Anna o' Brien / Glitter + Lazers / GlitterandLazers - Fat, drunk, consoomer attention whore who would rather eat and drink herself to death than endure a single negative emotion

[blue gopher snakes]

I mean, just look at her. She’s an ogre. How many times in this thread have we done the funny FaceApp “gender swap” filter only for the filter to just give up and make Anna’s hair shorter because she’s already so freakishly masculine? I’m willing to believe this web-necked giantess absolutely has some underlying genetic fuckery.

 

[Tomato flowers]

I mean, just look at her. She’s an ogre. How many times in this thread have we done the funny FaceApp “gender swap” filter only for the filter to just give up and make Anna’s hair shorter because she’s already so freakishly masculine? I’m willing to believe this web-necked giantess absolutely has some underlying genetic fuckery.

The possible reasons for her being cagey about which gene specifically is borked are both multitudinous and hilarious. I pray one day she leaves a diagnosis-revealing piece of paper in view of the camera reflecting off her eyeball…

 

[The Queen of Autists]

I'm a day late, but:
View attachment 6980347

Her arms look identical here (despite her claims that she has loose skin now). After only removing I assume about 10 lb of fibrosis (if I recall, that's what was taken from her hips in one treatment), how are her quack doctors justifying a brachioplasty?

Every day she gets closer to Jacqueline Adan.
View attachment 6980353

i think to judge the arm fat correctly you have to look at where the rounded chunk of meet is at the top and where the cut off to the flap is, there is less of the arm meat but it looks bigger cause the flap is hanging more in my opinion. The flap used to be less saggy and therefore it looks like the arms are bigger cause it’s hanging long but if we looked at circumference there is less it’s like an optical illusion.

Spoiler: One sentence power level

I have been able to wear a normal size blood pressure cuff on upper arm instead of the plus sized one but just checked in mirror and my arms do look bigger when hung in that position due to the sagging of the hanging skin so it checks out in real life. We would need to find a way to figure out circumference rather than surface area if that makes sense.

Re: the thing being genetic fat I’m sure it was probably this quack Dr that told her it was maybe after doing some fake quack genetic test they charged her a bunch of money for. They are butchering her they know she’s dumb and are liable to do anything they can get away with. They are performing surgery in what has the set up similar to a dental office when it comes to sterility.

Re: twilight sleep: you feel every single thing you just don’t remember you felt it later. That helps avoid the trauma mentally but you still FEEL it all, it’s still horrific pain she’s going through. They use datura/scopolamine in Haiti to make people believe they are dead zombie and turn them into slaves. They are walking and talking and everything but believe they are dead and kind of out of it.

 

[Potatis Salad]

It’s interesting she will tell everyone she has rare obesity genes but cannot tell you what genes she is talking about. There are actual genetic disorders like POMC deficiency due to specific mutations with the POMC gene. There is the monogenic obesity panel, is that the one she had before?

(Monogenic just means a single gene, some disorders only need one mutated gene to cause disease while others require two)

The thing about the disorders tested for on the monogenic obesity panel is they all have pretty severe issues such as intellectual disability, polydactyly, eye issues, kidney issues and so on. These are actually pretty awful genetic disorders. If Anna believed that she could have any of those without zero symptoms or clinical signs, she really has no critical thinking skills.

I’m curious as to what person/university/genetics dept is supposedly studying her genes and in what capacity, because Anna never elaborates on it.

She did elaborate on it. She did a genetic test called the Rare Obesity Gene Panel which, as you correctly guessed, was not a gene study performed at an academic hospital. It was a screening test performed by a pharmaceutical company, trying to identify candidates to sell their drug (Imcivree) to. She did not have either of the two candidate genetic conditions, but she started claiming "rare genes" after the test. I think they likely found a VUS.

Rhythm Pharmaceuticals, the pharmaceutical company who did her genetic testing, also operates this website mentioning more genetic cundishuns related to obesity (the "additional diseases" (archive of page) are SRC1 deficiency and SH2B deficiency):

As I said in my older post about this (linked above), POMC deficiency and Bardet-Biedl syndrome are the two conditions that Rhythm Pharmaceuticals was hoping to identify because they are treatable by Imcivree. More diseases from this list were likely included in the Rare Obesity Gene Panel that Anna received.

EDIT: Here's the link to Syo's archive of Anna talking about the Rare Obesity Gene Panel. She talks about her own results in the fifth video down (the 0:29s one). @TheCakeIsALie, do you agree that it's giving VUS?

 

[TheCakeIsALie]

@Potatis Salad, appreciate this. In the video she said she doesn’t know if it’s one gene or multiple, then says it's only says two genes and no mention of what was found, where/ location etc. If anyone knows if a specific gene was mentioned, please let me know because there are gene mutation databases I can sift through.

The average person is a carrier for 3 to 5 genetic syndromes/disorders.

Every single one of us has tons of variants. The majority of which is harmless. Which is why direct to consumer testing like Nebula and 23andme is despised in the genetic community. It’s very easy to misunderstand snps

I am attaching my report I got back which explains the VUS found during testing and what it means, and to also show what an actual diagnostic report looks like so people can understand how information is interpreted clinically since it’s important to always look at the clinical context

in this case, it’s referencing ATRIP-deficient Seckel syndrome, a type of primordial dwarfism. Seckel is recessive, so it requires two copies of a mutation and a 25 percent chance a child would get it. It seems my child is a potential carrier, but this variant has never been reported in literature with known cases, so it’s unknown if it causes disease.

When talking about VUS, it’s important to not make assumptions, esp in the absence of any clinical picture. If Anna has a VUS, she should be ignoring the data unless an actual clinical geneticist or researcher with a phd in genetics says something. There’s a reason genetic counselors exist and if she has never been to one then likely it’s all bull, even if a VUS was found.

Given she still didn’t mention the chromosome or any actual details it’s hard for me to tell if this is legit or not. I’m leaning toward not until I see proof otherwise somewhere. A layperson should not be trying to interpret their own data and maybe that’s what happened, she got some snp report and is misinterpreting what it means.

A legit report would include what I showed so I wonder why she has not shown the paper or made very specific references unlike most genetic testing reports. Maybe she was told the result isn’t relevant but she’s twisting it in her mind to mean she could have something

She isn’t doing this for others, either. Most people with rare syndromes want to raise awareness and do good. Anna’s motives are very different. She wants something to be wrong so she can justify her eating

It’s also unusual she never talks about anything occurring in childhood health wise other than being fat. Rare disorders tend to be apparent from birth or early childhood. Growth issues, feeding issues, something. And most rare syndromes are pretty devastating. TRPS 1 is “mild” but still causes issues. So I do not think she has a genetic disorder at all. I think an snp or VUS was found and Anna is jumping to conclusions.

 

[ghjoigcbn]

looking back at the video it does seem plausible that they found a VUS. And when they explained it to her, in her mind abnormality in a obesity genetic panel that we don’t know about = super rare obesity gene that is too rare and special to be studied. She even says in the video they dont know what it was or how it works. We have a lot of evidence that she has difficulty with comprehending and following these sorts of technical conversations so I think it is very plausible.

And it gives her the perfect excuse because “it’s so rare no one has looked into” means it cant be disproven. Even though it could be a completely harmless mutation.


Thanks for sharing your expertise and bringing these videos up again! @Potatis Salad @TheCakeIsALie

 

[GenociderSyo]

 

[TheCakeIsALie]

View attachment 6986109
View attachment 6986113View attachment 6986122
View attachment 6986134View attachment 6986136

It was ai, but with a very specific method with proven accuracy. This wasn’t webmd or ChatGPT. It was face2gene and while it did come up with a match it’s important to know that I also looked at clinical journals to see if the result made sense. Not only that but face2gene has a heat map and my heat map matched exactly with the composite photo. You also have to have an account approved and be a provider or work in healthcare first to even get access. It’s a clinician tool.

Once I saw the clinical journals of people like me with the same exact features, I knew this was the answer.

 

[Nomorepls]

If I was Anna, and was able to defy physics due to a super rare gene, I would want to prove the haters wrong, do my bit for science, and do a super accurate video food/exercise diary.

If it did show that she was indeed sticking to under 2000 calories a day, walking/running several miles, but still piling on a huge amount of weight (especially given her current size), imagine how many doctors would commit their careers to helping her. She would genuinely be a medical mystery.

There may well be something at play impacting her ability to lose weight, whether that is inflammation, hormones, fluid retention, the Lymphedema, or a mixture of all the above, but there's absolutely no way that accounts for all 500+ pounds of her. It shocks me to my core that Anna has obviously convinced herself that all of her extra weight is caused by illness, not by diet, and I just think that's a terrifying prospect with an insane amount of mental gymnastics. I don't think she has ever actually confirmed numbers in regards to weight loss/gain either, which says something.

And what's even more mad is how she presents this to the world - that she's genuinely defying physics, and is this rare specimen that people should marvel at, given how strong she is as a person.

Meanwhile the world is watching, knowing that if she just stopped drinking, ordering more than one hot dog at a time, and eating tens of thousands of calories on holiday, she's stand a chance of losing the weight without having to be butchered.

It's said a lot on this site but I would absolutely love to see a genuine food diary from this cow.

 

[Otterly]

She never uses anything like pathogenic, non pathogenic, VUS, or any genetic lingo to describe *what* was found exactly.

do you agree that it's giving VUS?

Yeah. Oddly this is my special subject…
the study of human genetic variation is very interesting. We all have a bunch of genes, and there can be variations in the sequence of them, some more than others. Those variations can mean all sorts of things
- Codins, which are three letters of DNA, get read into sequences of amino acids which then fold up to make proteins. Some variations don’t actually cause a change in the amino acid sequence at all - so they are completely silent. Both GAA and GAG mean ‘stick a glutamic acid there.’ So an A to G mutation means no change in the protein.
Some cause such a minor change it means nothing. Some cause a catastrophic change that terminates or fucks up the protein completely, and there’s every shade in between. So a mutation can mean anything from nothing whatsoever, so a tiny difference, so something very damaging.
She’s likely come up with some slight polymorphism in one of the genes on that panel. When we make these panels we include the known variants that cause known problems, and because it’s cheap these days we chuck all known variants in as well. It’s like a chip with little bits of code stuck on it and you wash it with your own RNA or DJA depending which type. Each probe binds it’s opposite strand and lights up if it catches anything.
If actual sequencing has been done you look at the sequence itself rather than fishing for it with specific probes.
A report, as the poster above attached, will list out those variations and it’ll give the geneticists take on them. You might find a sequence that you know is proven to cause a specific syndrome, or you might find a VUS. Vegan Anna (fit vegan ginger) has one of these in a CF gene and claims she has CF. She doesn’t have CF. Anna doesn’t have pathogenic variations or she’d have been offered the drug.

 

[Cuntspiracy Man]

It was ai, but with a very specific method with proven accuracy. This wasn’t webmd or ChatGPT. It was face2gene and while it did come up with a match it’s important to know that I also looked at clinical journals to see if the result made sense. Not only that but face2gene has a heat map and my heat map matched exactly. You also have to have an account approved and be a provider or work in healthcare first to even get access. It’s a clinician tool.

what AI of this sort does, whether it be ChatGPT or their own personal network, is 'spot' commonalities in writing and replicate them, if X is commonly written next to Y, it will do the same
this is why AI feels "smart" to people who don't understand how it works, and why it's oftentimes 'correct' and other times 'wrong', because aside from human writing also being sometimes right and sometimes wrong, it also doesn't see info, it just repeats words that we logically correlate with info
ChatGPT doesn't know why what it said is "right", it can't explain it other than, again, copy the manner in which past explanations by humans were written, it doesn't comprehend it, it just read enough papers to see the same sentences and rationalizations next to one another, so when it goes on blabbing that into a sentence we trick ourselves into thinking it understood what it read, when it just repeated it

when the machine has access to every piece that has ever been written, it will simply start writing the same way, it's copying human observations and doesn't discover anything by itself
public access AI is 'dumber' because it simply has access to more different sources of information than AI in a closed system that is only fed curated info

in such AI is at best just the more automated and vocal variant of the 'coder's duck', at most it throws info humans discovered back at them until something in our heads clicks because we are bound to miss something due to being human that we might notice and correct if we have something to explain it to
it's a duck that talks back

 

[Otterly]

Face2gene is a really fun program and I wish i still had access to it because I keep seeing cows in here and thinking ‘hmmmmmm…that kinda looks like…’

 

[Nomorepls]

It was ai, but with a very specific method with proven accuracy. This wasn’t webmd or ChatGPT. It was face2gene and while it did come up with a match it’s important to know that I also looked at clinical journals to see if the result made sense. Not only that but face2gene has a heat map and my heat map matched exactly with the composite photo. You also have to have an account approved and be a provider or work in healthcare first to even get access. It’s a clinician tool.

Once I saw the clinical journals of people like me with the same exact features, I knew this was the answer.

Not to PL or draw attention to your identity but I just want to say, I found your episode fascinating and I think it's incredible what you've achieved for you and your son by continuing to search for an answer. Not to mention what this meant for all the other individuals experiencing the same thing, and how you helped them to find answers too.

I think Anna's episode was a crock of shit and purely self-indulgent, but your story was very valuable and genuinely inspiring to hear. I also loved the way you delivered it - your attitude was really refreshing.

 

[Barbarella]

Not to PL or draw attention to your identity but I just want to say, I found your episode fascinating and I think it's incredible what you've achieved for you and your son by continuing to search for an answer. Not to mention what this meant for all the other individuals experiencing the same thing, and how you helped them to find answers too.

I think Anna's episode was a crock of shit and purely self-indulgent, but your story was very valuable and genuinely inspiring to hear. I also loved the way you delivered it - your attitude was really refreshing.

I agree. I just cant help but be sad Anna was involved. It was like casting pearls before swine. I hope Kevin Pho or somebody real can get your story out there. You clearly learned a lot and tell it well, and you can help others learn to do what you did. Anna was only there looking for breaks to talk about herself, but you were good at breezing past it.

 

[TheCakeIsALie]

@Cuntspiracy Man, face2gene uses gestalt ai and uses a database of syndromes and will match facial features.

Here’s a study about it: https://onlinelibrary.wiley.com/doi/10.1002/ajmg.a.63459

I did contact KevinMD, no reply yet.

 

[Cuntspiracy Man]

@Cuntspiracy Man, face2gene uses gestalt ai and uses a database of syndromes and will match facial features.

Here’s a study about it: https://onlinelibrary.wiley.com/doi/10.1002/ajmg.a.63459

I did contact KevinMD, no reply yet.

thanks for the info
point is it still uses research that people have done, just detects patterns that people have already detected in the past and instructed it to detect
it's so dumb when normalfags like anna who don't understand what AI is just see it as a magical lazy people tool because you know she doesn't comprehend what actually occured here, in her mind she just thinks "wowie da compooter did a magic!"

 

[GenociderSyo]

If I had to see how far up Anna's ass her thong was you all do as well.

 

[thejackal2]

View attachment 6986109
View attachment 6986113View attachment 6986122
View attachment 6986134View attachment 6986136

I'm sorry but everybody involved in this episode is off their rocker a bit. Including our farmer (who has quite the reddit account) with the thick ass Long Island accent that appears to be sitting in Miss Havisham's attic. Who really gives a fuck if Anna has some genetic disposition to being fat? She lost weight before, she can do it again. She is a cow and delusional regardless.

 

[TheCakeIsALie]

I'm sorry but everybody involved in this episode is off their rocker a bit. Including our farmer (who has quite the reddit account) with the thick ass Long Island accent that appears to be sitting in Miss Havisham's attic. Who really gives a fuck if Anna has some genetic disposition to being fat? She lost weight before, she can do it again. She is a cow and delusional regardless.

I can assure you, I am not off my rocker. Wanting an answer for five generations of family members that suffered with specific symptoms and wanting answers for a full term baby failing to grow and develop properly as a parent is not unreasonable.

I am sorry if my Li accent was too much, but what happens is a lot of parents here come from Queens and the boroughs like my mom and that’s what ends up happening. I also filmed in my bedroom with terrible lighting because I have vision issues and need a lot of light to see.

You don’t have to like me, what I say or what I do. But I already admitted to mistakes such as choosing to go on Anna’s podcast since I was unaware of better ones. I’ve taken the advice of others here. It’s easy to sit here and judge when you’re not in the position I was in.

 

[-Jack-]

I can assure you, I am not off my rocker. Wanting an answer for five generations of family members that suffered with specific symptoms and wanting answers for a full term baby failing to grow and develop properly as a parent is not unreasonable.

I am sorry if my Li accent was too much, but what happens is a lot of parents here come from Queens and the boroughs like my mom and that’s what ends up happening. I also filmed in my bedroom with terrible lighting because I have vision issues and need a lot of light to see.

You don’t have to like me, what I say or what I do. But I already admitted to mistakes such as choosing to go on Anna’s podcast since I was unaware of better ones. I’ve taken the advice of others here. It’s easy to sit here and judge when you’re not in the position I was in.

Your information and the sharing of your experience with Anna and the podcast is greatly appreciated and insightful, but I think this is where it ends before you start PLing too much, you seem like a nice lady.

Anna is fat and lazy, and I would not have sex with her.