meant to be made into proteins. So you wouldn't really end up with spike+AES+MTRNR1, but rather spike+junk+junk, with the junk maybe being harmless or maybe being dangerous, we wouldn't have any idea without knowing what the junk is and studying what effects it had.

As for pseudoruridine, cytochrome c, and mitochondria, what you just posted is an excellent explanation and I don't think I need to make things more confusing by trying to overexplain it. Everything I just wrote is probably too much for a lot of people anyways though I'm happy to answer questions. It really seems like all bets are off for what these shots can do to people.
 
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