Some way through the Johnny Depp trial when it was becoming obvious that the long day and night streams were burning him out, he started a stream in an absolutely foul mood which he addressed up front, but said he would stream regardless refused to elaborate beyond it being "one of the worst days of his life". A more dedicated autist could probably go back and find the clip. I'll make some effort when I'm on my lunch, but no promises.
If you take him at his word it had nothing to do with his wife or kids, but it sort of cast a shadow for the rest of the Depp coverage for me. I thought it might have been gay-op Lawtube drama related or an issue with extended family at the time.
Take everything I've said with a grain of salt as I might be putting more importance on this than what it really deserves, but it's stuck out in my mind since it happened.