Before watching the clip I really wanted to give him the benefit of the doubt. "Surely, he can't be that stupid" I thought. I was wrong. The way he said it comes across as being entirely serious, you can tell that he actually believes this. He's not doing that weird autistic snickering grin he does when he's just making a skit or trying to be funny. This is not a "you can't even tell a trans person from a real woman" gotcha moment, he 100% means what he is saying.
This is your brain on troonshine.