Well, I'm not going to pretend I know anything about business or what's profitable; these are just my observations as a former long-time RT fan. That said, I definitely think RT could benefit from trimming the fat and focusing in on a smaller handful of shows in order to produce better quality content, instead of spraying it everywhere and succeeding at nothing.
Most likely, I'd get rid of most of their animated series, as the majority of them are mediocre and/or have low viewership; X-Ray and Vav would be an exception, as it was quite aggressively mediocre, but also very popular. I'd also keep RWBY and RTAA for the profit margins, and RVB because killing it would cause the loss of most pre-2014 fans (as we're currently seeing in action). All other animated shows would require review to see if they're even worth keeping around, but I might be a little less quick to the draw with AH Animated, since it occupies a niche similar to RTAAs in the form of distilled videos set to Flash animation, which is pretty popular with most people.
Similarly, I'd gut most of the podcasts; some of them are dead on arrival due to lack of co-stars (i.e. any podcasts that featured Ryan or Adam primarily), while others are superfluous or just unpopular. I would keep the RT Podcast, Off-Topic, the Funhaus Podcast for any transplant fans, and MAYBE Always Open if it had enough viewership (but from the impression I get of it, that's not the case). The Patch is another unique case where, even though it was a bit superfluous, I actually think having a strictly gaming podcast was a good anchor for the subset of RT fans who came for games only; that's something they'd always find interesting to watch, regardless of its actual content. So I'd probably rebrand The Patch and/or pick a different co-star (someone like Geoff or Michael probably), but otherwise keep the format the same.
As for the other billion miscellaneous shows, I'd probably reduce it down to just the most notable ones - On the Spot and Million Dollars would have to stay, even though I hate them, and definitely Immersion, too. RT Shorts are something of a relic of the past, but old fans would flip out if they were stopped altogether, so I'd keep them as well. Conversely, the RT Life/RT Recap/"behind the scenes" videos feel a bit hokey nowadays, but I think younger fans like them, so I'd keep pretty much all of them. All the other ones that I can't even be assed to know the name of would have to be reviewed and probably removed.
As for AH, I actually think they did a pretty good job keeping their content strictly centered on gaming, so that would be another case of having to just look at the numbers and see what's the most popular and what's lagging behind. AH is probably RT's most consistent group in terms of bringing in profits, so I wouldn't bring down the hammer too hard on them, but they could certainly stand to cut out some of their less popular series that they keep pushing for whatever reason.