COVID-19 is not what people think it is. It really isn't. If people listen to the way the media has presented this virus, they are told that it's a respiratory disease, that it's a pneumonia. While it's accurate to say that it causes a form of pneumonia and acute lung injury, what SARS-CoV-2 actually does is insidious. It attacks the lining of people's blood vessels and causes them to become edematous and leak into the lungs and other vital organs. People who die of COVID-19 do not die of pneumonia. They die of sepsis, heart failure, and disseminated intravascular coagulation brought on by vicious coagulopathy. This is why COVID-19 seems like an "everything-virus" that can injure every organ. It's because the blood vessels supply blood to every organ, and a virus that injures the blood vessels injures the organs, too.
But that's not all it does. COVID-19 also triggers hypoxemia by attacking the lungs, starving the brain and other vital organs of oxygen. It also triggers severe inflammation in each organ that it touches. And, on top of all of that, it causes extreme oxidative stress that leads to lipid peroxidation, ferroptosis, and injury to the mitochondria and reduction in their ability to generate energy for cells.
SARS-CoV-2 pulls a very strange sleight-of-hand with its host-virus interactions. Its proteins disable the body's own antioxidant enzymes, directly activate inflammatory pathways, destroy ACE2 receptors needed to inactivate bradykinin, and also act as calcium ion channels.
What groups of people are most strongly affected by COVID-19? Fat people and black people. What groups of people have metabolic syndrome and a reduced ability to deal with oxidative stress in their vascular endothelium? Fat people and black people. Let me explain.
As I've said before, inside our blood vessels is an enzyme called nitric oxide synthase that makes nitric oxide. Nitric oxide is a tiny signaling molecule that has many uses in the body, because it rapidly diffuses through normally impermeable cell membranes. Nitric oxide is also found in various other places, like cigarette smoke. Notice how smokers are less likely to develop severe COVID-19?
Nitric oxide is actually antiviral against SARS-CoV. It prevents the palmitoylation of the Spike protein of SARS-CoV, and research dating back years has shown this. Palmitoylation is the attachment of a fatty acid to a protein. In the case of SARS-CoV-2 and its spike, this makes it more infectious and makes it replicate faster.
Why does SARS-CoV-2 induce oxidative stress in the host by triggering intracellular calcium release and a bradykinin storm? Simple. It wants to destroy the nitric oxide in your body so it can replicate faster. Here's how that happens. When you have oxidative stress in your body, you have a lot of a free radical called superoxide floating around. This is the O2 anion referred to with the notation O2-. It's just O2, but it's missing an electron. It wants to strip that electron off of surrounding substances, like fats (like your cell membranes, cholesterol, whatever) in order to replace it. Free radicals are molecules that are "unhappy" because they're missing an electron, and this makes them prone to react to things around them in a process very similar to rust, or fire. Free radicals "rust" things in your body. That's what people mean when they say having an "antioxidant diet can help you live longer". What they're actually saying is you should eat things that act as sacrificial molecules to donate electrons to these free radicals so they don't strip electrons off of your cells, your DNA, whatever. Anyway, oxidation-reduction reactions in the body are vital for just about everything, including, uhh,
breathing, so you can't live without them. But, I digress.
When superoxide comes in contact with nitric oxide, it forms peroxynitrite by an irreversible chemical reaction that destroys both the superoxide and the nitric oxide. Peroxynitrite is
not antiviral against SARS-CoV-2's spike. What it does do is contribute to nitrosative stress.
Superoxide also has other downstream radicals, like hydrogen peroxide, hypochlorous acid, et cetera, and neutrophils dump out enzymes that make tons of these to try and destroy infections. If you have enough hypochlorous acid circulating around, it will actually destroy free heme and injure macrophages and promote the release of iron into the bloodstream. Unliganded free iron is highly reactive (just like it is outside the body, where it rusts readily), and when it reacts with hydrogen peroxide and superoxide, it makes hydroxyl radicals that are so reactive, they oxidize your lipid membranes within nanoseconds, causing irreversible damage.
This is why severe COVID-19 patients have the hallmarks of ferroptosis, or iron-mediated cell death caused by oxidative stress.
Since the outbreak of the new coronavirus in 2019 (SARS-CoV-2), many studies have been performed to better understand the basic mechanisms and clinical features of the disease. However, uncertainties of the underlying mechanisms of multiple organ involvement remain. A substantial proportion of...
www.nature.com
It's why they have antiphospholipid antibodies (something you usually see in fucking lupus), which form as a reaction to oxidatively damaged phospholipids.
A significant proportion of patients with COVID-19 — up to 52% by one metric — are at least transiently positive for potentially pathogenic antiphospholipid autoantibodies, according to a speaker at ACR Convergence.“Do COVID-19 patients get blood clots? Yes, they do,” Yu Zuo, MD, a physician...
www.healio.com
What does Vitamin D do? It regulates intracellular calcium levels and reduces superoxide production by regulating NADPH oxidase. It also activates a bunch of beneficial genetic activity through its receptor. This, in turn, means less superoxide. Which, in turn, means less nitric oxide destroyed by reaction with superoxide to form peroxynitrite, which means more nitric oxide in the blood vessels, which means slower replication of the virus due to the nitric oxide preventing the palmitoylation of the Spike.
African-Americans, as a group, have far less nitric oxide production in their blood vessels than other ethnic groups. This is a proven scientific fact. It's why they're more susceptible to metabolic syndrome (hypertension, diabetes, etc.). It's also very likely why COVID-19 is so much more aggressive in their bodies than in other groups.
There are a number of ways to tackle this problem therapeutically, actually, on top of Vitamin D. Apocynin (it's found in Kutki Powder), quercetin, resveratrol, dietary nitrate, N-acetylcysteine, glutathione supplementation, et cetera. So long as you can prevent the positive feedback loop of inflammation and oxidative stress in COVID-19, you can probably keep someone out of the ICU.
I'll tell you how it makes sense. It makes sense if the motherfuckers out there who are intentionally perpetuating this crisis are sick, anti-natalist Illuminati bastards who are using a manufactured crisis to usher in the New World Order.
My only intentions in all of this, all along, were to see if I could find out what the hell COVID-19 was, why it caused the symptoms that it did, and what could be done to treat it. Back in March/April, I thought they were going to lock things down for, at the most, a month, to see if they could arrest transmission completely and prevent the virus from becoming endemic. But they didn't. They allowed it to become endemic, while
also locking people down for months and months and months, to the point that their health and their livelihoods were jeopardized.
I have never seen such incompetence in my life. In fact,
active malice is a far more reasonable explanation for the policies that public officials have pursued. Stuffing COVID-19 positive people into nursing homes in New York was not an innocent little mistake. It was
murder. Andrew Cuomo has blood on his hands.