What is the best gun to use against glowies?

Personally, I like long range sniping with a weapon that has high burst damage, as for example with a Gauss Rifle. This saves you from having to get close, and effectively sidesteps a Glowies two main powers - resurrecting minion swarms, and their Rad aura. If your stealth is high enough, you can take them down even on Survival before they figure out where you are.

If you need to fight them in CQB, I'd recommend bringing Power Armor (or Robes of Atom's Devoted, if you're feeling bold) and any high DPS gun with the Wounding prefix that you can get your hands on - maybe a shotgun or a minigun, let's say.
 
A regular one, just shoot them in the groin where they have level 3A armor at the most. Only applies to glowies that have gone off the reservation, for obvious Minecraft related reasons.
 
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