- Joined
- Dec 30, 2018
What happens if Ebola-san and Corona-chan gets married and have a child?
Wuhan Coronavirus: Megathread - Got too big
- Thread starter JosephStalin
- Start date
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- Joined
- Jan 22, 2018
- Joined
- Mar 15, 2019
Stop shipping and gender bending virii unless you want to summon something like Captain Trips, for this is how you get Captain Trips.
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- Joined
- Jun 24, 2019
Rate me late but isn't Covid losing traction in Italy and becoming less lethal?
Somewhat related, these protests and riots will be a real test if things really are getting better because that's a super spreader. If by two weeks no one gets sick from this, we should be in the clear to go back to somewhat normalcy.
Somewhat related, these protests and riots will be a real test if things really are getting better because that's a super spreader. If by two weeks no one gets sick from this, we should be in the clear to go back to somewhat normalcy.
- Joined
- Dec 30, 2018
Yes, now they're mostly opened again and whining about money.
Sekirodiealot
kiwifarms.net
- Joined
- Dec 18, 2019
Knowing the media, they'll try to inflate the numbers
- Joined
- Mar 15, 2019
My own read on situation is that it is not becoming less lethal, but people, who were going to die to it have mostly died. This is why I stopped going to supermarket in my full face P3 gas mask, stopped autistic decon of groceries and deliveries, and started showing up in the office in person a month ago. Not ashamed for my over the top precautions in the beginning - better safe than sorry, but also comfortable with dropping them, when they are proven unnecessary.
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- May 13, 2020
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- Jul 17, 2019
- Joined
- Jan 6, 2019
Thank you! What’s interesting is that this backs up what we were saying a while back - that perhaps serious epidemics of history were events like COVID - viruses that spilled over and over time have mellowed. The virus discussed in that paper, HCoV-OC43 is one of the common cold variants. It’s not beyond belief to think that in time, SARS CoV2 will also mellow and become a seasonal cold. I know you have to be careful with assigning causes to past events, but it’s fun, and interesting, to speculate.
It’s also possible of course that the 1890 outbreak was flu, or that it was flu and simultaneously a corona spillover - we won’t ever know. The ebb and flow of the endless evolutionary arms race is the point. Sometimes we are ahead, and sometimes the viruses are.
- Joined
- Jun 11, 2018
I believe someone may have already mentioned Michigan's Stay Home/Safe is ending with a lot few restrictions by the end of next week. So, this will probably be my last update here.
My city: Three new cases in the last week with no deaths,
Workplace city: Neither new cases nor deaths for the second straight week.
County-wide, there were 176 new cases, 42 deaths, 344 people who went at least 30 days past their symptoms, and 210 less people who neither died nor qualified as recovered.
Even if I'm not quite gung ho about going out on a regular basis, I'll be happy to have less restrictions in place finally.
My city: Three new cases in the last week with no deaths,
Workplace city: Neither new cases nor deaths for the second straight week.
County-wide, there were 176 new cases, 42 deaths, 344 people who went at least 30 days past their symptoms, and 210 less people who neither died nor qualified as recovered.
Even if I'm not quite gung ho about going out on a regular basis, I'll be happy to have less restrictions in place finally.
- Joined
- Mar 1, 2020
I've gathered some more intel and I think I've found out why COVID-19 disproportionately kills black people. It has to do with differences in endothelial function. Black people have substantially higher rates of high blood pressure and diabetes. It has to do with diet, genetics, and skin pigmentation. If someone is vitamin D deficient (that is, if they have less sun exposure because they're sedentary and always have a roof over their heads; black people carry the roof with them, it's called melanin), they'll have more NADPH oxidase activity and more oxidative stress. Vitamin D restrains and regulates the production of reactive oxygen species.
One such example of ROS is superoxide, produced by the action of NADPH oxidase. Superoxide reacts with nitric oxide to form peroxynitrite, a powerful oxidizing and nitrating agent that's cytotoxic. In the process, nitric oxide is depleted. Black people naturally produce more superoxide and peroxynitrite (i.e. they're always in a redox state).
To make matters worse, COVID-19 alters one's lipid and metabolite profile, reducing carbamoyl phosphate levels.
Normally, carbamoyl phosphate reacts with ornithine to form citrulline, and then it is converted to arginine, and finally, it's converted to nitric oxide.
Nitric oxide is a vasodilator and it's critical to endothelial health. If it's being converted into peroxynitrite by excess superoxide, and if carbamoyl phosphate is cut off, then nitric oxide is inevitably depleted. And this is what we're seeing in COVID-19. Loss of NO bioavailability.
www.medpagetoday.com
This is concerning, because nitric oxide does more than support endothelial health. It also has a possible direct antiviral effect against coronaviruses. We know it can block the Spike protein and slow the replication of SARS-CoV. Due to their similarities, it may also be able to slow the replication of SARS-CoV-2.
pubmed.ncbi.nlm.nih.gov
In summary, black people are already teetering towards endothelial dysfunction just by default, all the time. COVID-19 tips the balance even further, with lethal consequences. This is most likely why COVID-19 disproportionately kills blacks.
I think the key to saving African-American patients sick with COVID-19 (as well as many of the other more severe cases) is to restore NO bioavailability. Nicotine and Vitamin D can regulate or even inhibit excessive NADPH oxidase activity. Citrulline, arginine, and cysteine supplementation can significantly increase nitric oxide.
To recap, SARS-CoV-2 can:
Medicine doesn't give a damn about political correctness. People need therapy that's tailored to their genetics. Deluding ourselves into thinking that we're all physically identical is going to hurt and kill innocent people.
One such example of ROS is superoxide, produced by the action of NADPH oxidase. Superoxide reacts with nitric oxide to form peroxynitrite, a powerful oxidizing and nitrating agent that's cytotoxic. In the process, nitric oxide is depleted. Black people naturally produce more superoxide and peroxynitrite (i.e. they're always in a redox state).
To make matters worse, COVID-19 alters one's lipid and metabolite profile, reducing carbamoyl phosphate levels.
Normally, carbamoyl phosphate reacts with ornithine to form citrulline, and then it is converted to arginine, and finally, it's converted to nitric oxide.
Nitric oxide is a vasodilator and it's critical to endothelial health. If it's being converted into peroxynitrite by excess superoxide, and if carbamoyl phosphate is cut off, then nitric oxide is inevitably depleted. And this is what we're seeing in COVID-19. Loss of NO bioavailability.
A Possible Explanation for the COVID-19 Racial Disparity
And a possible solution
This is concerning, because nitric oxide does more than support endothelial health. It also has a possible direct antiviral effect against coronaviruses. We know it can block the Spike protein and slow the replication of SARS-CoV. Due to their similarities, it may also be able to slow the replication of SARS-CoV-2.
Dual effect of nitric oxide on SARS-CoV replication: viral RNA production and palmitoylation of the S protein are affected - PubMed
Nitric oxide is an important molecule playing a key role in a broad range of biological process such as neurotransmission, vasodilatation and immune responses. While the anti-microbiological properties of nitric oxide-derived reactive nitrogen intermediates (RNI) such as peroxynitrite, are...
pubmed.ncbi.nlm.nih.gov
In summary, black people are already teetering towards endothelial dysfunction just by default, all the time. COVID-19 tips the balance even further, with lethal consequences. This is most likely why COVID-19 disproportionately kills blacks.
I think the key to saving African-American patients sick with COVID-19 (as well as many of the other more severe cases) is to restore NO bioavailability. Nicotine and Vitamin D can regulate or even inhibit excessive NADPH oxidase activity. Citrulline, arginine, and cysteine supplementation can significantly increase nitric oxide.
To recap, SARS-CoV-2 can:
- Get into the brain and cause encephalitis and new-onset seizure, with detectable virions in the cerebrospinal fluid.
- Cause temporary loss of sense of smell and/or taste.
- Infect the lungs and cause bilateral viral pneumonia, pulmonary fibrosis, and even full atelectasis of both lungs.
- Cause hypoxemic insult to all of the vital organs.
- Infect the lining of blood vessels and cause endotheliitis and even a Kawasaki disease-like syndrome in children.
- Cause coagulopathy, viremia, and sepsis, with clotting severe enough to cause heart attacks, strokes, or even PE. Patients have thrombocytopenia because their platelets are used up, and their D-dimer levels are often well above 3000 ng/ml, and sometimes as high as 20,000+ ng/ml.
- Infect the heart muscle and cause heart injury. Noticeable in elevated troponin levels.
- Infect the liver and/or bile duct, causing abnormal liver enzyme levels.
- Infect the kidneys and cause acute kidney injury requiring dialysis.
- Infect the GI tract and cause abdominal pain and diarrhea.
- Infect the testes and cause testicular pain, hormone imbalance, and possible male sterility.
- Destroy T lymphocytes and cause lymphopenia.
- Inhibit interferon production.
- Imbalance the renin-angiotensin-aldosterone system and cause hypokalemia, oxidative stress, and severe inflammation, injuring tissues with cytokine storms and destabilizing atherosclerotic plaques.
- Alter one's lipid and metabolic profile (in the case of SARS, this could even become permanent).
- Pneumonia
- Seizure
- Stroke
- Heart attack
- Pulmonary embolism
- Idiopathic pulmonary fibrosis
- Kidney failure
- Autoimmune disease
- Vasodilation and bronchodilation for the lungs, as well as a nasal cannula supplying oxygen or intubation and mechanical ventilation. Nitric oxide inhalation may be very helpful.
- Vitamin D, nicotine, citrulline, arginine, and/or cysteine to try and increase NO levels.
- Anti-seizure medication, if necessary, like levetiracetam.
- Anticoagulation therapy. Lots of heparin.
- IV immunoglobulin for endotheliitis/capillary leak.
- Dialysis, if the kidneys are having a hard time.
- Lopinavir/ritonavir, camostat, and/or interferon to cut down on viral replication.
- Monoclonal antibodies against each specific inflammatory cytokine, like tocilizumab.
Medicine doesn't give a damn about political correctness. People need therapy that's tailored to their genetics. Deluding ourselves into thinking that we're all physically identical is going to hurt and kill innocent people.
- Joined
- Dec 17, 2019
Michigan, USA
Governor Gretchen Whitmer, (D) was questioned by a U.S. House subcommittee about her response to the Corona outbreak, along with two other governors.
(archive)
Some highlights:
OFFICIAL DEATH TOLL
The Michigan Department of Health and Human Services reviews deaths and adds overlooked cases to the count three days a week: Tuesday, Thursday, and Saturday (usually). Recovery counts are updated on Saturdays.
11 deaths were added today.
Detroit Metro (pop. 3,860,000 total; 1,796/sq. mi.; 694/sq km):*
35,600 confirmed / 4,292 dead
35,560 confirmed / 4,269 dead yesterday
(i.e. 23 new deaths, up 15 from this day last week)
Normal Detroit Metro Death Rate: 104 per day.**
Other Michigan (6,120,000; 65/sq. mi.; 25/sq km):
22,131 confirmed / 1,261 dead
21,972 confirmed / 1,247 dead yesterday
(i.e. 14 new deaths, down 4 from this day last week)
Normal not-Detroit Death Rate: 167 per day**
All Michigan (9,990,000; 103/sq. mi.; 40/sq km):
57,731 confirmed / 5,553 dead
57,532 confirmed / 5,516 dead yesterday
(i.e. 37 new deaths, up 11 from this day last week, same as last week with no adjustments)
Normal Michigan Death Rate: 271 per day.**
Death toll doubled since: April 21.
We were locked down from: March 24 (untilApril 30? May 21 June 1),
Masks have been mandatory in stores since: April 27 (until April 30?).
Detroit Metro Daily Deaths Last Seven Days:
38*** / 17*** / 25 / 19*** / 23 / 10 / 13***= 187***
State Government site, daily - today's archive;
State Gov site, total, includes breakdowns by sex, age, race and ethnicity - today's archive.
*Here defined as the City of Detroit, and Macomb, Oakland, and Wayne Counties, minus state and federal prisoners, who are not counted towards any county's cases, but are kept in categories of their own.
** As of 2018.
*** [14,] 17, 37, and 11 statewide deaths, respectively, were added on these days upon State review. I don't know how many were in Detroit.
[Edit: forgot about the first adjustment.]
One Ann Arbor man allegedly killed by his roommate in a Corona-related dispute (archive). The suspect has been released from custody while the investigation continues (archive).
One Flint security guard allegedly murdered for telling a woman that her daughter needed to wear a mask in a dollar store. Multiple suspects are in custody (archive, A&N thread).
Governor Gretchen Whitmer, (D) was questioned by a U.S. House subcommittee about her response to the Corona outbreak, along with two other governors.
(archive)
Some highlights:
Detroit Free Press said:
OFFICIAL DEATH TOLL
The Michigan Department of Health and Human Services reviews deaths and adds overlooked cases to the count three days a week: Tuesday, Thursday, and Saturday (usually). Recovery counts are updated on Saturdays.
11 deaths were added today.
MDHHS said:
Detroit Metro (pop. 3,860,000 total; 1,796/sq. mi.; 694/sq km):*
35,600 confirmed / 4,292 dead
35,560 confirmed / 4,269 dead yesterday
(i.e. 23 new deaths, up 15 from this day last week)
Normal Detroit Metro Death Rate: 104 per day.**
Other Michigan (6,120,000; 65/sq. mi.; 25/sq km):
22,131 confirmed / 1,261 dead
21,972 confirmed / 1,247 dead yesterday
(i.e. 14 new deaths, down 4 from this day last week)
Normal not-Detroit Death Rate: 167 per day**
All Michigan (9,990,000; 103/sq. mi.; 40/sq km):
57,731 confirmed / 5,553 dead
57,532 confirmed / 5,516 dead yesterday
(i.e. 37 new deaths, up 11 from this day last week, same as last week with no adjustments)
Normal Michigan Death Rate: 271 per day.**
Death toll doubled since: April 21.
We were locked down from: March 24 (until
Masks have been mandatory in stores since: April 27 (until April 30?).
Detroit Metro Daily Deaths Last Seven Days:
38*** / 17*** / 25 / 19*** / 23 / 10 / 13***= 187***
State Government site, daily - today's archive;
State Gov site, total, includes breakdowns by sex, age, race and ethnicity - today's archive.
*Here defined as the City of Detroit, and Macomb, Oakland, and Wayne Counties, minus state and federal prisoners, who are not counted towards any county's cases, but are kept in categories of their own.
** As of 2018.
*** [14,] 17, 37, and 11 statewide deaths, respectively, were added on these days upon State review. I don't know how many were in Detroit.
[Edit: forgot about the first adjustment.]
One Ann Arbor man allegedly killed by his roommate in a Corona-related dispute (archive). The suspect has been released from custody while the investigation continues (archive).
One Flint security guard allegedly murdered for telling a woman that her daughter needed to wear a mask in a dollar store. Multiple suspects are in custody (archive, A&N thread).
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- Joined
- Oct 9, 2019
Alright. Spain news. Mostly good news. Cadiz is actually the second most province for job creation in spain this week, first most is seville. So good news all around for andalusia. Specially because this has been a REALLY good week for job creation overall. Politically things are moving forward at decent rates. Deescalation is still going, we might enter phase 3 this monday, we'll see. (Phase 4 is just total normalcy. Phase 3 is only restrictions are on massified events like football or concerts.) Overall. Really nice. Cadiz has fixed 15k jobs from the ERTEs and recovered another 3k on top. That is incredible. And the stocks are still going green for pretty much all of europe. Just really good.
On the circus side of things, Ayuso is back. After being told to lay off the fucking trash food already by the judges because we literally got laws regulating what is considered acceptable school food. She has just thrown her hands in the air and refused to serve any food at all. Which has gotten her sued again, but she said until the judge forces her she ain't doing shit. So I guess next week or so she'll get fined for being a cunt. Thankfuly the NGOs are already on it. But taking into account this is exactly what she accused the left of doing, and the left has kept their word and served appropiate food all throughout the pandemic, well, you can imagine the meme that are coming out of it. Overall. 5/5 would kek again. I mean seriously just making some Tapas instead isn't that fucking hard. We have so many restaurants that could help on that for really cheap prices. She's just retarded, or corrupt, or both. If fucking Kichy can figure it out everyone can.
And on other news. USA puts an import charge on french products and threatens to fo the same to spain, the UK, the EU as a whole, 9 other countries, and the motherfucking UN, over the bloody internet taxes. What the fuck is wrong with whoever took that decision I don't know but while threatening spain could work, threatening that many countries and the fucking EU and UN of all organizations is a very easy way to get told to shove it. Specially with how many imports you're gonna need just to fix those riots and the china ban already assfucking your economy. So... I guess we'll see if Trump can renationalize that supply chain fast enough. 'Cause if not that printer's gonna go full eurobeat until Venezuela wonders what the fuck was that inflation rate. I know for a fact spain ain't laying that tax off. At this point not having internet taxes is just asking for submerged economy ahoi. And we already got a large enough issue with that shit. It'd be too easy to commit tax fraud without the internet tax to fuck over all the cunts moving online just to dodge the state.
On coronachan news. Basically no news. Cadiz PROVINCE recorded 5 infected today, 0 yesterday. So yeah... Corona's fucking gone from here. Even the deescalation spike couldn't save her. Our waifu is dying.
On the circus side of things, Ayuso is back. After being told to lay off the fucking trash food already by the judges because we literally got laws regulating what is considered acceptable school food. She has just thrown her hands in the air and refused to serve any food at all. Which has gotten her sued again, but she said until the judge forces her she ain't doing shit. So I guess next week or so she'll get fined for being a cunt. Thankfuly the NGOs are already on it. But taking into account this is exactly what she accused the left of doing, and the left has kept their word and served appropiate food all throughout the pandemic, well, you can imagine the meme that are coming out of it. Overall. 5/5 would kek again. I mean seriously just making some Tapas instead isn't that fucking hard. We have so many restaurants that could help on that for really cheap prices. She's just retarded, or corrupt, or both. If fucking Kichy can figure it out everyone can.
And on other news. USA puts an import charge on french products and threatens to fo the same to spain, the UK, the EU as a whole, 9 other countries, and the motherfucking UN, over the bloody internet taxes. What the fuck is wrong with whoever took that decision I don't know but while threatening spain could work, threatening that many countries and the fucking EU and UN of all organizations is a very easy way to get told to shove it. Specially with how many imports you're gonna need just to fix those riots and the china ban already assfucking your economy. So... I guess we'll see if Trump can renationalize that supply chain fast enough. 'Cause if not that printer's gonna go full eurobeat until Venezuela wonders what the fuck was that inflation rate. I know for a fact spain ain't laying that tax off. At this point not having internet taxes is just asking for submerged economy ahoi. And we already got a large enough issue with that shit. It'd be too easy to commit tax fraud without the internet tax to fuck over all the cunts moving online just to dodge the state.
On coronachan news. Basically no news. Cadiz PROVINCE recorded 5 infected today, 0 yesterday. So yeah... Corona's fucking gone from here. Even the deescalation spike couldn't save her. Our waifu is dying.
- Joined
- Jan 14, 2018
If this is your last update, thanks much for all your contributions. Plenty of good info.
Here's an interesting Reason article. Some very good points made.
- Joined
- Mar 1, 2020
New cases are down across the board in much of the West. A good sign. However, there have been significant upticks in new cases in India, Brazil, Peru, Chile, Pakistan, and Qatar. Iran has also experienced a resurgence.
Europe is bringing it under control, as you say, but the Global South ain't looking so hot.
Coronavirus: Brazil now fourth-highest nation in Covid-19 deaths
Brazil records almost 1,000 deaths in a day, taking its overall number of fatalities past France.
www.bbc.com
If this is your last update, thanks much for all your contributions. Plenty of good info.
Here's an interesting Reason article. Some very good points made.
Widespread unemployment and a massive mental health crisis. Yep, there's no doubt about it. The lockdowns helped fuel the unrest.
Really, they did the whole thing wrong. Early screening and contact tracing would have allowed them to quarantine the sick instead of quarantining the healthy.
- Joined
- Sep 10, 2019
One week ago: Stay home think about Grandma
Today: Fuck your Grandma, we burning down this pharmacy!
Today: Fuck your Grandma, we burning down this pharmacy!
ditto
kiwifarms.net
- Joined
- Aug 17, 2019
Cubans did quarantine HIV patients in camps so good that people deliberately contracted it to get it.
The only person to suggest it in the USA was controlled opposition Lyndon LaRouche.
- Joined
- Jun 11, 2018
I knew there was one last point I wanted to bring up. I find it ironic that in the same states where people have been threatened with citations, fines, or even misdemeanor charges (i.e. a criminal record) for being out of the house unnecessarily while COVID-19 is an ongoing concern are being allowed to violate those same restrictions with impunity when they're out protesting or causing mayhem the past few days.
I also agree with whomever posted here or in the riot thread that we'll learn a lot more about COVID-19 in the next two weeks. If cases don't spike from protestors going out without masks and social distancing, it's going to be very difficult to sell independent-minded people on the claims that a second wave is inevitable the instant people start doing too many things out in public without precautions.
Also, I agree with the article that @JosephStalin posted that people largely confined to home for nearly three months with no outlet for their pent-up energies probably hit the boiling point this weekend. I believe most people are eager to partake in any sort of activity as soon as they're allowed to do so. Unfortunately, this isn't exactly the kind of activity anyone anticipated or probably wanted to see take place.
Cat Menagerie
kiwifarms.net
- Joined
- Nov 2, 2018
A Happenings crossover.
www.koco.com
archive.li
Whoopsie.
OSU LB Amen Ogbongbemiga tests positive for COVID-19 after attending Tulsa rally
Oklahoma State linebacker Amen Ogbongbemiga announced on social media that he has tested positive for COVID-19 after attending a protest in Tulsa.
www.koco.com
OSU LB Amen Ogbongbemiga tests positive for COVID-19 after attending …
archived 3 Jun 2020 02:06:54 UTC
Whoopsie.
- Status