Technically, now the Embracer Group owns the rights to Duke since they bought Gearbox in April.
Let's hope someone within that holding group has a heart for that franchise and wants to do something with it.
As uninspired and lame as DNF was, "The Doctor Who Cloned Me" was a step in the right direction, and showed that with decent writing and a competent, enthusiastic team developing the game, Duke could still be a good character, and, dare I say it, a good game.
Just fully detach whatever comes next from Duke Nukem Forever. Forget that game ever existed. I still say let VoidPoint have it. Imagine what they could do with their experience in the Build engine, and with a bigger franchise's name and budget. That'd be the best fit, I think.
Also financially smart. That niche title won't cost a ton to make, but will bring in cash from loyal Duke/Build engine fans. If that game turns out to be successful, especially outside of that niche, then that could be used as a first stepping stone into bringing Duke into a more modern engine. And if not, then at least he could be a mainstay name in the retro/boomer-shooter niche.
Man, I sure can sperg about DukeDaddy.
Edit: DukeDaddy, not DudeDaddy.