I don't follow the Opie & Anthony community, but yeah. There is a threshold that all long term alcoholics eventually cross where they need to be treated like vulnerable adults until their competency is restored following a period of enforced abstention. They often need assistance to bathe properly, need consistent reminders to chew food before swallowing, and so on, 0nlyUseMeBlade from the IP2 circus is someone fast approaching that stage.
Korsakoff is just one of many looming threats to Ralph's health, but just about any physician getting a glimpse at Ralph is probably going to be way more concerned about his heart and overall cardiovascular health. That pallor combined with labored breathing from just walking is fucking grim.
Alprazolam (xanax) is pretty synergistic with ethanol and the desirable effects of alprazolam can be extended by ethanol consumption, why that is really isn't understood, but I think it has something to do with the fact both substances are metabolized by the body differently. The aggression you mentioned is a common secondary effect, even in Pfizer's original clinical tests, people taking low dosages self reported anger issues. The two combined is just a recipe for violence IMO.
Watching Ralph's most recent fight with his inability to keep his balance and how delayed the response to protect his face with his hands/arms looks like cerebellar degeneration, which can be caused by both alcohol abuse and benzo abuse. Warski would have pummeled the shit out of him and those 14oz gloves would have had Ralph's brain sloshing around in that fat cranium of his, all to the further detriment of his cognitive health.
Ralph would have to fundamentally change his entire lifestyle to get clean, at this point streaming and using are so closely intertwined that he probably can't stream without triggering a craving of some kind.