Here's my tinfoil hat theory that's fueled by too little sleep and too much coffee: Isabella Janke is a self-hating troon.
It's clear she's a latent serial killer, because she's got at least two of the MacDonald triad going in bedwetting/pants shitting, and animal torture. If it's true that she's got fucked up hormones and testosterone like
@firion said, and wants to be a transmasc who doesn't transition, just dominate other women, there's probably a lot of chemicals bouncing around in her head all screwy. She also grew up on the internet, so it's likely she had no socialization outside of 4chan and discord. Seeing troons take over The Discourse might have broke something in her brain and she wanted to strike back. It could be why Isabella Janke, Louis Herz and the rest of the Texas Tech chess club harassed another trans kid (Roman Konopa) at the school to the point there was a Title IX investigation opened about it. When they had to abandon that gayop in late April, she doubled down on fucking with Chris in an attempt to really hit back at a well known and controversial troon. To really add some antennae to my hat, I'd love to know more about the Ariel Lassa death; was she part of the chess club, since the school seemingly wanted info from them back around the time it occurred? Was she someone that Isabella Janke tried to hook up with and then bullied to the point she committed suicide? Was she the Chris Chan practice run? I don't think we can put anything past the psycho bitch at this point.