Let's see...
1) If I'm going to be playing as a leader, have my character FEEL like a leader, not some dopey college undergrad who, like, uh... gets all confused, and uh, like, right?
2) Give me a reason to give a shit. 1st trilogy: Oh shit, it's us versus some cosmic horror beyond the galaxy whose sheer presence is nearly overwhelming (at least for the first 2 games and the first... 1/3 or part 3)! Andromeda: Stone-face monkey man is bad, wants to destroy things... for REASONS.
3) Bring back the Renegade/Paragon aspects.
4) IF THIS IS A FLAGSHIP TITLE OF YOUR STUDIO, FUCKING TREAT IT LIKE ONE.
5) Give me a supporting cast of characters whose backstories are actually interesting and diverse BEYOND about whether or not my character can put their dick into them. And as stated with point one, don't have them all talk like naive 18-year olds.
6) I understand big games cost money to make, blah blah blah. So make sure whatever you put on the (sadly) obligatory season pass is actually worth the money. And fuck right off if you decide to add any microtransactions.