Mr. Metokur emitted a theory that really activated my almonds during his last stream with Paulyfrog64:
( I couldn't find the timestamp but it is during the last segment of the stream with the callers.)
Jim suggests that the reason why Nick is so resentful toward women is because he might have a small penis.
Having observed his general demeanor on his streams I couldn't help but remember of a guy that I knew back when I was in high-school, he looked like an average guy albeit of shorter stature than average.
But something that really differentiated him from the other guys was his feminine manners which reminds me a lot of Fuentes. Now here's the thing, that guy also was born with a twin sister (like Nick).
I'm not qualified in that domain, but I'm pretty sure that there are papers written about female/male dizygotic twins hormonal imbalance and the effect it has on their postnatal development.
I would like to confirm Jim's theory, but there's only one way of finding this out, which isn't at our disposal currently.
However if we observe the different aspects of Fuentes life including this biological factor, I think it is reasonable to speculate that he probably has under developed genitalia.
There aren't sufficient studies which explain how homosexual sexual preferences emerge in individuals, some speculate that it is genetic predispositions and other think that it is social/environment factors (it is likely a combination of the two), in Fuentes case, he clearly exhibits homosexual behavior without being aware, that's one of the few things he doesn't fake on his stream.