Victor Markhoff / Ana Victoria Markhoff / vvictorman_uel - Powerchair faker pooner, has every illness, allergic to Krebs cycle, bed mayo enjoyer, kicked out of house and mental hospital, constant ebeggar, applesauce heiress paid to yeet her teets

[Catch The Rainbow]

Ew.

View attachment 7706865

Joining the "genetics are inherently a Nazi concept" discourse, I guess.

View attachment 7706866

"I forgot I don't produce man juice"

My theory is that Twitter has been memeing about the effect zinc supplements have on semen production, she saw it and wants to participate somehow but can't so this is her cope

 

[Zemblan Physics]

She spoke to the manager advocated for herself until she got the diagnosis she’s been chasing, it seems. Is there no justice in this world?

Well, if she’ll eat everything twice, at least we can enjoy her becoming FATTER & GAYER. So at least there’s that.

 

[Catch The Rainbow]

Vicky is once again making the death of an internet rando a friend about herself.
View attachment 7711808
She REALLY wants to go the service.
She does, however, have priorities. View attachment 7711814
Much friendship.

ETA: apparently, this is Ziggy, an anti-Zionist Jew and hipster rabbi or something. Waow.
View attachment 7711835

I knew Ziggy. Leftist who used Chassidus to push his politics and valued his race over his religion. We argued a few times and his hatred for anyone who didn't agree with him was white hot.

https://zeinshver.wordpress.com/2014/01/27/i-hate-this-word/

I despised him and I hope he finds the peace that he never had in life.

I guarantee she never met him IRL and she's just mourning him for the attention.

 

[AfghanBlue]

She spoke to the manager advocated for herself until she got the diagnosis she’s been chasing, it seems. Is there no justice in this world?
View attachment 7715099
Well, if she’ll eat everything twice, at least we can enjoy her becoming FATTER & GAYER. So at least there’s that.

"Looking forward to" is doing a lot of optimistic work here

I wager she hasn't been diagnosed with shit and didn't hear anything of note from the cardiologist either, hence the fact she hasn't blatehred it all over. She's just dreaming dreams of gravis.

She also seems to be chucking some low effort gasoline on some grim munchie fire elsewhere on twitter..

That's her retweeting some self diagnosed adhd and occasional tummy ache dIsAbLeD bitch saying "you should totally not tell twitter strangers to quit ripping apart a grieving mother"

Basically it looks like some spoonie died, moments after venting about her mum, who logged in and deleted her slagging tweet, because she was getting heat, twitter dogs attack even more because of it

This person

Their ma posting on the account :


Vicky seems to say she knows all these people. They generally, as an ilk, certainly don't really interact much except to offer the most cut and paste "omg disgraceful you deserve better!"/ "have you considered gastroparesis?" shit back and forward at eachother.
Perhaps they dm here and there but I can't imagine it being much more than bot level communication of rants between extremely self centered people about barely understood hyochoncriac lists of aches, pains and paranoia.
Then they retroactively craft this into a relationship with good times.

 

[CyberInu]

Homeboy got 2 whole mentions. She must've really liked him to only talk about herself 11 times.

 

[Diana Moon Glampers]

It still baffles me how hard she pursues corticosteroids.

 

[Larry David's Opera Cape]

It still baffles me how hard she pursues corticosteroids.

I have a wild theory. Let me ask grok something...

Prednisone is a corticosteroid primarily used to treat inflammation, autoimmune disorders, and other medical conditions by mimicking cortisol’s effects. Misuse of prednisone by a mentally ill patient could stem from several motives, though the drug’s psychoactive effects and interactions with drugs of abuse, including opioids, are limited and specific. Below is a detailed breakdown based on available medical knowledgeotential Motives for Misuse by a Mentally Ill PatientSelf-Medication for Mood or Energy Boost:

• Prednisone can induce euphoria, increased energy, or a sense of well-being in some individuals, particularly at higher doses. A patient with mental health conditions like depression or bipolar disorder might misuse prednisone to self-medicate, chasing these mood-elevating effects.
• Conversely, those with anxiety or psychotic disorders might misuse it due to distorted perceptions of its benefits, driven by compulsive behavior or delusional beliefs about its effects.
• Misguided Attempts to Manage Physical or Psychosomatic Symptoms:
  • Patients with somatic symptom disorders or hypochondriasis might misuse prednisone, believing it will alleviate perceived physical ailments (e.g., inflammation or pain) that are psychosomatic in nature.
  • Those with body dysmorphic disorder or eating disorders might misuse it for perceived weight loss or anti-inflammatory effects to alter appearance.
• Compulsive or Addictive Behaviors:
  • Individuals with obsessive-compulsive tendencies or substance use disorders might misuse prednisone as part of a broader pattern of compulsive drug-seeking behavior, even if the drug’s effects are not strongly rewarding.
  • In rare cases, patients with a history of steroid misuse (e.g., anabolic steroids) might confuse prednisone’s effects with those of other steroids, seeking performance enhancement or physical changes.
• Cognitive or Delusional Misinterpretations:
  • Patients with schizophrenia, bipolar disorder, or other psychotic conditions might misuse prednisone due to delusions about its effects (e.g., believing it enhances mental clarity or physical strength).
  • Cognitive distortions in conditions like borderline personality disorder could lead to impulsive misuse during emotional crises.
• Psychoactive Effects of PrednisonePrednisone is not a classic psychoactive drug, but it can have significant neuropsychiatric effects, particularly at high doses or with prolonged use. These effects are generally considered side effects rather than therapeutic:
• Euphoria or Mood Elevation: Prednisone can cause euphoria or a “high” in some users, likely due to its effects on glucocorticoid receptors, which influence dopamine and serotonin pathways indirectly. This may be appealing to those seeking mood alteration.

• Mania or Hypomania: In susceptible individuals (e.g., those with bipolar disorder), prednisone can trigger manic or hypomanic episodes, characterized by elevated mood, irritability, or reckless behavior.
• Anxiety and Agitation: Prednisone can increase anxiety, restlessness, or agitation, potentially exacerbating pre-existing anxiety disorders.
• Psychosis: High doses (e.g., >20 mg/day) or prolonged use can induce steroid psychosis, marked by hallucinations, delusions, or disorganized thinking, particularly in those with a predisposition to psychotic disorders.
• Cognitive Effects: Prednisone may cause difficulty concentrating, memory impairment, or confusion, which could be misinterpreted by a mentally ill patient as desirable or therapeutic.
• Insomnia: Prednisone often disrupts sleep, which could exacerbate mental health symptoms or contribute to misuse in an attempt to self-regulate energy levels.

These effects are dose-dependent and more pronounced with long-term or high-dose use. However, prednisone lacks the direct rewarding properties of typical drugs of abuse (e.g., opioids, stimulants), making it less likely to be misused for recreational purposes.Enhancement of Common Drugs of AbusePrednisone does not significantly enhance the effects of most common drugs of abuse (e.g., cocaine, amphetamines, cannabis, alcohol) in a direct pharmacological sense. However, its effects on mood and energy could indirectly influence the subjective experience of other substances:

• General Considerations:
  • Prednisone’s mood-elevating effects might amplify the perceived euphoria of stimulants or other psychoactive drugs in some users, though this is not well-documented.
  • Its potential to cause agitation or anxiety could exacerbate the negative effects of stimulants or hallucinogens, leading to unpredictable outcomes.
  • Prednisone’s impact on metabolism (via cytochrome P450 enzyme induction) may alter the metabolism of certain drugs, potentially affecting their potency or duration, but this is not specific to drugs of abuse.

Interaction with Opioid DrugsPrednisone’s interaction with opioids is primarily pharmacokinetic and clinical rather than synergistic in terms of abuse potential. Key points include:

• Pharmacokinetic Interactions:
  • Prednisone is metabolized by the liver, primarily via cytochrome P450 3A4 (CYP3A4). Some opioids, like oxycodone, hydrocodone, methadone, and fentanyl, are also metabolized by CYP3A4. Prednisone may induce CYP3A4 activity with chronic use, potentially reducing the plasma levels of these opioids, leading to decreased efficacy or withdrawal symptoms in dependent individuals.
  • Conversely, acute prednisone use is unlikely to significantly alter opioid metabolism.
• Pharmacodynamic Interactions:
  • Prednisone does not directly enhance the euphoric or analgesic effects of opioids. However, its mood-elevating effects could theoretically amplify the subjective “high” in some users, though this is not well-supported by evidence.
  • Prednisone’s side effects (e.g., agitation, insomnia) could counteract the sedative effects of opioids, potentially leading to discomfort or increased opioid dosing to overcome this.
• Clinical Risks:
  • Gastrointestinal Effects: Both prednisone and opioids increase the risk of gastrointestinal side effects (e.g., ulcers, bleeding). Concurrent use could heighten this risk, especially in chronic misuse scenarios.
  • Immune Suppression: Prednisone suppresses the immune system, which could exacerbate risks in opioid users, who are already prone to infections (e.g., from injection drug use).
  • Adrenal Suppression: Long-term prednisone use suppresses the hypothalamic-pituitary-adrenal (HPA) axis, which could complicate opioid withdrawal, as both conditions stress the adrenal system.
  • Cardiovascular Risks: Both drugs can increase blood pressure or fluid retention, posing additive risks for cardiovascular complications.
• Abuse Potential:
  • There is no evidence that prednisone enhances the rewarding properties of opioids or increases their abuse potential. Misuse of prednisone in combination with opioids is more likely driven by underlying mental health issues or attempts to self-medicate physical symptoms (e.g., pain) than by a desire for synergistic psychoactive effects.

Summary

• Motives for Misuse: Mentally ill patients might misuse prednisone to self-medicate mood, energy, or psychosomatic symptoms, driven by euphoria, compulsive behaviors, or delusional beliefs. However, its abuse potential is low compared to typical drugs of abuse.
• Psychoactive Effects: Prednisone can cause euphoria, mania, anxiety, or psychosis, particularly at high doses, but these are side effects rather than primary effects sought recreationally.
• Enhancement of Drugs of Abuse: Prednisone does not significantly enhance the effects of common drugs of abuse, though its mood effects might subtly influence subjective experiences.
• Opioid Interactions: Prednisone may reduce opioid efficacy via CYP3A4 induction but does not enhance their euphoric effects. Concurrent use increases risks like gastrointestinal complications and immune suppression.

If you have access to specific patient details or need further analysis of prednisone misuse in a particular context (e.g., a specific mental health diagnosis or opioid type), I can tailor the response further. For real-time data or case studies, I can also search the web or X posts if requested.
Prednisone, a synthetic corticosteroid, does not directly bind to or act on dopamine receptors in the brain. However, it can indirectly influence dopamine systems through its effects on glucocorticoid receptors and broader neurochemical pathways. Below is a concise explanation of its potential impact on dopamine based on available medical knowledge:Indirect Effects on Dopamine

1. Glucocorticoid Receptor Modulation:
   • Prednisone mimics cortisol by binding to glucocorticoid receptors (GRs), which are widely distributed in the brain, including areas like the prefrontal cortex, hippocampus, and striatum, which are involved in dopamine regulation.
   • Activation of GRs can modulate dopamine release and signaling indirectly. For example, glucocorticoids can enhance dopamine release in the nucleus accumbens, a key reward center, which may contribute to the euphoria or mood elevation some users experience.
2. Stress and Dopamine Interaction:
   • Glucocorticoids like prednisone influence the hypothalamic-pituitary-adrenal (HPA) axis, which regulates stress responses. Stress hormones can increase dopamine release in certain brain regions, particularly under acute administration, potentially leading to heightened arousal or mood changes.
   • Chronic prednisone use, however, may dysregulate the HPA axis, potentially altering dopamine sensitivity over time, though this is less well-characterized.
3. Neuropsychiatric Effects:
   • Prednisone’s ability to induce euphoria, mania, or psychosis in some individuals (especially at high doses, e.g., >20 mg/day) suggests an indirect effect on dopamine pathways. These effects may arise from glucocorticoid-mediated changes in dopamine transmission or interactions with other neurotransmitters like serotonin, which can modulate dopamine activity.
   • For example, studies in animal models show that glucocorticoids can increase dopamine release in the mesolimbic pathway, which is implicated in reward and motivation.

No Direct Dopamine Receptor Binding

• Prednisone does not act as an agonist, antagonist, or modulator of dopamine receptors (D1, D2, etc.). Its effects are mediated through glucocorticoid receptor signaling, which secondarily influences dopamine and other neurotransmitter systems.
• Unlike drugs of abuse (e.g., amphetamines or cocaine), which directly increase dopamine by blocking reuptake or promoting release, prednisone’s effects are less potent and not typically rewarding enough to drive recreational misuse.

Clinical Implications

• Mental Health Conditions: In patients with pre-existing dopamine-related disorders (e.g., schizophrenia, bipolar disorder), prednisone’s indirect effects on dopamine may exacerbate symptoms like mania or psychosis, particularly at high doses or with prolonged use.
• Dose Dependency: Dopamine-related effects are more pronounced at higher doses (e.g., >40 mg/day) or with chronic administration, where glucocorticoid-induced changes in brain chemistry become more significant.

SummaryPrednisone does not directly affect dopamine receptors but can indirectly influence dopamine release and signaling through glucocorticoid receptor activation and HPA axis modulation. These effects may contribute to neuropsychiatric side effects like euphoria or mania but are not comparable to the direct dopamine agonism seen with drugs of abuse. If you need more specific details (e.g., for a particular patient population or dose range) or want me to search for recent studies or X posts on this topic, let me know!Disclaimer: Grok is not a doctor; please consult one. Don't share information that can identify you.

 

[Idiosyncratic]

It still baffles me how hard she pursues corticosteroids.

Me too. I’ve had to take it a couple times due to a chest infection causing bonkers asthma and sure I stopped coughing but holy shit I was just grumpy as hell. Like MATI except the internet was real life.

 

[glioblastoma multiforme]

Who wants to pay $30k a year to educate an average kid?

It gets your average kid opportunities that would never be available to them through comprehensive schools.

Just look at the UK- David Cameron and Boris Johnson went to Eton then Oxford then led the country. They are not exactly bright. But what they got at Eton was being coached intensitvely on how to perform well in exams and at interview, they will have had better teachers. They know the unspoken rules of how not to mark yourself as an outsider in certain circles, like not wearing brown shoes to an investment banking interview, are learned. They made contacts with other rich families from all over the world.

That's part of why there is such an imbalance in the number of people who went to private schools going to elite universities.. I went to a private school for a few years and a frightening number of not that bright people from there got into Oxbridge.

Sending an average kid to a private school probably gives them a better chance at being financially successful in later life than sending a bright kid to a public school.

Also, for the likes of Vicky's parents, I can't imagine them wanting their children to be socialising with "poor people" or wanting "commoners" to be invited to their home.

I could sperg forever on this topic. Obviously the investment was wasted on Vicky anyway.

 

[MirnaMinkoff]

could sperg forever on this topic. Obviously the investment was wasted on Vicky anyway.

It was being sarcastic with that statement.

 

[Zemblan Physics]

She’s on the severe end of the famous myasthenia gravis spectrum, you guys. That’s why she’s in the upside down chair, for real.

Give me strength. Also, lol at the reply person who just noped out when she realized she was interacting with a sped.

 

[The Jewel of the Nile]

>I don't know what treatment is most appropriate
EXTREMELY RARE Vicky admitting to not knowing it all. Better archive that response fast!

 

[glioblastoma multiforme]

She’s on the severe end of the famous myasthenia gravis spectrum, you guys. That’s why she’s in the upside down chair, for real.
View attachment 7717574

She's still peddling her possibly involved antibody as definite proof.

Why do munchies always want to be on the severe end of things? The rest of us are happy when whatever health problem has forced us into the presence of medics is described as "uncomplicated" or whatever.

Its not enough to get whatever shiny diagnosis they're chasing. It has to be the worst case the doctors ever seen. Its not more virtuous to be a lazy fat attention seeking slob when you have a worse than average case of something if that thing at any severity doesn't prevent you from carrying out standard activities like cleaning and cooking.

Its probably been said already, but I think I've figured out why she wants the MG:

https://www.nhs.uk/conditions/myasthenia-gravis/treatment/

Common triggers include:

• tiredness and exhaustion – getting plenty of rest and not overexerting yourself may help
• stress – read some tips to help reduce your stress levels

 

[Diana Moon Glampers]

She wants any reason at all to explain her total failure to thrive that isn't "combination of deconditioning and drug abuse."

That's all there is to it.

Normies usually won't know anyone else with the same condition or think to check up about expectations of that condition online. If she says yeah, I have it, it's on the severe end which is why I use a power chair...99% of normies will never even question it, even if they happen to know another person with the same condition, because maybe the guy you knew just had a mild case and it'd be too intrusive to ask. Even people who had heard of the condition would say wow I didn't know it could be that bad, and go on with their day. It's only autistic detectives who have immediate skepticism flags go up.

 

[Uncle Tom's Condo]

Me too. I’ve had to take it a couple times due to a chest infection causing bonkers asthma and sure I stopped coughing but holy shit I was just grumpy as hell. Like MATI except the internet was real life.

100%. Abusing prednisone is such a bizarre concept. At least opioids or adhd meds do something 'fun' when you misuse them.

Spoiler: PL lol no1curr

I had to take a 30 day course once when some autoimmune shit flared from stress when I was at the lowest point in my life. I laid in bed at night and would sweat like a gypsy the day before rent was due. I also ended up smashing my keyboard over my desk at work and stormed off. Bad stuff. Not pleasant at all. It did work, however.

 

[AfghanBlue]

Me too. I’ve had to take it a couple times due to a chest infection causing bonkers asthma and sure I stopped coughing but holy shit I was just grumpy as hell. Like MATI except the internet was real life.

Weird. I had a nerve root block injection of steroid plus anesthetic for a nasty back/hip/joint shitty-chronic-mystery style issue, and felt much better .
It turned out that it wasn't that effective, aside form the steroids, cos when they repeated it without steroids, it didn't really help.

Doctor said "if I injected your leg it would make your back feel better, the steroid will boost people"
So maybe she likes it for that? But she doesn't do... - anything- you would expect with that steroid boost for pain. Get active or whatever.

Perhaps they are totally and massively different. It's a mystery area for me. Even if it's the feel good type, being a moonface weirdo would defo tip my own personal scales on that trade off tho, irdk.

 

[The Judean People's Front]

Weird. I had a nerve root block injection of steroid plus anesthetic for a nasty back/hip/joint shitty-chronic-mystery style issue, and felt much better .
It turned out that it wasn't that effective, aside form the steroids, cos when they repeated it without steroids, it didn't really help.

Doctor said "if I injected you leg it would make your back feel better, the steroid will boost people"
So maybe she likes it for that? But she doesn't do... - anything- you would expect with that steroid boost for pain. Get active or whatever.

Perhaps they are totally and massively different. It's a mystery area for me. Even if it's the feel good type, being a moonface weirdo would defo tip my own personal scales on that trade off tho, irdk.

Everyone reacts differently to a round of steroids, just like everyone can get different side effects from the same medication. Some people barely notice the steroids/only notice the good effects, others get all the bad side-effects.

Years ago I did 5 days of Prednisone, iirc, when I didn't notice some poison oak on the riverbed during a hike. I wasn't even on a high dose, and I was goddamn miserable; just seething with anger over everything and sweating buckets.

 

[Not_a_Doctor]

I have been catching up on this thread for the past couple of weeks and it has been GOLD. Vic is batshit insane and so unlikeable I feel absolutely no remorse for gawking at her failure to thrive. She is so OTT. My favourite claims:

• NYU was “privileged” to have her as a disabled student when she clearly doesn’t read or have any leading edge thoughts or theories on anything of relevance.
• Utterly horrifying transformation from pretty, svelte girl to overbaked potato.
• Claims she needs streaming service to “stay alive” as if Netflix was oxygen.
• Doesn’t say thank you when people open doors for her and is generally a smug twat.
• HOW THE FUCK CAN YOU BE ALLERGIC TO ELECTROLYTES YOU LITERALLY NEED THEM TO LIVE?!?!
• Claims that doctors are talking to “the most affected person they will ever encounter”. Yeah, affected with arrogance and a crippling case of Dunning Kruger.
• Allergic to pred, but desperately wants and needs pred?!
• Thinks she has IBD, then autoimmune, and now MG but no rheum seems eager to treat her. She knows you don’t fuck about with autoimmune disease, right? Like, if she was actually dying they would be getting her on massive emergency doses of pred to suppress her immune system before it killed her?
• “I don’t want to be taken off life support even if I am in a vegetative state because I think caring for a person in the community is the most beautiful thing there is”. Fuck, she is so deluded. She absolutely needs to volunteer at a nursing facility and see the reality of people on long -term life support, literally wasting away while their loved ones come and see them out of love, then guilt, then less as life inevitably moves on.
• Her accommodations list from her stint in Florida is insane. Why does she claim she can’t walk and needs the power chair? I’ve forgotten already!
• Wants to be an academic. LMAO I would love to see her try and balance a full teaching schedule, writing papers, presenting and networking at conferences, applying for funding grants, and participating in college admin all while being massively underpaid. She can’t even submit an undergrad essay successfully.
• How did she almost die from being homeless? She’s never slept on the streets, never gone hungry for more than a few hours, never been without an internet connection.
• Claims of being “within a couple of minutes of death” all the time. No, you were not! You did not die because you were not dying!
• So frustrated with her criticism of her parents. She is lucky to have a family - lots of people have their parents die young and don’t have the luxury of a trust fund to fall back on. She is so ungrateful for the privilege in her life.
• Clearly has never experienced anaphylaxis and would not be live tweeting through it. Flushing is not a reason for an epi!
• Doesn’t eat any food that is at all advised for gastroparesis.
• Allergic to citric acid! ROFL she is batshit insane.

I look forward to future lols. If anyone can recommend similar threads I would be grateful- already on the munchie one.

 

[Greedy Fly]

If anyone can recommend similar threads I would be grateful- already on the munchie one.

The OG, Adjustable Jaquie, is a must-read if you haven't already. Witness the mold from which all these POTS/EDS/MCAS girls were cast.
A few of my less-textbook favorites are Jameela Jamil (covered in bees), Christine Milneaux (deep in the Victorian waif larp), and Kelly Ronahan (horrifying).

 

[Womb Wizard Victim]

If anyone can recommend similar threads I would be grateful

I also recommend Steph Cianfriglia if you've not discovered that thread yet. Same failure to launch, same batshit insanity.

Thread 'Stephanie Cianfriglia / Sapphire Crimson Claw / Yarrow Brown / the-ghost-fucker / transmascdruid / anarchoenby77 / darktwistedpussy / Druid of Endicot'

Apr 30, 2018

35-year-old Stephanie Cianfriglia has yet to figure out how not to humiliate herself in the decade-plus she's been on social media. Her best-known incident was when she cursed a Twitter user's womb to be barren, which earned her the nickname "womb wizard" across social media platforms. She's also notorious for grooming children on DeviantArt, attempting suicide by drinking hand sanitizer, and fucking ghosts. She now goes by Yarrow Brown, since she was born Ayla Brown. Her biological mother surrendered her for adoption to the unsuspecting Cianfriglias during her toddler...

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