Wuhan Coronavirus / COVID-19 Thread 2: Booster Shot - Resume all Corona sperging here.

[Lichen Bark]

Hey you know how I always say "I'm waiting to see if the vaccines will cause cancer or something," about that....

https://phmpt.org/wp-content/uploads/2022/03/125742_S1_M2_24_nonclinical-overview.pdf page 29
They weren't required to do any studies to see if they did, just let that sink in. This is a novel product, and they weren't required to do them. Thanks to these court ordered documents we now know this. I'm at a loss for words.

I can't even.

 

[Drain Todger]

I can go into more detail about parts of this at least. There are several parts to mRNA. The two that are brought up here are basically the coding sequence (CDS) and the 3' untranslated region (3'UTR). The CDS is what is used to make the protein, and the 3' UTR is not used to make the protein but instead is meant to regulate the stability of the mRNA and regulate how much protein is made. There is another class of RNAs I have to mention as well: non-coding RNAs (ncRNAs). These are RNAs that do not make protein, but rather the RNA itself performs some sort of function. So it sounds like for AES they took the 3' UTR (which normally shouldn't make protein) and put it after the stop codon for the spike protein. As long as they didn't fuck it up, there shouldn't be a risk of the AES 3'UTR specifically fucking anything up. But it gets a lot more complex.

mtRNR-1 is one of those ncRNAs, specifically a type known as a ribosomal RNA (rRNA). Like I said, it has functions itself. This seems to me like a terrible idea to put into a mRNA. The big question I have is how much of the mtRNR-1 gene is in the sequence (based on the paper it sounds like 142 of the 959 nt, though the more important question is which nucleotides)? The mutations in this ncRNA actually change its structure and function, and it looks like that is how the mutations cause hearing loss (disclaimer, I can't read this whole article now for info beyond the abstract. If anyone wants I can try and get access later).So it sounds like Pfizer took some part of a ncRNA that can cause issues when mutated/modified, and threw it in with the spike protein sequence, not knowing how the spike protein sequence would affect the ncRNA sequence. This means that the mRNA itself may (emphasis on may) be dangerous. Could this result in the deafness? Possibly, though that would need research to be done. With the dangers of the spike protein and the reports of autoimmune disorders, I would honestly lean more towards the spike protein and immune response fucking up their hearing instead. But I can't believe that they wouldn't see an issue with putting ncRNA sequences into an experimental drug (or more likely they just ignored the potential issue).

Lastly I'll mention the pseudouridine. As a side note with the last paragraph, inserting pseudouridines can influence not only RNA stability, but RNA structure, which is again something you have to be incredibly careful about when working with a ncRNA, especially one where changes in structure result in pathologies. As for what is said in the post, it looks wells supported that pseudouridine results in stop codon readthrough in yeast. My understanding is that they did not insert the pseudouridine at designated locations, and instead if they inserted it randomly into a stop codon then a bunch of extra junk may get turned into protein (though it is also very possible that the ribosomes could recognize something is wrong and abort making the protein altogether. It's impossible to say without knowing the sequence in question, which is why it's important to test these things). If that is the case, I would hazard a guess that we have little to no idea what would get made. Neither the 3' UTR of AES or any of mtRNR-1 are meant to be made into proteins. So you wouldn't really end up with spike+AES+MTRNR1, but rather spike+junk+junk, with the junk maybe being harmless or maybe being dangerous, we wouldn't have any idea without knowing what the junk is and studying what effects it had.

As for pseudoruridine, cytochrome c, and mitochondria, what you just posted is an excellent explanation and I don't think I need to make things more confusing by trying to overexplain it. Everything I just wrote is probably too much for a lot of people anyways though I'm happy to answer questions. It really seems like all bets are off for what these shots can do to people.

Pseudouridylation also makes RNA resistant to breakdown by nucleases.

The Critical Contribution of Pseudouridine to mRNA COVID-19 Vaccines

The current COVID-19 pandemic is a massive source of global disruption, having led so far to two hundred and fifty million COVID-19 cases and almost five million deaths worldwide. It was recognized in the beginning that only an effective vaccine could lead to a way out of the pandemic, and...

www.frontiersin.org

Ψ was the first modified ribonucleotide discovered 7 decades ago (Cohn and Volkin, 1951; Davis and Allen, 1957), and it has been found in tRNA, rRNA, snRNA, mRNA, and other types of RNA (Carlile et al., 2014; Lovejoy et al., 2014; Schwartz et al., 2014). Ψ is derived from uridine via a base-specific isomerization reaction called pseudouridylation (Figure 1), in which the nucleobase rotates 180° around the N3-C6 axis, resulting in the change of nucleobase-sugar bond (from N1-C1′ bond to C5-C1′ bond). The resulting C-C bond allows the nucleobase to rotate more freely (Adachi et al., 2021). In addition, Ψ can provide an extra hydrogen bond donor (in the N1H) in the major groove while keeping the hydrogen bond donor and acceptor (same as in its original uridine) in the Watson-Crick face. While the changes seem subtle (in fact, Ψ can base-pair with adenosine just as uridine does), Ψ can alter RNA structure in a relatively significant way, mainly by improving base-pairing, base stacking, and contributing to making the backbone more rigid (through a network of hydrogen bonding interactions) (Davis, 1995; Charette and Gray, 2000; Newby and Greenbaum, 2001, 2002a, 2002b). As such, RNA pseudouridylation generally stabilizes the RNA. Thus, it is not surprising that the presence of this RNA modification confers distinct biophysical and biochemical properties to the RNA. For example, Ψ favors a C3′-endo conformation in the RNA (Kierzek et al., 2014; Westhof, 2019). Further, it seems that Ψ increases the protection of the RNA against nucleases. A study from Naylor et al. showed that Ψ-containing dinucleotides were more resistant to degradation from snake venom and spleen phosphodiesterases, than the U-containing counterparts (Naylor et al., 1965).

They also claim that it bypasses TLR surveillance:

Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification and the Evolutionary Origin of RNA

DNA and RNA stimulate the mammalian innate immune system through activation of Toll-like receptors (TLRs). DNA containing methylated CpG motifs, however, is not stimulatory. Selected nucleosides in naturally occurring RNA are also methylated or otherwise modified, but the immunomodulatory...

www.cell.com

Distinct TLRs responded differently to RNA containing different modified nucleosides. RNA with m6A and s2U modifications did not activate TLR3, and those with m5C, m5U, s2U, m6A, or Ψ did not activate TLR7 or TLR8, whereas unmodified RNA could activate all these human TLRs. Finally, we show that RNA-mediated immune stimulation is suppressed proportionally with the number of modified nucleosides present in RNA and that even a few modifications are sufficient to exert a suppressive effect.

What shocks me the most about this is that they don't really seem to have investigated whether or not nucleoside-modified RNAs merely avoid binding and activate TLRs, or if they instead act as TLR blockers.

They could have tested this by exposing cells to nucleoside-modified mRNA and then exposing them to TLR agonists to see if there was a response in the form of cytokines, but they didn't.

https://www.medrxiv.org/content/10.1101/2021.05.03.21256520v1

Interestingly, we observed important heterologous effects of BNT162b2 vaccination on IFN-γ production induced by other stimuli as well (Figures S2E, 2F). BNT162b2 vaccination decreased 162 IFN-γ production upon stimulation with the TLR7/8 agonist R848 (Figure S2F).

Holy fuck. I don't think people realize how bad this is. TLRs are the body's smoke alarms. They're very important for detecting and responding to all sorts of cellular damage and cancers.

Toll-like receptor - Wikipedia

en.wikipedia.org

The Role of TLRs in Anti-cancer Immunity and Tumor Rejection

In recent years, a lot of scientific interest has focused on cancer immunotherapy. Although chronic inflammation has been described as one of the hallmarks of cancer, acute inflammation can actually trigger the immune system to fight diseases, including cancer. Toll-like receptor (TLR) ligands...

www.frontiersin.org

How long do nucleoside-modified mRNA strands persist in the body? How do they affect TLR expression and function? We don't know.

"We're never going to learn about how safe the vaccine is unless we start giving it. That's just the way it goes." -Dr. Eric Rubin

 

[Hollywood Hitler]

I was scrolling through Spotify to see what guests Joe Rogan has had on recently, and every episode had this blue banner saying "Click here for more COVID-19 information."

IDK about you, but it seems redundant since everybody knows the narrative by now, and by continuing to interject the narrative into everything just shows how much of a lie it is.

I'm really sick of these liars who continue to lie even after their lie has been exposed. The CDC, Fauci, and the rest of these faggots are pretty much screaming about Y2K in the year 2007 at this point.

 

[ZazietheBeast]

The real issue is going to be dealing with the aftermath of all of this. I know sheep are gonna sheep.

Vaxxcattle have proven themselves to be self-indoctrinating sheep who will be more than willing to walk into the slaughterhouse with a smile on their face.

And unfortunately, even if the Vaxx is the cause of heart problems compounded with cancer, within 5 or less years, many will simply forget about the needle they took from the group of people they thought were watching out for them.

Also, a helpful note about cancer. Stage 3 and Stage 4 are treatable. Its a matter of finding a clinic that can pull it off. And unfortunately, the US medical system is a sham so you'll have to find other means.

https://youtu.be/hsRVQWfqjms?t=4218 - A video about cancer immunology made by Sseth. Yes, that Sseth.

 

[Protistology]

The real issue is going to be dealing with the aftermath of all of this. I know sheep are gonna sheep.

Vaxxcattle have proven themselves to be self-indoctrinating sheep who will be more than willing to walk into the slaughterhouse with a smile on their face.

And unfortunately, even if the Vaxx is the cause of heart problems compounded with cancer, within 5 or less years, many will simply forget about the needle they took from the group of people they thought were watching out for them.

Also, a helpful note about cancer. Stage 3 and Stage 4 are treatable. Its a matter of finding a clinic that can pull it off. And unfortunately, the US medical system is a sham so you'll have to find other means.

https://youtu.be/hsRVQWfqjms?t=4218 - A video about cancer immunology made by Sseth. Yes, that Sseth.

Have you heard theories that Ivermectin helps with ccancer? lol.

 

[Grant McClellan]

Some places were never in lockdown even before the "vaccines." It's over mate. Jabbed or not, sensible people are going on with their lives after realizing what a farce the whole thing has been.

You

I was scrolling through Spotify to see what guests Joe Rogan has had on recently, and every episode had this blue banner saying "Click here for more COVID-19 information."

IDK about you, but it seems redundant since everybody knows the narrative by now, and by continuing to interject the narrative into everything just shows how much of a lie it is.

I'm really sick of these liars who continue to lie even after their lie has been exposed. The CDC, Fauci, and the rest of these faggots are pretty much screaming about Y2K in the year 2007 at this point.

What lies?, Rogan keeps going on about Ivermectin which we know is useless against Covid

It really is the most amazingly awful vaccine of all time. I'm still shocked at just how dumb people are to have been conditioned into accepting it was never meant to prevent transmission or infection when there would be no way of it breaking the pandemic in that case. If the measles or mumps vaccines had worked that way we would have seen people going to school covered in spots and saying they are fine.

That never happened. It just point blank never happened. Previous vaccines at least had a noticeable effect on breaking out in recognizable illness. It's not like you get a bit of rabies with the rabies vaccine. Break through cases in that circumstance were actually rare. If ones were occurring that didn't show symptoms, we would not have recognized them as a true infection back then, which is the dumbest change in our understanding of disease that covid has brought about, but there are tons of fully symptomatic "breakthrough" infections so that's still moot. The jab is shit at doing what it set out to do. It does not break the transmission cycle and hopefully it's actually so useless that it doesn't even challenge covid in the body at all and that's all that's saved us from having it drive up the virulence of covid as was seen in Merek's disease.

At least the flu shots are all for different species of virus that we just put under the banner of flu. They actually work a bit if the science guessed the right strain in the lottery that year, the problem being it changes so much and there are thousands of species so they are more likely to be wrong than not. It's a bit like winning the Numbers Game lottery, but if H1Whatever was the strain that year and you were old, maybe it would have some marginal benefit due to cross immunity. It's also a pretty stupid thing to vaccinate against, but if you are a hypochondriac and want it, you do you.

My covidian friends are also super excited that Moderna is going to make a shot against even the basic ass cold now. You know what? I'm going to embrace colds. I think it's like weightlifting. Sometimes I want my body to use its functionality in a relatively safe environment. I don't even think I want a cancer shot at this point. I'm just ready to embrace mortality and face whatever time I get. It's better than the alternative of hopping up on constant treatments to try and deny biology.

You are a fucking idiot. The vaccines have worked, are safe and effective and have prevented lockdowns from happening again (with the exception of Shanghai). I'm vaccinated and proud of it. Get the vaccine already

 

[Big Brown Schlub]

And unfortunately, even if the Vaxx is the cause of heart problems compounded with cancer, within 5 or less years, many will simply forget about the needle they took from the group of people they thought were watching out for them.

Given that TPTB are still handling this like retards I doubt it, if they actually started winding the 'rona hysteria down I'd believe it but it's clear as day that in most countries we're just seeing a calm before the storm. They'll let the sheep regrow their wool in the spring and summer before the shearing restarts in fall this year. Due to their willingness in making the plandemic last seemingly for decades all the while expecting the cattle to receive never ending yearly biyearly quarterly monthly biweekly weekly daily hourly minutely secondly boosters, this will always be in people's minds. I get it, there's always gonna be true believers who will never link their exciting new cancers/heart problems/AIDS to their Holy Sacrament, but their numbers are going down day by day not to mention that it seems like most people took it because they were essentially blackmailed into taking it and they sure as shit will connect weird health problems to their experimental gene therapy.

 

[Drain Todger]

Listen to this podcast, featuring Ralph Baric and dated to 2015, where he discusses his work on that infamous 2015 SARS paper:

TWiV 364: It's not SARS 2.0 | This Week in Virology

Vincent, Rich, and Kathy speak with Ralph and Vineet about their research on the potential of SARS-like bat coronaviruses to infect human cells and cause disease in mice.

www.microbe.tv

 

[Sanshain]

You

You are a fucking idiot. The vaccines have worked, are safe and effective and have prevented lockdowns from happening again (with the exception of Shanghai). I'm vaccinated and proud of it. Get the vaccine already

Did the vaccine make you forget how to use the keyboard, or had you forgotten how to use that already, cattle?

 

[Fliddaroonie]

You

What lies?, Rogan keeps going on about Ivermectin which we know is useless against Covid


You are a fucking idiot. The vaccines have worked, are safe and effective and have prevented lockdowns from happening again (with the exception of Shanghai). I'm vaccinated and proud of it. Get the vaccine already

Oi, Granty Goblin fatboy. You're very selective about who you reply to. It's almost like you're a spineless cucked little boy, who likes easy marks only.

Typical fucking Scot, especially a Glaswegian. Talks a good game, runs his fat, snaggle toothed mouth, but completely fucking useless and unable to deliver.

You had a shitty week in your retail job or something? Bad time? Boss being mean, customers taking it out on you?

So here you are back on the Farms, flailing like a spastic, picking fights you know you can't win. Which is odd because you talk a good deal on Twatter about "I'm going to make positive changes!!" "I hope the people who care about me know I'm making positive steps!!". How? By coming on here and trying to engage in bad faith arguments with people who you know disagree with you?
Were you dropped as an infant, or are the SNP intentionally raising fucking spastics?


Edited to say: Grant, why are you sending me messages telling me "fuck you. That's all"? Too much of a pussy to say it publicly?

 

[GuitarRevi]

or are the SNP intentionally raising fucking spastics?

yes

 

[Hollywood Hitler]

You

What lies?, Rogan keeps going on about Ivermectin which we know is useless against Covid


You are a fucking idiot. The vaccines have worked, are safe and effective and have prevented lockdowns from happening again (with the exception of Shanghai). I'm vaccinated and proud of it. Get the vaccine already

Did you eat paint chips as a child?

 

[Super-Chevy454]

There's a Brazilian journalist who wasn't lucky as Rafael Silva unfortunately...

42-Year-Old Brazilian Journalist Dies After Heart Attack

Jocelito Paganelli, the Brazilian Journalist and editor-in-chief of TV TEM, an affiliate of Globo in São José do Rio Preto (SP), died on March 29th, 2022. The journalist passed away at 42 years of age. He reportedly suffered a heart attack inside his home and emergency services were unable to...

welovetrump.com

Jocelito Paganelli, the Brazilian Journalist and editor-in-chief of TV TEM, an affiliate of Globo in São José do Rio Preto (SP), died on March 29th, 2022.

The journalist passed away at 42 years of age.

He reportedly suffered a heart attack inside his home and emergency services were unable to revive him.

 

[Abdul Alhazred]

You

What lies?, Rogan keeps going on about Ivermectin which we know is useless against Covid


You are a fucking idiot. The vaccines have worked, are safe and effective and have prevented lockdowns from happening again (with the exception of Shanghai). I'm vaccinated and proud of it. Get the vaccine already

So somehow the same vaccine that is 100% safe and effective needs literally the entire Earth's human population to take it otherwise it doesn't work

 

[Fliddaroonie]

So somehow the same vaccine that is 100% safe and effective needs literally the entire Earth's human population to take it otherwise it doesn't work

Safe And effective!!! SAFE AND EFFECTIVE!!!????!!!!!!!!!!

 

[HarblMcDavid]

DAE we need to throw the whole empire in the trash because it doesn't muzzle us hard enough? Me big brain.

View attachment 3134359

Someone hold their dick up for them we got people namedropping Socrates!

Also known as "how to tell people you have more education than the sheep brain can handle, in less than 4 tweets".

Nice find.

 

[Simpadoo]

That SOB Dr. Fraudci, found some excuses to not go to covid hearings.

Dr. Fauci's Excuse for Skipping Covid Hearing Will Infuriate Americans

Subscribe on Rumble: https://rumble.com/user/KYLENBECKER Follow on Telegram: https://t.me/beckernews Follow on Twitter: https://twitter.com/kylenabecker Follow on Facebook: https://www.facebook.com/ky

rumble.com

Edit: However Fauxci have some time to be interviewed by foreign medias.

https://twitter.com/YWNReporter/status/1508910208520757252

He had to attend the Nurgle jubilee and couldn’t manage the scheduling conflict. Priorities.

 

[Getting tard comed]

https://freewestmedia.com/2022/04/02/tennis-world-shocked-after-scores-of-players-drop-out-of-miami-open/

We don't know it's the vaxx... but it's the vaxx.

 

[Grant McClellan]

Did the vaccine make you forget how to use the keyboard, or had you forgotten how to use that already, cattle?

I am far from the sheep you think i am. I don't follow misinformation merchants like Tucker Carlson,

https://freewestmedia.com/2022/04/02/tennis-world-shocked-after-scores-of-players-drop-out-of-miami-open/

We don't know it's the vaxx... but it's the vaxx.

It's not the vax you stupid cunt

 

[borsabil]

https://freewestmedia.com/2022/04/02/tennis-world-shocked-after-scores-of-players-drop-out-of-miami-open/

We don't know it's the vaxx... but it's the vaxx.

There's an unprecedented amount absenteeism here in Aus. My boss told me last week that sick leave is 10 times higher than normal, the missus tells me it's the same in her work, 8-10 staff calling in sick day in day out. It's worse now than during the big Covid outbreak in January.