Covid/mRNA Vaccine Info General - "Covid Seasonal Flu Vaccines is Society's New Normal" - FDA

[Shaka Brah]

Apparently A.30 variant is vaccine-resistant. So, what now?
https://www.nature.com/articles/s41423-021-00779-5

"Sorry goys your third and fourth boosters weren't enough, time to go back to lockdowns."

Meanwhile Biden announced that Third Worlders are exempt from the vaccine mandate for travel.

 

[EyelessMC]

Apparently A.30 variant is vaccine-resistant. So, what now?
https://www.nature.com/articles/s41423-021-00779-5

Unholy hell

The first paragraph of this reads like they're covering their bases against potential "anti-vax" slander they know could likely come after them for this and it's written with finesse. The rest of it, however, is as nearly impenetrable for laypeople as most studies. Here's the full picture of graphs they posted:

Spoiler: It's a very large picture

Below are just a couple choice quotes for what I could discern as some average joe. If I'm wrong about anything, correct me. If anyone else here can make some English out of all this Greek it would really do a great service, especially since I'd prefer to update the OP with this information in a way that's easier to understand for laypeople:

Spoiler: Quote Excerpts

Compared to the S protein of SARS-CoV-2 B.1, which circulated in the early phase of the pandemic, the S protein of the A.30 variant contains 10 amino acid substitutions and five deletions (Fig. 1a and Supplementary information, Fig. S1a). All deletions along with four substitutions are found in the N-terminal domain of the surface unit S1, which harbors an antigenic supersite that is targeted by most neutralizing antibodies not directed against the receptor-binding domain (RBD) [5]. In addition, three mutations are located inside the RBD, which binds to the cellular receptor ACE2 and constitutes the main target of neutralizing antibodies (Fig. 1a). Two of these mutations, T478R and E484K, are located close to the ACE2 binding site (Supplementary information, Fig. S1a), and E484K is known to reduce susceptibility to antibody-mediated neutralization. Finally, two mutations are located close to the S1/S2 cleavage site, and one mutation is found in the transmembrane unit S2, which facilitates fusion of the viral envelope with cellular membranes (Fig. 1a).

So from what I could discern from this, the new variant under the microscope here is a fledgling right now, at least in terms of global spread. This "A.30" variant is unlike the previous because of its huge umber of mutations and what those mutations make it capable of, most notably being its increased infectivity and the ability to no-sell antibodies.

In summary, A.30 exhibits a cell line preference not observed for other viral variants and efficiently evades neutralization by antibodies elicited by ChAdOx1 nCoV-19 or BNT162b2 vaccination. SARS-CoV-2 entry into cell lines depends on S protein activation by the cellular proteases cathepsin L or TMPRSS2 [8], and activation by the latter is thought to support viral spread in the lung. Therefore, it is noteworthy that enhanced A.30 entry was observed for cell lines with cathepsin L (Vero, 293 T, Huh-7, A549 cells)—but not TMPRSS2 (Calu-3, Caco-2)-dependent entry [8].

That's weird, isn't it? I wonder what that means. Makes me recall what @Otterly had been concerned about, the very thing @Fanatical Pragmatist and others ITT had mentioned, too--that this mad push for mass vaccination could incite evolutionary changes in Covid's variants that would make it far more dangerous, if not deadlier, than before. Is this change in the A.30 variant due to the new environment created from the vaccine mandates?
Of course it wasn't just Kiwisthis was also a concern of many noted scientists who had published a peer reviewed study on the issue, as I recall. Might be in one of the PDFs in the OP for those interested.

Thus, one could speculate that A.30 might use cathepsin L with increased efficiency and slight (but not statistically significant) resistance of A.30 against the cathepsin L inhibitor MDL 28170 supports this possibility (Supplemental information, Fig. S1c). Notably, robust entry into cell lines was combined with high resistance against antibodies induced upon ChAdOx1 nCoV-19 or BNT162b2 vaccination. Neutralization resistance exceeded that of the Beta (B.1.351) variant, which is markedly neutralization resistant in cell culture and, in comparison with the Alpha (B.1.1.7) variant, is less well inhibited by the ChAdOx1 nCoV-19 vaccine [9].

So that's where the header comes from and the big concern here is that it's not just a sudden change in the variant which produced this result. There's signs even in certain previous "variants of concern" (VOC) that each new iteration of Covid was slowly starting to develop this WWE no-sell of antibodies. A.30 is the latest iteration to show how this mechanism has improved as the virus develops into newer strains.
At least, from what I can gather.

Nevertheless, heterologous ChAdOx1 nCoV-19/BNT162b2 vaccination, which was previously shown to augment neutralizing antibody responses against VOCs compared to corresponding homologous vaccinations [7, 10], might offer robust protection against the A.30 variant.

Here we need to take a brief detour into what they're talking about. The term "heterologous" means "derived from a different species", according to Meriam-Webster. On the page for its definition is a citation from this article below:

The immune system responds in varying ways to different vaccine technologies. - CNN, July 2, 2021
Just wanted to highlight that and a certain remark in this excerpt because it shows how exceptional the individuals are who think people having adverse effects to the vaccines--or any vaccines for that matter--are just liars or loons. Not everything is some anti-vax Q-tard conspiracy.

Anyway, it seems like the main crux of the heterogloglulous notion is for people to get different boosters for the Covid vaccines. If so, this correlates to the growing study and consideration of the Covid vaccine's potential increased effectiveness when mixing jabs (See OP for more detail).
In this A.30 study, the scientists appear to posit that if A.30 has developed mutations to no-sell the antibodies then mixing the vaccine boosters could help, if at least to some extent. Again, that's just from what I could gather. It'd be some good news if not for the overall looming message:

Collectively, our results suggest that the SARS-CoV-2 variant A.30 can evade control by vaccine-induced antibodies and might show an increased capacity to enter cells in a cathepsin L-dependent manner, which might particularly aid in the extrapulmonary spread. As a consequence, the potential spread of the A.30 variant warrants close monitoring and rapid installment of countermeasures.

Forget Delta and forget Delta Plus. If the vaccine madness can't help us from those then we are in dire straights if A.30 spreads like its variant predecessors.
Worse still is the way each variant seems to have another sign of getting around the antibodies, each one a little more than the last. A.30 is not simply something to be concerned about on its own. It may also be a warning of things to come for future variants.

 

[Fanatical Pragmatist]

Apparently A.30 variant is vaccine-resistant. So, what now?
https://www.nature.com/articles/s41423-021-00779-5

So at least 3 variants, "Mu", "Delta Plus" and now A.30 have all evolved vaccine resistence.

Evolution: III
Uber-Vaxxers: 0

Trust the science, guys!

 

[Feline Supremacist]

What's the point if this nigger chink virus keeps mutating?

 

[PuffyGroundCloud]

What's the point if this nigger chink virus keeps mutating?

moar lockdowns and boosters I guess

 

[Fanatical Pragmatist]

What's the point if this nigger chink virus keeps mutating?

Supposedly if we vaccinate everyone fast enough, then it won't have any hosts to jump to.

Which is dumb because at least three lineages have already evolved resistance so far (expect more in the coming months), making the current crop of vaccines already outdated, and also btw you'd have to vaccinate the entire world plus every wild bat and deer in a matter of months to try and beat a virus that has like 1000x the mutation rate of most Influenza species.

Its also retarded, because its like expecting bacteria to die from penicillin again by giving everyone penicillin or expecting western gartersnakes to become vulnerable to newt tetrodotoxin by ensuring their prey is all poisonous.

 

[Car Won't Crank]

What's the point if this nigger chink virus keeps mutating?

Control of the masses

 

[Mr Bunny]

What's the point if this nigger chink virus keeps mutating?

That's the real question isn't it

So at least 3 variants, "Mu", "Delta Plus" and now A.30 have all evolved vaccine resistence.

Evolution: III
Uber-Vaxxers: 0

Trust the science, guys!

Now now, you can't say the vaccine will fail until we start giving it, just the same as not knowing if it's safe for kids age 5.

 

[GoysGoneWild]

What's the point if this nigger chink virus keeps mutating?

More lockdowns, more mask bullshit, more attacking people who question the increasing schizophrenia coming out from our "experts" and "institutions". More transfer of wealth from the not giga-rich to the giga-rich. Further implementation of social control. Further regimenting and training of mindless retards that imbibe every contradictory thing put out from our "betters". More shit like vaccine subscriptions. Further isolation of people that dare to not go along with it all.

 

[EyelessMC]

- crime has risen 30% in USA
- nearly 1/3 of all police and paramedics in major cities are questioning leaving because of vaccine mandates
- vaccine mandates could potentially cut even more police and first-responders from the streets
- President Biden: "Yeah, fuck 'em."
Get out of the cities. Seriously.

For more detail:

Spoiler: video detailing the situation regarding police and mandates

Mind you, it's not so much that I'm a bleeding heart for the cops. I find the schadenfraude almost hysterical that the same cops which were kneeling en masse for George Floyd as cities burned and were arresting pastors for leading a prayer group in public (despite distancing and masks and being in open air) are now antsy about coming under fire like this. However, what's not funny is how the idiots in charge seem to want to destroy the entire country because muh vax mandates. We already have two instances this year of daylight rapes in public transit. Do we really want to see what this country will look like with 1/3 of its first-responders and cops laid off?

tl;dr GET THE HELL OUT OF THE CITIES

Now now, you can't say the vaccine will fail until we start giving it, just the same as not knowing if it's safe for kids age

"You never know until you try" isn't the motto of medical science. It's the motto of a children's book. Are we sure these boomers aren't all reaching the age of senility?

 

[uncleShitHeel]

Both enraging and horrifying.

It's extraordinary isn't it. I genuinely couldn't understand how totalitarian regimes were able to get away with the shit they did, until the last 10 months.

However it goes to show that even smaller countries are willing to enforce mass house arrest on its own citizens, unsurprising considering what we've seen from Australia.

At least our genius govt has realised they can no longer afford to lock everyone in their houses for extended periods of time. I can almost guarantee that when we move Auckland out of lockdown we'll likely have calls to do it again from some of the most devoted branch covidians, but if the reports from a few weeks ago are correct they're planning on throwing their hands up, screaming 'fuck it' and seeing what happens vaccinated or not. Which is to say we'll probably get reamed just like the UK.

It sucks because I would prefer to just wait for Meissa's LAV if I must be forced to get it but the powers at be want to make us get jabbed NOW NOW NOW!!!

I understand your pain. I ended up being called by the Covid-19 vaccination folks yesterday (which must mean their list of dirty unvaxxed is far smaller than I thought, as they asked for me by name), they were pretty polite about the whole thing and the lady on the phone was understanding enough when I told her I agree with vaccines in general but I have serious fucking reservations about being coerced into taking experimental medical tech.

She mentioned that I'd want to speak to my doctor and contact the Ministry of Health directly in order to speak about alternatives, so I'll be pursuing both options over the next few days.

Her smug face really does say a lot here, doesn't it? And of course we have yet another government official disregarding the science in favor of mandate madness. It's a craze at this point.

Oh don't fret, our prime ministers have been like this since the late 90's. Probably even earlier. Actually probably even earlier.

At every pivotal point in her rule she has made decisions in favour of increasing the wealth of the boomers and the elderly at the expense of the rest of us and has generally pushed divisive viewpoints and policy.

At this point as one of the dirty un-vaccinated I'm not allowed to go to the gym or bars or restaurants or hairdressers, at some nebulous point in the future. Which would bother me more if I assumed that the vax passport wasn't going to be poorly cobbled together piece of shit, that this wasn't a bluff to scare the remaining normies into absolute compliance (if legally challenged on their contradictory bs the govt generally makes concessions. Especially if the population is obviously pissed off, they've already walked back their mandates on health care by at least a fortnight as of last week). Finally if this wasn't a little repeat of a decade ago when I was in Christchurch.

Plus I'm extremely curious to see how she'll handle the upcoming economic crisis. Because I don't see much of the country bothering with compliance when we're up to our eyeballs in debt, the housing market finally tanks and endless boosters are being rolled out as we're being blackmailed in order to get our civil liberties back.

Although the last 13+ years have provided me with enough material for a game I like to call: 'How will this fuckwit outdo Muldoon today?' (For context Robert Muldoon was PM during the late 70's & early 80's. His economic mis-management was legendary and he's in/famous for getting absolutely shitfaced and calling a surprise snap election live on TV - which he predictably lost).

More lockdowns, more mask bullshit, more attacking people who question the increasing schizophrenia coming out from our "experts" and "institutions". More transfer of wealth from the not giga-rich to the giga-rich. Further implementation of social control. Further regimenting and training of mindless retards that imbibe every contradictory thing put out from our "betters". More shit like vaccine subscriptions. Further isolation of people that dare to not go along with it all.

I can't see this lasting forever though. With the global economy quickly approaching a cliff, I do not see most governments being able to maintain this shit. Anyone who continues on with this idiocy deserves what they get though.

Edit: forgot to mention. A hikoi managed to breach blockade through Auckland and make to Waitangi for a Hui today. Pretty fucking impressive.

 

[BLEACHED.COM]

What's the point if this nigger chink virus keeps mutating?

To make money by selling vaccines.

 

[SCSI]

Catching up on the thread, and I come bearing archives.

MAJOR update incoming (although it's from a month+ ago). Need to parse through some of this info but I want to share it in the thread first. Essentially this is a direct follow-up to the "Vaccines Kill More than They Save?" section of the OP, and this time there's plenty of receipts to sort through if people want to prove/disprove it.

View attachment 2632514

Sorry for the poor quality, I used OBS since I didn't find this on youtube for download and then converted it with VLC. It's long but worth listening to; the above is a video, heavily edited by me for time, of Steve Kirsch, head of the Early Covid-19 Research Fund and voice behind those clips in the OP taken from the FDA livestream. He sorta sounds like a negative universe Bill Gates. Anyway, after considering him and that article which brought into question his character and information, I came across an article which linked back to the above video, itself citing many sources taken from his presentation (which can all be found on his website apparently). The article he wrote recently was published on Trial Site News called "Proof the CDC is Lying to the World About Covid Vaccine Safety".
The article links:

Proof that the CDC is lying to the world about COVID vaccine safety

Note that views expressed in this opinion article are the writer’s personal views and not necessarily those of TrialSite. The CDC and the FDA claim that

trialsitenews.com

https://archive.md/ubBOB

The full video: https://rumble.com/vn3y22-tfnt9-cdc...-members-should-resign-for-failing-to-sp.html

<snip>

A bit late here, but it's worth the wait, I promise -- I was able to rip the full video of this off of Rumble with yt-dlp and get it crunched down small enough to fit without losing quality. This archive is also the full 54 minutes, it looks like your OBS capture lost the second half of the presentation.

View attachment 2641336
I have not heard about THIS vaccine.

Interesting. Looks like PBS ran a longer segment on this booster recommendation for the J&J vaccine than Yahoo did, so I grabbed that one instead.

<snip>
So firstly, I can't read the whole article since archiving it just links back to what I assume is a previous iteration (see: Left). This more recent article is paywalled. It's also the one that directly addresses the main concern of every functional human being about vaccinating 5yr olds: heart inflammation?
From the two introductory lines I could copy-paste, it seems like the FDA says, quote: "[the FDA] flagged the risk of heart-inflammation conditions including myocarditis associated with the vaccine, but the overall benefits, in preventing Covid-19 disease and hospitalizations, would outweigh the risk of the heart inflammation."
<snip>

I wasn't able to find a good workaround for this shitty paywall, but I did notice a very similar article up for free on WSJ's sister site, MarketWatch, and I was able to archive that. (Archive)

Snippets:

The final regulatory stamp of approval has to come from the Centers for Disease Control and Prevention’s Advisory Committee on Immunization Practices, which is set to meet next Tuesday and Wednesday, and the CDC director herself.

The proposed authorization for elementary school-aged children is different than the one granted for teens and adults. This formulation is also a two-dose vaccine, but the dosage is much smaller, at 10 micrograms dose administered 21 days apart. The regimen for individuals who are at least 12 years old who get the BioNTech/Pfizer vaccine is two 30-microgram doses 21 days apart.

Even with committee members all in favor of the FDA authorizing the vaccine for young children, the discussion on Tuesday raised questions about implementing a uniform policy for vaccinating this age group. Some clinicians urged the FDA to think about making a more flexible authorization that could take into account different dosing regimens.

Committee members also asked about safety risks for younger children, including the risk of myocarditis, a type of inflammation of the heart.

This is a very rare but documented side effect that has occurred after a small number of people have received the second shot of the mRNA vaccines developed by BioNTech/Pfizer and Moderna Inc.

Speaking of the Oct. 26 FDA "Vaccines and Related Biological Products Advisory Committee" hearing that covered this 17-0 vote, I've gone ahead and pulled the whole 8 hour thing down from Youtube. If anyone has timestamps of juicy stuff worth archiving from this, let me know and I'll chop them out and post. If the entire thing is important, I can split and compress it like I did the September 17th one before, but if it's mostly filler I'd rather go with a more targeted approach that doesn't require trying to forcefeed a gigabyte of video onto the servers here with how erratic performance has been.

 

[Major Discord]

Those God-damn low-IQ anti-vaxxers! Why can't they just educate themselves and trust the science?
https://www.techstartups.com/2021/10/19/top-100-nuclear-scientists-highest-security-clearances-fired-los-alamos-lab-due-vaccine-mandate/

 

[Fanatical Pragmatist]

Those God-damn low-IQ anti-vaxxers! Why can't they just educate themselves and trust the science?
https://www.techstartups.com/2021/10/19/top-100-nuclear-scientists-highest-security-clearances-fired-los-alamos-lab-due-vaccine-mandate/

I was thinking about the parabola where the least educated and most educated are the most vaccine hesitant, while people with Bachelor's & Master's are the most vaccinated.

I am betting an element has to do with replaceability and ability to find another position. The high-school graduate who has always only been working wagie jobs can just find another wagie job should his company mandate the vax, while the fucking nuclear engineer can probably afford to find work somewhere else that will be willing to hire a fucking nuclear engineer.
On the other hand, the people with good education and specialized work experience, but not enough to the point of being exceptionally highly educated and/or with niche experience find themselves in a position where they are still replaceable by over two-score willing successors but with limited options of where else they could go to work for.

 

[Hollywood Hulk Hogan]

I was thinking about the parabola where the least educated and most educated are the most vaccine hesitant, while people with Bachelor's & Master's are the most vaccinated.

Lol gonna need a citation on this one. So why are you willing to lose your Petco job over a simple vaccine? Why are you so afraid of a little jab? Serious question... you claim to not be a conspiracy nut, so answer me what you're afraid of from this vaccine.

I am betting an element has to do with replaceability and ability to find another position. The high-school graduate who has always only been working wagie jobs can just find another wagie job should his company mandate the vax, while the fucking nuclear engineer can probably afford to find work somewhere else that will be willing to hire a fucking nuclear engineer.
On the other hand, the people with good education and specialized work experience, but not enough to the point of being exceptionally highly educated and/or with niche experience find themselves in a position where they are still replaceable by over two-score willing successors but with limited options of where else they could go to work for.

It's because you just pulled that out of your ass and are now coming up with some explanation for the thing you completely made up

 

[DaBigBopper]

I was thinking about the parabola where the least educated and most educated are the most vaccine hesitant, while people with Bachelor's & Master's are the most vaccinated.

I am betting an element has to do with replaceability and ability to find another position. The high-school graduate who has always only been working wagie jobs can just find another wagie job should his company mandate the vax, while the fucking nuclear engineer can probably afford to find work somewhere else that will be willing to hire a fucking nuclear engineer.
On the other hand, the people with good education and specialized work experience, but not enough to the point of being exceptionally highly educated and/or with niche experience find themselves in a position where they are still replaceable by over two-score willing successors but with limited options of where else they could go to work for.

I wouldn't really say it's educated, I'd say it's more experience with the middle managers and people who cut the check for research. You ever meet someone who's in charge solely because they brown nose well enough? People who fund a lot of research and fund national labs are not the smartest people, I've had to sit through more than a few conferences where the people getting the most interaction are people who wildly mischaracterize their research, mostly biologists. Physics and Chemistry are usually more product oriented, you make something that might make you money because it's novel, or you develop a pathway to synthesize something cheaper or at better quantities. Biology from what I've seen is always kinda delusional, or to be more polite it's a lot of hoping for the best. You could program baby stem cells to grow new arms and legs or they could just be mostly worthless outside of the conditions of the womb and a lot of that lobbying was just stuffing cash into peoples pockets.

Nuclear Engineers are probably going to probably be a lot more skeptical of magical solutions to problems considering how Green Energy is a giant fucking scam and has been pushed for the last half century as a panacea to the problems ailing our world. The Covid Vaccine is similar, I can't wait until the Covid Vaccine will also stop racism like Green Energy will. I think Nuclear Engineers were also the ones protesting CRT being pushed at their plants because it just fucks with morale because it's something like 90% whites and asians with the only people of color in admin.

 

[EyelessMC]

I forgot who posted this or who sent it but I wanted to get the pic posted in the thread before I head off for a while:

I think Nuclear Engineers were also the ones protesting CRT being pushed at their plants because it just fucks with morale because it's something like 90% whites and asians with the only people of color in admin.

Spoiler: a brief aside

Wouldn't be surprising. Democrats have been pushing that retardation into every facet of society for a little while now, especially in schools and jobs which are seen as white collar. However everything this current political party is doing is pissing everyone off on all sides, it seems, even those who otherwise would be staunch Dems. Despite what the media portrays, there is a unifying factor amid all the division of race, vax, etc. and it's disdain for Biden & Friends. It's like the Bush era Republicans passed the baton. In less than a year they've managed to screw the country over and anger everyone faster than the last three presidents combined. Should give them a medal.

None of this would be as severe, or even possible, if not for the protracted obsession with Covid vaccination either. All the hemorrhaging spending, all the inflation, all the distribution problems, the rise in crime, the steadily rising unemployment, the bolstering of the IRS's scope, shortage on medical personnel and police, etc. The list just goes on. It's not even the vaccine themselves to blame on this one but the "people" (term used loosely) instituting the mandates.

 

[Fanatical Pragmatist]

I wouldn't really say it's educated, I'd say it's more experience with the middle managers and people who cut the check for research. You ever meet someone who's in charge solely because they brown nose well enough?

I guess my point had less to do with education on its own and more to do with how hard it is for your employer to find a replacement and how easy it is for you to find another job up to your standards.

This is the education level curve I was referring to, however. I believe it was posted >10 pages back or so:

My thought is that it might have less to do with education, and more to do with greater "fuck you" power. HS or less can always find one of hundreds of low-wage unskilled or partly-skilled jobs, PhD's can either tell their employers to fuck off (or are the employer sometimes), while bachelors & masters have less options unless they want to bump down and do wagie stuff.

People who fund a lot of research and fund national labs are not the smartest people, I've had to sit through more than a few conferences where the people getting the most interaction are people who wildly mischaracterize their research, mostly biologists. Physics and Chemistry are usually more product oriented, you make something that might make you money because it's novel, or you develop a pathway to synthesize something cheaper or at better quantities. Biology from what I've seen is always kinda delusional, or to be more polite it's a lot of hoping for the best. You could program baby stem cells to grow new arms and legs or they could just be mostly worthless outside of the conditions of the womb and a lot of that lobbying was just stuffing cash into peoples pockets.

I'm not going to lie, half the time you have to wildly mischaracterize shit just to get funding. Especially so if you are talking field-side biology, because shitty humans have this notion that only species which provide some benefit to us should be subjects of research and ultimately conservation. Multiply this to the fourth power if the species you want to study/save might *gasp* pose some danger to people.
Now there is a chance that the purses might see right through your wild claims and optimistic links, but considering you otherwise wouldn't get funding in most cases, its worth the risk.

I was told by a professor in college that you can get any research funded if you tie it in to any possible tedious link to cancer cures/treatments.

 

[Mr Bunny]

if you tie it in to any possible tedious link to cancer cures/treatments.

And climate change