No one would have followed quarantine. A big reason people are complaint now is because everyone can just watch netflix and listen to podcasts. Plus every dirtbag comedian would be posting on myspace how this was just a plot from the Rethuglicans to go full 1984. People were semi-scared of birdflu and anthrax, but after those 2 and some other bullshit i'm forgeting, people were tired of GOP nothing burgers. Also global knowledge was way worse back then so we wouldn't have seen those videos of Chinese people being welded into homes and other crazy shit except when it was shown on Fox News and we all know how much people trust them.
if your google-fu is good you can go back and watch old clips of how people were responding to the SARs and birdflu outbreaks. Jon Stewart, hunter s thompson, colin quinn, louis ck, patrice o'neal, howard stern, artie lange and Stephen Colbert told the Bush administration to go fuck themselves when the medical professionals were like "maybe this might be something to worry about" The Chinese would be as well liked as the Star Wars prequels, Muslims would suddenly be our best friends.
Also the baby boomers were only just entering the "danger zone" for the disease so people would have given less of a fuck because the Bush admin would be saying "we have to do this to protect the silent generation, who are mainly known for protesting civil rights and de-segregation because we should destroy our economy so literal klan members and nazis may live" which obviously wouldn't have helped the situation. the entertainment industry would be declaring war on him just because there was no paetreon, cameo, instagram, etc other ways for them to make money online shilling beauty products.
Everyone would be pro-"fuck grandma" in the 2000s. Especially with the rise of libertarian-ism back then. Even 2009 would be iffy. smart phones weren't ubiquitous, Netflix would be doubling in value every week, same with amazon. It probably would have worked because black people actually did what he said, but it would have soured people's reputation of him to 2016 levels in 2010.
also it probably would have fucked the entertainment industy way way harder than people think. celebrities would be uploading videos to youtube instead of to facebook and insta and snap but without the censorship and algorithm to help promote them they would have to compete against smosh and NigaHiga, and pewdiepie. it would really cause quite a few major celebs to sperg out. this was before it was known to not read comments or respond to trolls or other obvious shit. it would have been a shitload of fun for 4channers. plus most of youtube was parodies or snarking on celeb culture so people would have been absolute savages to these people, lots of "having a problem uploading your video? just delete system32"
We would have seen at least one film studio release straight to online. but there would have been a lot of problems. companies weren't focused on their online prescene back then, which is why netflix had almost every movie and tv show ever made.
online culture probably would be hugely different just because normies would have been forced online without the censorship and algorithms to keep them away from the regular, Encyclopedia Dramatica style internet.