Wuhan Coronavirus: Megathread - Got too big

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Do you have any good sources on Bing Liu's oxidative stress disease hypothesis and research? Searching isn't turning up much, but this matches up with the musings of another doctor I follow who specializes in oxidative stress and I want to share Bing Liu's thoughts with him.
He never published a paper on COVID-19.

However, based on the sort of research he used to do:




And based on what we now know to be true about the virus:



It's easy to surmise what he would have published, if he had the opportunity.

Ferroptosis was actually a relatively new scientific discovery. The term was actually coined in 2012 by Brent Stockwell and Scott J. Dixon to describe a new type of cell death distinct from apoptosis, necroptosis, pyroptosis, et cetera. Basically, it's a form of cell death that occurs when lipid hydroperoxides accumulate due to the presence of lots and lots of unliganded iron.


The hallmark feature of ferroptosis is the iron-dependent accumulation of oxidatively damaged phospholipids (i.e., lipid peroxides). This change occurs when free radicals abstract electrons from a lipid molecule (typically affecting polyunsaturated fatty acids), thereby promoting their oxidation. The primary cellular mechanism of protection against ferroptosis is mediated by glutathione peroxidase 4 (GPX4), a glutathione-dependent hydroperoxidase that converts lipid peroxides into non-toxic lipid alcohols.[1] Recently, a second parallel protective pathway was independently discovered by two labs that involves the oxidoreductase FSP1 (also known as AIFM2).[9][10] Their findings indicate that FSP1 enzymatically reduces non-mitochondrial coenzyme Q10, thereby generating a potent lipophilic antioxidant to suppresses the propagation of lipid peroxides.[9][10] A similar mechanism for a cofactor moonlighting as a diffusable antioxidant was discovered in the same year for tetrahydrobiopterin (BH4), a product of the rate-limiting enzyme GCH1.[11]

Normally, the body encloses iron atoms in a protein called ferritin that acts as a cage, keeping the iron from reacting with anything it shouldn't. Unliganded "free" iron inside the body is reactive and toxic. It's just as reactive as iron sitting and rusting on a table.


Ferritin is a universal intracellular protein that stores iron and releases it in a controlled fashion. The protein is produced by almost all living organisms, including archaea, bacteria, algae, higher plants, and animals. It is the primary intracellular iron-storage protein in both prokaryotes and eukaryotes, keeping iron in a soluble and non-toxic form. In humans, it acts as a buffer against iron deficiency and iron overload.[3]

Ferritin is found in most tissues as a cytosolic protein, but small amounts are secreted into the serum where it functions as an iron carrier. Plasma ferritin is also an indirect marker of the total amount of iron stored in the body; hence, serum ferritin is used as a diagnostic test for iron-deficiency anemia.[4] Agregated ferritin transforms into toxic form of iron hemosiderin.[5]

Ferritin is a globular protein complex consisting of 24 protein subunits forming a hollow nanocage with multiple metal–protein interactions.[6] Ferritin that is not combined with iron is called apoferritin.

In COVID-19, this is generally happening due to the over-proliferation of NETs, or neutrophil extracellular traps:



Neutrophil extracellular traps also promote clotting:


There's also a lot of anti-PL antibodies in COVID-19:


The formation of antiphospholipid antibodies due to NETs and oxidation is actually a hallmark of friggin' Lupus.


The interest in the role of NETs in autoimmune diseases arose with the discovery of certain mechanisms that trigger NETosis by non-infectious stimuli, such as: immune complexes, autoantibodies, cytokines, cholesterol and monosodium urate (MSU) crystals [1]. Multiple studies have shown the implication of such mechanisms in NETs formation in chronic inflammatory processes, as seen in lung [9], systemic lupus erythematosus [10], antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis [11], rheumatoid arthritis [12], gouty arthritis [13,14], familiar Mediterranean fever [15], psoriasis [16] and autoimmune coagulation disorders [17,18].

Basically, it works like this:
  1. Neutrophils get really irritated by something, like viruses, bacteria, fungi, or an autoimmune reaction.
  2. Neutrophils start suicidally hurling their guts everywhere, which consist of their own nuclear DNA, histones, highly destructive myeloperoxidase enzymes, et cetera.
  3. Myeloperoxidase pumps out tons of hypochlorous acid by combining hydrogen peroxide and chlorine ions in the body.
  4. Excess hypochlorous acid oxidizes lipids and frees iron.
  5. Free iron makes even more radicals, such as producing hydroxyl radicals by the Haber-Weiss and Fenton reactions.
  6. Oxidized lipids are recognized as foreign objects.
  7. Immune system attacks oxidized lipids.


Oxidation-specific epitopes (OSE), present on oxidized LDL (OxLDL), apoptotic cells, cell debris and modified proteins in the vessel wall, accumulate in response to hypercholesterolemia, and generate potent pro-inflammatory, disease-specific antigens. They represent an important class of ‘danger associated molecular patterns’ (DAMPs), against which a concerted innate immune response is directed. OSE are recognized by innate ‘pattern recognition receptors’, such as scavenger receptors present on dendritic cells and monocyte/macrophages, as well as by innate proteins, such as IgM natural antibodies and soluble proteins, such as C-reactive protein and complement factor H. These innate immune responses provide a first line of defense against atherosclerosis-specific DAMPs, and engage adaptive immune responses, provided by T and B-2 cells, which provide a more specific and definitive response. Such immune responses are ordinarily directed to remove foreign pathogens, such as those found on microbial pathogens, but when persistent or maladaptive, lead to host damage. In this context, atherosclerosis can be considered as a systemic chronic inflammatory disease initiated by the accumulation of OSE type DAMPs and perpetuated by maladaptive response of the innate and adaptive immune system. Understanding this paradigm leads to new approaches to defining cardiovascular risk and suggests new modes of therapy. Therefore, OSE have become potential targets of diagnostic and therapeutic agents. Human and murine OSE-targeting antibodies have been developed and are now being used as biomarkers in human studies and experimentally in translational applications of non-invasive molecular imaging of oxidation-rich plaques and immunotherapeutics.

The thing about oxidized lipids is that they really cause a great deal of inflammation on their own, causing adjacent cells to activate transcription factors that generate inflammatory cytokines. They're called DAMPs for a reason.


Damage-associated molecular patterns (DAMPs)[1] are molecules within cells that are a component of the innate immune response released from damaged or dying cells due to trauma or an infection by a pathogen.[2] They are also known as danger-associated molecular patterns, danger signals, and alarmin because they serve as a warning sign for the organism to alert it of any damage or infection to its cells. DAMPs are endogenous danger signals that are discharged to the extracellular space in response to damage to the cell from trauma or pathogen.[3] Once a DAMP is released from the cell, it promotes a noninfectious inflammatory response by binding to a pattern-recognition receptor.[4] Inflammation is a key aspect of the innate immune response because it is used to help mitigate future damage to the organism by removing harmful invaders from the affected area and start the healing process.[5] As an example, the cytokine IL-1α is a DAMP that originates within the nucleus of the cell, which once released to the extracellular space, binds to the PRR IL-1R, which in turn initiates an inflammatory response to the trauma or pathogen that initiated the release of IL-1α.[3] In contrast to the noninfectious inflammatory response produced by DAMPs, pathogen-associated molecular patterns initiate and perpetuate the infectious pathogen-induced inflammatory response.[6] Many DAMPs are nuclear or cytosolic proteins with defined intracellular function that are released outside the cell following tissue injury.[7] This displacement from the intracellular space to the extracellular space moves the DAMPs from a reducing to an oxidizing environment, causing their functional denaturation, resulting in their loss of function.[7] Outside of the aforementioned nuclear and cytosolic DAMPs, there are other DAMPs originated from different sources, such as mitochondria, granules, the extracellular matrix, the endoplasmic reticulum, and the plasma membrane.[3]

The tragicomedy of this is that cytokines summon more fucking neutrophils (and other granulocytes), which dump even more destructive enzymes, damaging even more lipids, generating even more cytokines, et cetera.


The reason why this was so familiar to me was because I recognized it immediately for what it was. Feedback. Feedback in mechanical systems causes jittery, weird behavior. You can see it right off, if a hydraulic system has feedback in the controls. If you put a mic up to an amplifier, you'll hear a whine because noise in the system is being recursively amplified. Same thing with these inflammatory and oxidative pathways. Without something to dampen it (and the virus removes the dampener by suppressing the body's own antioxidant defenses) the feedback could become lethal.

The people who have good endothelial health have the dampener built-in, and so, the process never reaches that point.

Living organisms are extremely complex molecular machines, and indeed, just like simple machines, we have feedback loops as well. The problem is when positive feedback loops cause us to drift away from homeostasis.


@Derka Derka

It came from the Wuhan Institute of Virology, without a doubt. That means that Fauci quite literally funded it.





They took a bat coronavirus from caves in Yunnan province and made it more infectious to humanized hACE2 mice, which have the human version of the gene for Angiotensin Converting Enzyme 2.

That's all it would take to make a highly infectious monster SARS strain capable of ripping across the globe.

But wait, it gets worse.


The post-infection of COVID-19 includes a myriad of neurologic symptoms including neurodegeneration. Protein aggregation in brain can be considered as one of the important reasons behind the neurodegeneration. SARS-CoV-2 Spike S1 protein receptor binding domain (SARS-CoV-2 S1 RBD) binds to heparin and heparin binding proteins. Moreover, heparin binding accelerates the aggregation of the pathological amyloid proteins present in the brain. In this paper, we have shown that the SARS-CoV-2 S1 RBD binds to a number of aggregation-prone, heparin binding proteins including Aβ, α-synuclein, tau, prion, and TDP-43 RRM. These interactions suggests that the heparin-binding site on the S1 protein might assist the binding of amyloid proteins to the viral surface and thus could initiate aggregation of these proteins and finally leads to neurodegeneration in brain. The results will help us to prevent future outcomes of neurodegeneration by targeting this binding and aggregation process.

Do people realize that the proline substitution that makes the SARS-CoV-2 Spike in the mRNA vaccines "safe" is on the S2 side of the S1/S2? Do they know that S1 can be proteolytically cleaved from S2 by various means? Do they know that S1 can penetrate the blood-brain barrier on its own?


Yeah. A lot of people who took this vaccine are going to have premature Alzheimer's and dementia in a few years.

Wait a minute. What did that SPARS drill paper from 2017 say?


Reports of Corovax side effects began to gain traction. Several parents of children who experienced neurological symptoms after receiving the vaccination sued the federal government and CynBio. The lawsuit was dropped when they learned of compensation funds available through the PREP Act and the National Vaccine Injury Compensation Trust Fund.

Huh, that's interesting.



Anthony S. Fauci, MD, director of the National Institute of Allergy and Infectious Diseases, said there is “no doubt” Donald J. Trump will be confronted with a surprise infectious disease outbreak during his presidency.
Fauci has led the NIAID for more than 3 decades, advising the past five United States presidents on global health threats from the early days of the AIDS epidemic in the 1980s through to the current Zika virus outbreak.

During a forum on pandemic preparedness at Georgetown University, Fauci said the Trump administration will not only be challenged by ongoing global health threats such as influenza and HIV, but also a surprise disease outbreak.
“The history of the last 32 years that I have been the director of the NIAID will tell the next administration that there is no doubt they will be faced with the challenges their predecessors were faced with,” he said.

That's very interesting.

Time to lock the motherfuckers up.
 

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Looks like i'm going to be avoiding people with the vaccine at all costs.
This is why I still wear a mask indoors at the store. I'm not vaccinated. It's not the current Delta variant that worries me. It could be the vax creating frankenstein-variants or something even more sinister coming our way. It may just be everyone is overly angst on all sides including governments and this will pass being remembered as a the "Corona panic of the 2010's".

I think there may be a civil war going on within the Elite establishment or NWO for lack of a better term. And if you walked into a ballroom filled with them, all of us would not recognize 99% of them.
 

I’ve neglected to talk about the Wuhan death virums until now, mostly because I’ve been enjoying the spectacular fuckery on display, the gaping credulity, the mass hysteria and the moronic panic. Also because the last thing anybody needed over the last year and a half is yet another dipshit adding to the noise. My employers asked me to evaluate the situation using the best public knowledge back in March and April 2020, and I did so; I did pretty well with my estimates. I haven’t thought about it much since then, other than on the occasions in which the situation inconveniences me: and then only to the extent that I get the job done. It’s simply not that interesting, and knowing something of history I’m not particularly worried about the disease; more worried about governments using it as an excuse for totalitarian shenanigans. As such, it’s worth remembering how badly “the authorities” have handled the situation from the earliest days, in the same spirit as Matt Taibbi’s excellent discombobulation of the similarly insane Russiagate conspiracy theories. None of my statements below are scientifically or historically controversial, though I’m sure someone will attempt to argue otherwise. Here’s my list of establishment fuckups:
list.jpg

  1. It’s just the flu. Yeah, they actually said that. For a long time. I assume because Orange Man was taking it seriously.
    corona.jpg
  2. Fatality rate. People still think the infection fatality rate of the ‘rona is equivalent to that of the black death. It’s not. It isn’t harmless either. This is exactly the kind of thing our modern “technocrats” are completely unable to deal with. It’s nowhere near as bad as the Spanish Flu. It’s somewhere around the fatality rate of the 1968 Hong Kong flu or the 1957 Hong Kong flu. By the way, we didn’t react to either disease the way we did to this one; most people alive back then didn’t even remember them happening. It took months and months before the numbers were in (despite little old me figuring it out in April); now the CDC has pretty good numbers. Ones which will get you banned from Facebook if you mention them. FWIIW for Americans (who are fat, old and unhealthy compared to world standards) below 18, your chances of croaking of the thing if you’re infected is about 1 in 50,000 or 100,000. For 18-49, 1 in 2000. 50-64, 1 in 200 (a bad flu, basically) and 65+ it is 1 in 20 (much worse than the flu). The data which inform these numbers were available in April; I had the integral nailed basically from the cruise ship figures. It’s useful to compare to chances of dying of other things. For example, a 12 year old’s chances of dying of corona-chan if infected (which seems to be a rare occurrence for some reason) is about the same as being struck by lightning.
  3. Masks. The same dipshits who now think you should wear a mask while outside by yourself insisted that they were ineffective, because they knew the mask factories had long since been outsourced to China, and they wanted those masks for hospital worker to have while doing tiktoc videos. Now we have to wear them forever, because muh consensus or something.
  4. Tests. One of the reasons it appeared to be certain doom for civilization at the beginning is right censoring of the data. Tests were difficult to obtain in the early days due to production ramp ups, so they only gave the tests to people who were obviously dying of pneumonia. There were huge numbers of people who had the virus but weren’t counted because they were restricting the tests to the few who were hospitalized, presumably to distinguish them from people dying of bacterial pneumonia. But then, the data was used as if they weren’t right censored, and they came up with the skewed figures for infection fatality rate. The tests themselves have all kinds of problems. They all have both false positive and false negative rates which, afaik are large, but still fairly poorly specified. PCR tests were sometimes useless as laboratories were often contaminated. Antibody tests were only useful a few months after initial exposure. Early on Tanzania’s president (F for him) had some fruits and a goat tested and they tested positive. Schoolchildren regularly get out of school by contaminating their ‘rona tests with soft drinks. These sorts of statistical issues are core problems people have been aware of for a century, yet people acted as if there was no such thing as a false positive of false negative and treated the tests as scientistic facts, rather than statistical tools which a proper scientist or Bayesian technician might think of differently.
  5. Data censoring, false positives/negatives in general. This problem was pervasive at the beginning, and it’s still a huge problem. More tests given, more positives, even when there are no more actual cases due to false positives. Some countries are requiring a test be given before you go to a restaurant or hotel. Test rates skyrocket, then of course these countries are showing more cases. Lots of the data is like this; nobody seems to notice or care. At last peak hysteria (have we reached peak hysteria? can’t tell!), there were multiple errors per week one could publish a “you’re doing your stats wrong” paper on.
    tomatosauce.jpg
  6. Time series nature of data. The stupidity of this one absolutely blows my mind. I remember country/region X doing better than country/region Y at point T, people chimping out that country X was a model for all. This repeated enough times to make everyone who made such assertions look incredibly stupid. I can’t link to the many examples; there are too many. Just for example: vaccine efficacy data in the general population is entirely summertime; we’ll only be able to tell if they do anything come winter; it already isn’t looking real good. My theory has always been that lung borne viral ailments will basically do what they please, and humans are helpless before them. So far it looks like I am correct. This wasn’t/isn’t the only time series problem with time censored data, but it was a big one. Lung borne ailments are much worse in the wintertime, so if you’re comparing winter to summer without a model (caution; using models considered harmful), you have failed.
  7. Epidemiological Models. Neil Ferguson’s trash fire was the most famous example, credulously reported as muh science by ding dongs in the media, government and nerd establishment. At the time, the dipshit wouldn’t release the source code; with good reason. Ultimately it was a random number generator depending on a bunch of mystery constants chosen by the user, making it…. essentially someone’s opinion. People did notice (and were shouted down) the same piece of code predicted mass death that never happened with…. 2005 bird flu, 2009 swine flu, and arguably the 2001 foot and mouth disease outbreak. Ultimately he was talked into releasing source code, which the greatest living C programmer heroically cleaned up for him. Mind you this was during a huge crisis; but we couldn’t embarrass the great scientist by allowing mere peasants to review his ridiculously flawed work. Even after he was revealed to be a total mountebank, the only thing which removed this scoundrel from public influence was the revelation of breaking quarantine for a squalid affair with someone else’s nerdy wife. Similarly, there were a bunch of silly con valley goons caterwauling about ‘muh exponential growth’ who also deserve considerable opprobrium. Repeat after me: there is no such thing as exponential growth. Physical processes are logistic at best. I’m sure there were other examples; arguably too many to count.
  8. Lock downs. They mostly didn’t work. Remember when opening Texas back up was tantamount to genocide? Yeah, I remember that. Remember when everyone in Florida was gonna die unless they lock up immediately? I remember that too. Remember when Georgia committed genocide by opening in summer of 2020? Remember when everyone in Sweden was going to immediately croak? None of those things came to pass. Locked down California had a higher death rate than not-so-locked down Florida who mostly did the sane thing of protecting their numerous old people rather than locking everyone up where they could cough on each other. Sweden did better than most of Europe. Nothing big happened in Texas or Georgia when they opened up, other than small businesses coming back to life. Remember when California, Connecticut, Massachusetts saved all those lives by implementing harsh lock downs? Well, that actually never happened at all. You can juggle the statistics in a way that make it look like there is some marginal effect here, but whatever it is, the effect is marginal, where the effect on people’s every day lives was enormous and entirely negative. Aka lock downs are basically ineffective outside of some very narrow circumstances, like cutting off air travel (which the establishment was against, and they now lie about) and living on an island. Quarantine sort of works, but it needs to be applied in a sane way, for example, the way it was with measles and polio outbreaks before vaccines. Just locking everyone up doesn’t work. It’s definitely the favorite technique of tyrants; has been since the 1600s. Didn’t work back then either, but it sure made people poor and angry. Reminder: only the Swedes (and Japanese and Belorussians but we don’t talk about them) got it right. I know it makes the human soybeans real mad: but they were right and the totalitarian numskull official “experts” were wrong.
  9. Two weeks to flatten the curve. Yeah, I remember that. Somehow that turned into “oh you idiots are going along with this; let’s do it forever.”
  10. Ventilators. Remember when car companies were going to ramp up “wartime production” on ventilators so we could all stay alive in our hospital cucksheds? Remember when amateur scientists and hacker soyboys were inventing home made ventilators to save us all? Well, they quietly stopped talking about this, because it turns out these things were basically murder machines. There are now numerous videos of the things filling up landfills. This is a case study in large scale iatrogenics. Countries which didn’t have literal tons of ventilators did much better than countries which had the things. The low oxygen levels from the “ground glass” lung destruction effect were more effectively and easily treated with … oxygen. And leaving people alone, rather than death pressure fucking their lungs with some demonic contraption which probably helped spread the ‘rona in hospitals. Really the technocratic obsession with these ridiculous machines ought to be a case study in the abnormal psychology of twee nerds. Even at the beginning when I went along with the crowd and thought there might be a need for such machinery there was something unseemly and disgusting about the gruesome glee among certain schnerds to shove a tube down everyone’s throat and pressurize their lung sacs with …. muh technology.
    vents.jpg
  11. Overloaded hospitals. Never really happened. Sure some hospitals were busy. Some hospitals are busy every year. The preposterous spectacle of TikTok dancing nurses and empty hospitals was pretty bad, as were nitwits cheering on medical workers like trained seals, and the insistence that the hospitals really were overwhelmed and you had to be some kind of conspiracy theorist to deny this. Then the layoffs started. You see, telling everyone who isn’t dying of ‘rona to stay away from the hospital more or less bankrupts the hospitals. You have to print a shitload of skrilla to keep them ticking over doing nothing when no actual corona-virums patients show up. Which is what happened in most places. Since corona-chan is a physical thing, you’d more or less expect it to be geographically concentrated rather than evenly distributed over the set of all hospitals; some hospitals overwhelmed, as indeed some were, but the vast majority doing nothing but TikTok videos. Lying about it didn’t inspire a lot of confidence in the proverbial powers that be. Anybody could drive by their local hospital and see that it was empty, and that the army tents set up outside were also empty. Classic central planning blunder, and totalitarian denial of reality afterwords.
    epicenter.jpg
  12. Nursing Homes. Remember when several US governors (NY, NJ, PA, Mich) thought the hospitals would be so full of meat puppets hooked up to breathing machines they would overflow? Remember when the same US governors put non-ventilated corona virus patients in nursing homes with all the old people? Remember how pretty much all those governors states had huge fatality rates? Well, these facts are all related, and those governors play acting as miniature dictators should be held to account for murdering grandpa. Instead they’ll be held to account for awkward flirtations, because America is a profoundly unserious country which takes accusations of creepiness more seriously than boomer genocide. BTW wrote this before it actually happened.
  13. Airborne/aerosolized pathogen. It was abundantly obvious from the goddamned cruise ship data that the virus was airborne; from the very get-go. Some sniffly lawyer in New Rochelle spread it to half the big apple in the early days. Choir members in churches had a very hard time. No matter how many “fomites” one man could spread, even a huge slob, it was obvioso it had to be airborne. Only now are people beginning to admit this. After a year of learned magnificoes and most official channels stating categorically that this couldn’t possibly be true. Instead we had people doing ridiculous things like washing their groceries with bleach because muh fomites. This obvious fact could have informed policy; you can do shit like install better air filters instead of security theater like neurotically constantly sterilizing your hands. The “over cautious” approach of health and political authorities to obvious truisms like the fact that the ‘rona was an airborne pathogen is extremely typical of their responses to everything. If it was politically convenient they were absolutely sure of themselves, even if it was obviously wrong. Faced with ridiculous, preposterous amounts of evidence, they dragged their feet, demanded double blind studies and other such theater, and eventually, a year or two later, admitted they might have been wrong, but how dare you notice that they were wrong.
    What really bugs me: there is still really no good information on how it spreads. How do superspreader events work? Let’s reduce it to the basics. Is it snot? Farts? Does it come from higher lung pressure such as singers or fat people experience? Nobody wants to tell. Perhaps the real answer is …. politically incorrect -maybe it’s the disgusting, shambling obese people who spread it. Those who would deprive the unvaccinated of their civil rights; would you not be willing to deprive fat people of theirs? They seem more dangerous to me. Certainly they’re harder to look at. Both are a personal choice; choosing to be a disgusting fatbody is easily more deadly even in the absence of any new corona viruses.
  14. Cross-immunity/asymptomatic. A friend of mine tested positive for ‘rona antibodies; he felt a bit run down and wondered if he had been exposed. He had been (modulo false positives). I had spent the previous week being a tourist with the guy; for all I know I was exposed to it as well (I felt fine; mostly ate and drank too much). There is now abundant evidence for both asymptomatic carriers and cross immunity from exposure to other corona viruses. For months this was dismissed as a conspiracy theory. Now it’s accepted as fact.
  15. Multiple infections. People can indeed get the ‘rona a couple of times. This is used as a justification for vaccinating people who already had the disease. This practice is, of course, known to be bullshit: that isn’t how the immune system works. Believing that somehow the vaccine is better than the infection in protecting against reinfection is stygian ignorance, and attribution of nonexistent magical powers to muh technology. People administer the vaccines to people who had the illness anyway. Why? Don’t know, but considering the other nonsense in circulation, you can’t blame the tinfoil helmet types for being a bit suspicious of the “authorities.” Frankly, vaccinating people who already had the disease sounds dangerous to me. Since the vaccine sides are related to autoimmune problems when your cells start producing viral proteins; that’s going to happen even more if you’ve already got an immune system that knows what to do; such as among previously infected people. FWIIW every indication is that natural immunity by itself is superior to prevent future infection.
    vax.png
  16. Taking kids out of school. Granted this was mostly an American shitlib school district problem, but I suspect a lot of teachers unions will ask for next year off as well, so it’s worth mentioning they were wrong about this also. Many countries did not cancel school, and nothing bad happened to them.
  17. Bill Gates is a doctor/expert/whatever, rather than a college drop out who won the sociopath lottery. There is really no more reason to listen to Bill Gates about wuhan lung butter than the theories of the fruit merchant on my street corner. Even his wife got sick of listening to this sinister sperdo’s bullshit, which, mercifully, seems to have temporarily made bubble head Bill go away.
  18. Risk factors. Just like with HIV/AIDS back in the 80s, they’re treating this as if we’re all equally at risk. Just like with HIV/AIDS we’re absolutely not. You’re pretty much not getting teh GRIDS unless you inject a few gallons of randomly sampled man batter up your keister, or share needles with people who do (or who share needles). Similarly, you’re not dying of the wuhan death virums unless you’re already dying of something else; obesity, diabetes most prominently featured in the united states, but there are a few others. As was the case with the GRIDS, tragically, there were a few exceptions which proved the rule. Unfortunately the same evil dipshits tried to get us all to draw the wrong conclusions on this; just as they are now -parading out “young and healthy” 400 lbs monstrosities taken in “the prime of life.” It’s sad hemophiliacs and blood transfusion recipients in the 80s died of AIDS, just as it’s sad 400lb 48 year olds are dying of wuhan-coof, or 80 year old nursing home residents are taken a few years before their allotted times. On the other hand, seeing obviously fit 25 year old women nervously jogging outside with their masks on is pretty fucking ridiculous.
  19. Treatments/prophylaxis. There was reasonable early evidence hydroxychloroquine has some salubrious effect. However Orange Man liked it, so it had to be proven wrong with fraudulent studies. There’s still some evidence it might have benefits. Plenty of other substances have strong evidence of effectiveness, including the humble “vitamin-D hammer.” At this point, the evidence that dying of corona-chan is partially dying of vitamin-D deficiency is so overwhemling, all public health officials should be held criminally liable for not suggesting everyone start taking 5000 iu a day. It’s good for you and will prevent other problems even if it has no effect on your Chinese lung-butter survival rates. Similar comments may apply to zinc. Ivermectin appears like it could be efficacious, both as a preventative and a treatment; maybe it is, maybe it isn’t -but it is absolutely politicized in the US at least, and I could get banned on most social media platforms for suggesting we look into it. Of course, there’s no money to be made using common and harmless drugs and supplements. More to the point, in the US, you can’t legally use experimental vaccines if there are efficacious treatments available. Saying these things, which appear to be statistical facts, is considered so dangerous, tech companies will ban hammer you for the crime of saying them. There are still huge efforts to prevent people knowing about these potential treatments, and US doctors are basically not allowed to use them, even though the side effects are fewer than that of OTC medicines such as Tylenol. Even if the above treatments were useless or marginal; the government approves useless or marginal treatments all the time. But they typically only do so when there is money involved. They even did it for corona-chan; remdesivir is probably useless, but it’s patented and it sure does make some money Gilead can use for campaign contributions. Instead of making these off-label treatments available to doctors, the swine remove a common and completely harmless OTC supplement, N-acetyl-cysteine from circulation when it proves it may be of utility in treating this illness. What kind of garbage human would even consider doing this? The kind of goon we hire to run the FDA apparently. Can everyone say “regulatory capture” boys and girls?
  20. Smokers. In the beginning it was hypothesized that the Chinese were dying of this new virus because many of them smoke and there’s lots of bad air in Chinese cities. Then the actual data started coming in. Turns out smokers are much less likely to be hospitalized and die of the ‘rona than non-smokers. This makes right thinkers everywhere sad. They even post obviously false papers reassuring themselves that smoking is bad mkay, but it is a huge, enormous and won’t go away statistical effect, even a dose dependent one; not quite the effectiveness of vaccines, but good enough nicotine was tested in clinical trials. I’m not suggesting people go out and buy a carton of marlboros (lord knows there are enough fearful idiots out there some would if muh science experts told them to), but it is one of those things where the “experts” are at a total loss; something they’ve been telling us is certain death for decades actually has some health-conferring benefits (FWIIW, also for Parkinsons disease). It’s part of the morality of the current year clerisy that smoking is bad mkay. A serious and cold blooded actual technocracy would accept that it confers some benefit as a coronavirus prophylaxis, figure out why smokers don’t die of rona as often as “healthy” people, and how to use it to our benefit, rather than posturing with paternalistic purity preening. I’m told by amateur historians tobacco was thought in olden times to have protective effects against the grippe and other plagues; maybe our forefathers were right on this one. Either way it makes fools of our “experts” and is worth noting.
  21. Regime approved riots and spontaneous demonstrations of gratitude and joy didn’t spread corona virums, but evil nasty and filthy republican protests did somehow, because, I dunno, muh white privilitch or something.
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  22. Censorship as public health measure. This is a truly preposterous thing in light of all of the above. Not only are Alex Jones tier tin-helmet types being censored, but respectable scientists who do not conform with the prevailing establishment opinions are also being censored and demonized. The very concept of “freedom of speech” is that voices outside of the consensus might be right about some things, and a society which practices free speech is better off than one which attempts totalitarian thought control. Of course, people are prey to all kinds of bad ideas, but our “elites” are also (allegedly) people, and it’s obvious from the above they don’t really know what they’re talking about either. Science only works in conditions of free speech, you fucking murble-wurble-wub-science nincompoops.
  23. Delta as transmissible as Chicken Pox. This is an overt lie, which I suppose they’re getting away with because of censorship as a public health measure. Chicken Pox has a reproduction number R0 of 10 or 12. Right now, the delta variant is dominant in the US, and the reproduction number R0 is below 2 in every state. Why not go for broke and say it’s 10x worse than measles (R0 of 12-18)? I mean, if you’re just making up bullshit, why not go big?
  24. Honorable mention: some of the nonsense was pretty fringe even at the time (suggestions of glory hole use for safer sex), but notable for being taken vastly more seriously than all the shit they got wrong and banned from asociable media. My very favorite was the New York Times suggesting all men become estrogen treated castrati to protect them from the fearsome ‘rona. Vitamin-D or ceasing to be a disgusting fatbody, naaaah; just chop your nuts off and take some birth control pills and everything will be great. This should probably be enshrined as some kind of apotheosis of contemporary “technocratic” thought. Because if there’s one thing we need right now, it’s more castrated men.

Could be wrong can’t tell yet:
  1. Vaccinations efficacy. Most people think of various kinds of ronavax as a sterilizing vaccination the way polio vaccines are; not so. This has obvious and non-obvious consequences. The obvious one is you could be vaccinated and get sick or die of ‘rona anyway. The not so obvious one is that this will simply cause the virus to become more easily spread to people who have been vaccinated: that’s how evolution works. It may also become more deadly: this happened with a non-sterilizing vaccine for a chicken herpes virus. While the preliminary large scale evidence for vaccination effectiveness is reasonably convincing by now, it’s far from definitive, and is entirely short term. Back when it seemed it might be Orange Man Vaccine, they sure were cautious about shipping things too soon. It is entirely possible vaccinated countries start getting the ‘rona at rates comparable to what one would expect come winter time, we’ll know this science experiment was a towering error. Especially if the deaths peak up as well. I’m not saying that will happen, but it could happen, and nobody should accept “muh variants” and “muh booster shots” as explanation and solution.
    Indeed, eventually, vaccine or no vaccine, the virus will eventually be just another coronavirus endemic in the populace, just as it was in 1889 when HCoV-OC43 probably became endemic. There’s an obviously true thing our psychological terrorist “technocrats” and their enablers won’t tell you. Barring huge breakthroughs SARS‑CoV‑2 will be with us forever. It will be with us for so long, eventually it will no longer be called SARS-Cov-2; it will have some other more innocuous name like HCoV-NL63 does. It will eventually just be another respiratory virus of no particular distinction. No lung borne ailment, let alone a viral one, has ever been eliminated by humanity. FWIIW the attention paid to coronaviruses now may end up telling us a lot of sudden death or clotting or viral pneumonia is associated with rare reactions from the other endemic coronaviruses. Would be interesting to know; probably a good many human ailments we attribute to nonsense like eating bacon are actually viral or bacterial; our science is so bad here it took until 2005 to fully recognize the fact that human ulcers were caused by Helicobacter pylori.
    Oh yeah, while I’m at it; there sure are a lot of “95% effective” vaccines. I have not looked closely at the raw data, but the probability of there being multiple 95% effective vaccines seems pretty low to me; even based on Benford’s law. When I see 95% all I can think of is p-value hacking. FWIIW CDC fucked up looking at breakthrough cases, because, I guess, it would be bad marketing for the vaccines. Evidence becoming overwhelming though. Iceland is looking pretty bonkers. So much so, Iceland’s chief epidemiologist has stated that herd immunity must be achieved via viral infection. Only “kooks” seem to have noticed this, and it may be wrong, but Iceland unlike the US is still a serious country, so it must be taken at least as seriously as the idea that a 17 year old who already had the ‘rona must be vaccinated.
  2. Vaccines: strategy As evidence mounts the vaccine wasn’t as effective as the propaganda said, we’re receiving calls for mandatory vaccination and persecution of the unvaccinated from precisely the same people who told us we needed to have a war in Mesopotamia and totalitarian surveillance state. David Frum has literally never been correct about anything, and the fact that this ridiculous, sinister neocon lizard is still taken seriously is in itself completely discrediting of “the establishment.” Since deplatforming and un-personing is now a fashionable way of dealing with sources of harmful “misinformation,” if anyone is deserving of this, it is David Frum, whose ideas have literally cost the US trillions of dollars, tens of thousands of lives, and sown chaos in large swathes of the world and caused 800,000 violent deaths. You could run a pretty good public policy institute by asking Frum what he thinks, and then suggesting the country do the opposite. For certain, Frum has done vastly more harm in the world with their actual misinformation than people like the Alex Jones.
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  3. Vaccines: dangers. These are unquestionably the most dangerous vaccines fielded for mass consumption for decades; there’s been around 10,000 directly attributed deaths in the US, and possibly more that didn’t get counted. There has been reasonable speculations that vaccinations may be as dangerous as the virus itself at the present levels of infection herd immunity. This is almost certainly true for younger people; now officially so as far as the UK government is concerned, and people who want to vaccinate your kids are doing so entirely out of political malice. It’s obvious now that there is some cross-immunity with other endemic coronaviruses. Unfortunately it doesn’t show up in antibodies; only in the T-cell immunity memory system. If there were a test for this, one could figure out who to give the somewhat shitty and dangerous vaccines to and leave everyone else alone.
    Oh yeah, in case you need more things to worry about, it’s entirely possible the present generation of vaccines cause something called antibody dependent enhancement, making you more likely to die if you get a wuhan-lung butter infection on some time scale (remember, everything here is a time series process). They claim this hasn’t happened, but it’s still pretty early, and I’m virtually certain that a statistician who found early evidence of it would have a hard time informing people about it, because censorship is the order of the day. FWIIW I am tracking both things, and so far it hasn’t showed up in the overall mortality statistics.
  4. Lab Leak Hypothesis. It was declared definitively that only schizos and Russian influence agents would believe the insane and silly idea that the Wuhan coof might have come from a Wuhan biological warfare laboratory, and it was obviously some Chinese guy eating a bat sandwich which gifted the world with this fun new disease. Unfortunately, the guy who originally made this statement was deeply involved in US funded research on coronaviruses in Wuhan, as was the dipshit who told us AIDS might be airborne in the 80s. This is a pattern which repeats itself a lot; the guilty more or less returning to the scene of the crime. Nick Wade is a freaking hero for bringing this out of 4chan where it was first noticed and in to public debate, and the Bulletin of Atomic Scientists deserves a lot of credit for being the first mainstream institution to give the article air. This, of course, could also be wrong; other people point out that enemies of the US were hit particularly hard by the virums…. and afterall, our people were funding the Wuhan lab. Could have been a deliberate release by US neocon types. It’s not like the US never did such a thing before. I suppose it could also have been a bat sandwich. None the less, if the “experts” got their way, this wouldn’t be under consideration; and it is of supreme importance that people get to the bottom of it and prevent it from happening again, whatever the origin was.
  5. Immunity syndrome. Locking people up and masking them for a year and a half has consequences. All the masking and social distancing means you didn’t get your usual amount of viruses living in your respiratory tract. New Zealand, for example, has a weird outbreak of something called respiratory syncytial virus (RSV). Israel has had an unprecedented outbreak of summer colds, RSV and flu now that they’re back to “normal.” We have no idea how this will play out; the immune system is pretty weird, and people don’t realize the human lung has a biome; an ecology, just like the little buggers that live in your intestines. Remember, Polio was basically caused by keeping babies clean; it was a common human virus, but babies all were infected with it before their nervous systems could be damaged by it. Once they stopped being infected in early infancy, the full horror of the disease became apparent. Something like this could easily happen, and it hasn’t been considered by official “experts” at all.
  6. Muh variants. They keep saying Delta is more dangerous to young people. Except the data says it isn’t. Maybe some day data will come out saying the delta variant is more dangerous, but it sure looks like it’s less dangerous to me. It is apparently slightly more transmissible, but that’s not the same as “more deadly.” That’s kind of how evolution works; of course the dominant strain will be more transmissible and less debilitating.

Fun hatefacts <tm>: the CDC’s figures for total deaths appear to be accurate. The number of deaths they attribute to corona-chan is approximately equal to the number of excess deaths during the time of the ‘rona. Kudos to the little guys working on these numbers at the CDC; statistical lions led by donkeys. Schizos; no denying it, you can’t hide dead bodies. Of course, most of them were, well, old and fragile. Over 65s have a 1/20 risk of death if they catch the Wuhan flu. Of course, they have about the same chance of death in a given year period, in the absence of something like corona-chan. Being old radically increases your chance of dying. I know it’s hard for some of you to deal with, but it’s a fact. FWIIW, if you’re a 30 year old man, you have a 1/2000 chance of dropping dead of ‘rona if you catch it, or, like, a 1/1200 chance of dropping dead this year from being a 30 year old man (your long term probability of death is 1/1 BTW). Women have it easier of course; both of ‘rona and of being alive.

The technocratic managerial state, the main western governmental system since 1945, has failed. It’s not a big surprise, as most of the people involved in it these days are nothing like bloody minded and competent Glen Seaborg tier technocrats who actually practice scientific thought. They’re just regime apparatchiks, generally fourth rate intellects and personalities whose spiritual level is somewhere between dishonest clerk and agricultural slave. They’re sleazy dimwit ninnies role-playing as learned wizards. This is the West’s Chernobyl moment for this manner of technocrat. These are people so weak, cowardly and generally useless, they can’t abide being contradicted on the freaking internet. For all the caterwauling about “misinformation” -most of it seems to come from the self-proclaimed “experts” and their human soybean fans and hysterical enablers. Even if those clowns started machine gunning critics like the Soviet apparatchiks they resemble, this is still how they look to the narrow aristocracy of sensible people:

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Muh wub science bubbleheads getting 5 different vaccines to protext themselves from death, bleaching their groceries and wearing masks by themselves in an automobile make voodoo adherents look sensible. The fact that large swathes of the population has no respect for the clodpated numskulls making the decisions is as predictable as ballistics; nobody should -they’ve been wrong about virtually everything. The fact that all these tittering doofuses can do in response is … become more authoritarian probably means their time in power is coming to an ignominious end. Whipping up twitter mobs to, like shout down the actual scientists thinking about the problem is not as they say, a sustainable system for alleged technocrats. Much as I’d love to see a few of them hanging from the guts of news reporters, pour encourager les autres, depriving them of their pensions and forcing them to get jobs at the Apple genius bar would probably hurt them more. If you really want people to “believe the experts” the “experts” could try being correct more often, and admitting their numerous and egregious failures. People with power should be held accountable, and they certainly shouldn’t be applying censorship when they’ve proved they have no fucking idea what they’re talking about.

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Tierney scooped me, more or less, but his thing isn’t a cool list like mine:
https://www.city-journal.org/panic-pandemic?wallit_nosession=1

“Whatever the pandemic’s origin, the response to it is the worst mistake in the history of the public-health profession”

Historical fuck up:
https://www.bbc.com/future/article/20200918-the-fiasco-of-the-us-swine-flu-affair-of-1976
https://www.history.com/news/swine-flu-rush-vaccine-election-year-1976

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Edit add: I keep forgetting to mention it, but animal reservoirs (cats, rats, birds; even deer) are probably driving a lot of this, and probably invalidates leaky vaccines as a strategy.
 
Between the Emmys not needing to wear masks because "exceptions are made for Hollywood", the San Francisco mayor partying maskless with BLM and talking about "the fun police" when it is HER mandate, and all the pictures of AOC at the gala being maskless while all the "help" needed to be.

I know it's not new, but I'm shocked at how blatant right now the elites are just openly saying "we don't need to follow the rules because we are better than you." Maybe I'm just naive, but I don't remember their distain being THIS public before. Usually they try to hide or deny it; now it's just openly "fuck you, you're not important; I'M important!"

View attachment 2557762
If anyone says anything to you about not wearing a mask just ask them if they saw the Met Gala or the Emmys. If wearing mask wasn't necessary for anyone there, it's not necessary for you.
 
The only way the elite would throw Fraudci under the bus would be to appease the masses of civil unrest the hasn't been seen since the various revolutions in history -- which we are probably no where close to being.

They wont

he is 81 years old. The consequences of his decisions wont be seen to till after he has died.

Clearly right now all he cares about is enriching himself for the benefit of his bloodline.
 
I sure hope he vets his bodyguards and personal doctors, otherwise he's going to saying hello to the presidents of Haiti, Tanzania, and Burundi soon.
What's the deal with the odd last names containing the letter Z just kind of plunked in there?

Like Peter Strzok.

I don't think we can trust those people. >.>
It means they're Polacks, a race not known for their intelligence.
 
This is why I still wear a mask indoors at the store. I'm not vaccinated. It's not the current Delta variant that worries me. It could be the vax creating frankenstein-variants or something even more sinister coming our way. It may just be everyone is overly angst on all sides including governments and this will pass being remembered as a the "Corona panic of the 2010's".

I think there may be a civil war going on within the Elite establishment or NWO for lack of a better term. And if you walked into a ballroom filled with them, all of us would not recognize 99% of them.
Go to the Biden News Megathread and check out Gehenna's posts for good (possibly not just) speculation on the internal civil war.
 
4chan's discussion of ivermectin has lead to schitzoposting about butt worms
Hmmmm that's some good schizoshit.
So in Germany there was a "pathology conference" where people claimed that many more people died of the vaccines than officially stated, and they showed funny microscope pictures of weird shit floating in the vaccines, stuff looking like like submarines and shit.
So obviously this should be easily refutable, right? The goodthinking REAL scientists should just swoop in and roflstomp those people with facts and logic, eh?
Of course not, instead the media is out in force to ad hominem the fuck out of everyone involved in that conference. Don't even think about that conference, normie, the production company behind the video is bad people!
Of course, the videos were deleted immediately.
 
Don't even think about that conference, normie, the production company behind the video is bad people!
Of course, the videos were deleted immediately.
"When you tear out a man's tongue, you are not proving him a liar, you're only telling the world that you fear what he might say." - Some manlet faggot
 
"When you tear out a man's tongue, you are not proving him a liar, you're only telling the world that you fear what he might say." - Some manlet faggot
I see more and more people being actively against asking any sort of questions if the answer could "radicalize" people. The same people think they're being all about democracy and the good guys.
Now that someone has been killed by an anti-mask guy here in Germany they have even more reason to a) heavily police any sort of criticism of the Coof restrictions and making anything deemed "disinformation" illegal, b) heavily crack down on critics and their "networks", i.e. not allowing demonstrations and even if it's allowed basically restrict them to death, and c) move against the far-right AfD party since they're the main party in the parliament that is against the restrictions and quite critical of everything the government does. Basically, ban the third-biggest party less than a week before the federal election.
 
Hmmmm that's some good schizoshit.
So in Germany there was a "pathology conference" where people claimed that many more people died of the vaccines than officially stated, and they showed funny microscope pictures of weird shit floating in the vaccines, stuff looking like like submarines and shit.
So obviously this should be easily refutable, right? The goodthinking REAL scientists should just swoop in and roflstomp those people with facts and logic, eh?
Of course not, instead the media is out in force to ad hominem the fuck out of everyone involved in that conference. Don't even think about that conference, normie, the production company behind the video is bad people!
Of course, the videos were deleted immediately.
There is a grain of truth, there. Latent toxoplasmosis does affect human behavior, sometimes quite profoundly.





 
4chan's discussion of ivermectin has lead to schitzoposting about butt worms
Sounds like the plot for a decent scifi thriller novel. The Mu Vector.
Was there any official explanation as to why Billy Bunter / Fat boy/ Boris Johnson was happy to not wear a mask while round dirty anti vaxxrr Bolsonaro indoors, but slapped a diaper on to meet whatever the token diversity hire Vice Presidents name is while outside?

No, but he probably did it to look good in front of the press, and because he's a slimy chameleon turd. The American press and the BBC screech all the time about masks, so he'll wear one to avoid being seethed at. As for Brasil, he probably didn't want to look like a pansy in front of Bolsonaro.
 
Hmmmm that's some good schizoshit.
So in Germany there was a "pathology conference" where people claimed that many more people died of the vaccines than officially stated, and they showed funny microscope pictures of weird shit floating in the vaccines, stuff looking like like submarines and shit.
So obviously this should be easily refutable, right? The goodthinking REAL scientists should just swoop in and roflstomp those people with facts and logic, eh?
Of course not, instead the media is out in force to ad hominem the fuck out of everyone involved in that conference. Don't even think about that conference, normie, the production company behind the video is bad people!
Of course, the videos were deleted immediately.
I hope someone had re-uploaded these videos elsewhere.
As for Brasil, he probably didn't want to look like a pansy in front of Bolsonaro.
All the pansies might feel insulted to be compared to Boris Johnson.
 
I was making a (somewhat) joke/observation about how many people (Brzezinski, et.al.) have this surname type; being in the city I am with a large contingent of Poles I am well aware of the etymology but they're still a bitch to pronounce lol.
 
I was making a (somewhat) joke/observation about how many people (Brzezinski, et.al.) have this surname type; being in the city I am with a large contingent of Poles I am well aware of the etymology but they're still a bitch to pronounce lol.
At the discussion in 1759, the rabbis energetically repulsed their opponents. After the discussion the Frankists were requested to demonstrate in practice their adherence to Christianity; Jacob Frank, who had then arrived in Lwów, encouraged his followers to take the decisive step. The baptism of the Frankists was celebrated with great solemnity in the churches of Lwów, with members of the Polish szlachta (nobility) acting as god-parents. The neophytes adopted the names of their godfathers and godmothers, and ultimately joined their ranks. Frank himself was baptized in Lwów (September 17, 1759) and again in Warsaw the next day, with King Augustus III as his godfather. Frank's baptismal name was "Joseph" (Józef). In the course of one year more than 500 individuals were converted to Christianity at Lwów, and nearly a thousand in the following year. By 1790, 26,000 Jews were recorded baptised in Poland.

Strange how a subset of Polish Christians only intermarry among themselves and have secret rituals. Well, it probably doesn't mean anything.
 
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