Having seen this pattern among reviewers and "geek culture" so many times I feel the need to list some bulleted hypothesis as to why these people slip into insanity in the same ways. Tell me if any of this gels.
-Working from home. Staring at a screen daily, waiting for numbers to go up with very little feedback why a video you made is or is not getting enough views knowing that your livelihood could go away very fast if you can't figure it out is incredibly stressful. It seems even when making over 10,000 a month, the constant stress of uncertainty eats away at these people.
-Bad relationship. Many are familiar with Jimbo's love life. Being tied to a tumblrina that got big by eating tumblrinas that cheats on zem and gets off humiliating zem in public would drive anyone to insanity. Coupled with the unwillingness of most modern men to make peace with the idea of being alone places them in the same psychological situation as a captive, caged, animal. Miserable, but so institutionalized that they fear what's outside slightly more than being trapped.
-Career entrapment. Similar to the above and assuming truth in Josh's speculation about Jimbo's love of videogames long since dying, zey feel trapped in an unfulfilling job. While it would be possible for many to quit their current work and look for greener pastures, the public nature of the work renders finding another job difficult, though not impossible. However, the cage, while hated is also made of gold. Zey lack the courage to leave and subconciously resent themselves for their cowardice.
The overall theme is being trapped. Trapped at home, in a shit relationship, and in a job that is agony to perform. Unwilling to brave the outside, they instead try to change themselves in a vain hope for contentment. Of course, fundementally changing your outlook, drive, or temperament is difficult and a caged animal is, if nothing else, lazy. So instead, superficial changes are made.