Wuhan Coronavirus: Megathread - Got too big

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Aqua Panda said:
The lab leak theory is gaining major traction. Gotta love how it was considered crackpot tier only a few weeks ago.

If it can be proven the geopolitical fallout will be next level.
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I wonder what's gonna happen if it is, would countries be able to sue for damages to their economies and the loss of life? I know that happens in war, but idk if it applies in this case since it's so unprecedented. I'd imagine if that were the case, China would have to pony up unless they wanna fight a war against the whole world.

Honestly the loss of face in having it confirmed would be worth it, I would be satisfied with the CCP looking like total morons in the world stage.
 
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Fauci straight-up committed perjury in front of Congress. It's time to lock his lying ass up.


Jamila said:
I dunno, I'm not a medfag, just an autist who likes to read about infectious diseases. Side effects tend to be worse if you've already had COVID, so I imagine for most people it's simply the body mounting an intense immune response. As for the more serious side effects, it looks like the issue is not about antibodies or immunity per se, but the spike protein causing cellular damage.

Here's the paper that claims to have solved why the adenovirus vector vaccines cause blood clots. TL;DR the spike protein.
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The Spike protein of SARS-CoV-2 is not inert. It's active pathogenic material. This is a protein that binds to ACE2 and triggers intracellular signaling while also rendering that ACE2 unavailable for its ordinary purpose of enzymatically cleaving Angiotensin II and inactivating bradykinin.




The proteins made by some of these vaccines, particularly the full-length proteins, are binding to ACE2 expressed on the surfaces of people's cells. It is behaving like a protein biologic ACE2-blocking drug while also triggering activity inside cells.

vaccines-09-00036-g002.jpg

It was found that the treatment of cultured primary human pulmonary artery smooth muscle cells (SMCs) or human pulmonary artery endothelial cells with the recombinant SARS-CoV-2 spike protein S1 subunit is sufficient to promote cell signaling without the rest of the viral components [21]. Furthermore, our analysis of the postmortem lung tissues of patients who died of COVID-19 has determined that these patients exhibited pulmonary vascular wall thickening, a hallmark of pulmonary arterial hypertension (PAH) [21]. Based on these results, we proposed that the SARS-CoV-2 spike protein (without the rest of the viral components) triggers cell signaling events that may promote pulmonary vascular remodeling and PAH as well as possibly other cardiovascular complications [21,22].

In our cell culture experiments, two recombinant SARS-CoV-2 spike proteins, both of which contain the RBD, were studied [21]. The full-length S1 subunit protein contains most of the S1 subunit (Val16–Gln690), while the RBD S1 subunit protein only contains the RBD region (Arg319–Phe541), as shown in Figure 1. Cultured primary human pulmonary artery SMCs and human pulmonary artery endothelial cells were treated with these proteins for 10 min. We found, using the phospho-specific MEK antibody, that the recombinant full-length S1 subunit of SARS-CoV-2 alone at a concentration as low as 130 pM activated MEK, the activator of extracellular signal-regulated kinase (ERK) and a well-known signal transduction mechanism for cell growth [23]. By contrast, such activation of cell signaling by the spike protein did not occur in rat pulmonary artery SMCs [21].

While ACE2 is now well known as a ‘receptor’ to which the SARS-CoV-2 spike protein binds on human host cells in order to facilitate the membrane fusion and gain viral entry, the usual physiological function of ACE2 is not to serve as a membrane receptor to transduce intracellular signals. ACE2 is a type I integral membrane protein that functions as a carboxypeptidase, cleaving angiotensin II to angiotensin (1–7) and regulating blood pressure [24,25] (Figure 2). However, ten years ago, Chen et al. [26] reported the intriguing findings showing that ACE2 acts as a membrane receptor for cell signal transduction in response to the spike protein of SARS-CoV (now also known as SARS-CoV-1, the virus that caused the SARS outbreak in 2002–2004) in the human lung alveolar epithelial cell line, A549. The spike protein of SARS-CoV-1 is 76–78% identical to that of SARS-CoV-2 [27]. In their study, it was shown that the binding of the full-length spike protein to ACE2 triggered the casein kinase II-dependent activation of activator protein-1 (AP-1) transcription factor and subsequent gene transcriptional events [26]. Their finding on SARS-CoV-1 [26] and ours on SARS-CoV-2 [21] indicate that the spike protein remarkably functionally converts ACE2 (that is normally a peptidase enzyme) into a membrane receptor for cell signaling that uses the spike protein as a ligand for its activation (Figure 2).
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For those who don't know what the hell a membrane-bound protein even is, this video certainly helps lay it all out:


Membrane-bound proteins are used for all kinds of shit. Ferrying materials in and out of cells like gateways, molecular signaling, you name it. ACE2 does not ordinarily behave as a signal transducer, or a molecular relay from the exterior of a cell to the interior. Normally, it just acts like a pair of molecular scissors, cutting specific hormones to alter their function. Spike binding to ACE2 actually causes it to trigger activity inside the cell, with unknown and possibly pathological implications. It also destroys the ACE2.

F1.large (1).jpg

When Spike binds to ACE2, it's irreversibly bound, creating the compound Spike-ACE2, which is both proteins attached end to end. The only way for your cells to get the ACE2 back is by taking that protein, junking it (cells have recycling centers for the express purpose of tagging and breaking down useless proteins and other junk), and then building new ones by feeding mRNA from the nucleus through the ribosomes, like any other protein. The newly-manufactured replacements travel to the cell surface and embed in the membrane. If fresh Spike proteins are continuously binding to even the newly-created ACE2, its ordinary functions will be suppressed and replaced with pathological ones.

What are the consequences? Well, look at the distribution of ACE2 proteins in cell lines in the human body.


Tissue expression of ACE2 - Summary - The Human Protein Atlas

Summary of ACE2 expression in human tissue. Membranous expression in proximal renal tubules, intestinal tract, seminal vesicle, epididymis, exocrine pancreas and gallbladder. Expressed in Sertoli and Leydig cells, and trophoblasts. Membranous expression in ciliated cells in nasal mucosa...
www.proteinatlas.org www.proteinatlas.org



It's all over the place. It's in vascular endothelial cells and pericytes, the lining of the GI tract, renal tubules, male and female reproductive tissues, the lungs, everywhere.

This is, of course, why COVID-19 causes blood clots, diarrhea, sepsis, and kidney failure on top of pneumonia. Anything with an ACE2 receptor can be infected by the whole SARS-CoV-2 virus. But the Spike, even without the rest of the virus, can also bind to ACE2 in those tissues, with unknown and possibly very harmful effects.

The vaccine is potentially quite dangerous.
 
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Good news on my end: my church's council voted unanimously to end all coof restrictions. No more social distancing, traditional communion at the altar, fellowship after church, the whole nine yards. I would have gone farther and banned masks altogether, but although they're not required (and haven't been for a couple weeks), they said "use your own judgment" on those. Pastor is still doing a separate communion after church for anyone worshiping remotely, though I dunno how many people are still coming in for that; I wouldn't be surprised if that ended eventually due to lack of participation. He even mentioned at church tonight that he's giving his blessing to remote worshipers to take communion at home if they so choose; theologically, it's a traditional Lutheran belief that you really don't need a pastor to bless the elements for you, so he's okay with it in these circumstances. Dunno why he didn't think about this a year ago, but oh well.

I'm noticing fewer people with masks on as I go out and about, and more stores are taking down their "masks required" signage. Some are replacing them with a "masks encouraged" sign, but others are just dropping them entirely. I no longer feel like I'm sticking out like a sore thumb, which was really fucking annoying when I was the only one acting normally. Things are just about back to normal again.

Thank God I don't live in a blue state.
 
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King Dead said:
Good news on my end: my church's council voted unanimously to end all coof restrictions. No more social distancing, traditional communion at the altar, fellowship after church, the whole nine yards. I would have gone farther and banned masks altogether, but although they're not required (and haven't been for a couple weeks), they said "use your own judgment" on those. Pastor is still doing a separate communion after church for anyone worshiping remotely, though I dunno how many people are still coming in for that; I wouldn't be surprised if that ended eventually due to lack of participation. He even mentioned at church tonight that he's giving his blessing to remote worshipers to take communion at home if they so choose; theologically, it's a traditional Lutheran belief that you really don't need a pastor to bless the elements for you, so he's okay with it in these circumstances. Dunno why he didn't think about this a year ago, but oh well.

I'm noticing fewer people with masks on as I go out and about, and more stores are taking down their "masks required" signage. Some are replacing them with a "masks encouraged" sign, but others are just dropping them entirely. I no longer feel like I'm sticking out like a sore thumb, which was really fucking annoying when I was the only one acting normally. Things are just about back to normal again.

Thank God I don't live in a blue state.
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There is a sense of community with taking communion, likely it had not occurred to him because it feels integral without being integral. Easy to have blindspots to possibilities in such a case.
 
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Incidence around here is in freefall, and the gym is finally open even for those without letters of indulgence proving our purity.
Now it's the Branch Covidians crying about the numbers being fake and everyone being lied to, and how the lifting of restrictions is going to kill us all by autumn.
Well yeah, of course this will come back in autumn. No amount of permanent lockdown will prevent that, you absolute pillocks.
 
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Meriasek said:
Incidence around here is in freefall, and the gym is finally open even for those without letters of indulgence proving our purity.
Now it's the Branch Covidians crying about the numbers being fake and everyone being lied to, and how the lifting of restrictions is going to kill us all by autumn.
Well yeah, of course this will come back in autumn. No amount of permanent lockdown will prevent that, you absolute pillocks.
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It is fun watching the disease lose its power and the left see its window for absolute control narrow and narrow and narrow.
 
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What really pisses me off these days is that even when I just say that I'm slightly miffed that I don't really see a good reason to get vaccinated personally, I still get treated like some sort of anti-vaxxer even when I make it clear that I will get vaccinated at some point. I'm just not happy with the explanations given, but for convenience I will get the jab unless super hardcore long term effects appear to the public before I'm on the list.
But no, compliance is not enough. You have to want it. Remember in 1984 when O'Brian is torturing Winston, and Winston tries to say whatever O'Brian wants to hear, but it doesn't work because superficial compliance isn't good enough?
That's what ordinary people have turned into.
 
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Back in the early days of the outbreak, I remember reading there was a holding facility for lab specimen animals.
Literally down the road from the Wuhan wet market.

I don't think it was the CDC building (which is about a half mile away), but closer.

One of the conspiracy theories suspected some of the animals (bats/pangolins) were sneaked out of the back door into the market.

Does anyone have any information about the animal holding facility
 
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Ayyy lmao our dear leaders are about to extend the epidemic situation over the summer, enabling all their emergency laws and powers. Makes sense, a lot of this shit is blatantly unconstitutional and will lead to massive problems once the epidemic is declared over, so... It won't be.
Time to post a bunch of surprised Kirks and Pikachus.

/edit:
No seriously. The current situation is officially declared until end of June. If they extend it another three months it'll be October and BOOM tis the season again.
 
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Meanwhile in Bongistan: NHS is in the final stages of move to a new huge database pooling records of 55 million patients and making it available to academic and third parties. [I wonder which these will be, considering they can pull pretty much any data they want, including yes, you guessed it- innoculation records]. :mad: Sky is the limit for all vaccine covidian shysters now!

Fuckers are pasing it under the radar, there is a bit of fuss from the privacy rights campaigners, but the general public is not even aware, because "The plan to create a new data set was announced by Matt Hancock, health secretary, in early April and publicised mainly on blogs on the NHS Digital website, and through flyers at GP surgeries, said NHS Digital," So, they can send me a few letters and 3 texts a week for about a month now to pester me about taking the vaccine, but they could not mount a public information campaign about this? I mean I know they take people for total imbeciles (may not be wrong there too, I admit), but this is just rich. Especially when you consider the cited quote ends in " the plans had been in the works for three years."

All bongistani farmers- if you want to opt out you need to print out the form from the NHS website and take it to your GP. before 23rd of June ... yep, on paper...yep, in person. Yep, to the same GP who did not want to see you for last 14 months and probably still will not let you in to hand in this paper. Slide it through the letterbox? "We never received anything, don't know what you're talking about"... Because millions of coins sunk into various NHS bozos pockets could not fund a piddly online submission/ opt out form [yes, I know they do it to create another obstacle for you and force a situation when people are unable to submit it, the hostile sociomanipulative cunts they are, but I need to went! (:_(]

Last but not least I'm sure it's a total coincidence they called this new service GPDPR, because it will not make an impression on an average Joe with 6 second attention span that it's just something to do with the GDPR so I should not think too much about it, it was made for my benefit, wasn't it?

[for non-bongs and non-eurofags: GDPR stands for General Data Protecting Regulation introduced in 2018 in all of the EU countries, setting legal framework for how your data is handled and was always advertised as something to protect you as a data owner from predatory companies/offices misusing your sensitive info]


Anyhoo, have a look for yourself :
Archive of the FT article, original is paywalled so no point in linking it here I guess
Some security points https://www.theregister.com/2021/05/24/nhs_digital_gp_data_store/ and its archive
 
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Meriasek said:
What really pisses me off these days is that even when I just say that I'm slightly miffed that I don't really see a good reason to get vaccinated personally, I still get treated like some sort of anti-vaxxer even when I make it clear that I will get vaccinated at some point. I'm just not happy with the explanations given, but for convenience I will get the jab unless super hardcore long term effects appear to the public before I'm on the list.
But no, compliance is not enough. You have to want it. Remember in 1984 when O'Brian is torturing Winston, and Winston tries to say whatever O'Brian wants to hear, but it doesn't work because superficial compliance isn't good enough?
That's what ordinary people have turned into.
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It's surprisingly easy to mentally condition the masses to think a certain way if you scare them enough. They don't get called "sheep" for nothing *tips fedora*.
 
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