Not sure what I'd pick, but definitely not Las Vegas. Vegas is just kinda trashy and doesn't export globohomo influence all over the globe like the others. Agreeing with
@Rome's rightful successor that DC has too much history (both good and bad).
SF, while having pride as the Sodom of the world, doesn't have as much business and culture export influence like LA and NYC.
New York has all the globohomo woke media culture like SF and LA, but also finance, banking, and international politics/academia (UN, etc). You'd hit a little bit of everything TPTB use. NYC has no natural resources but a lot of history.
LA has Hollywood and Hollywood is pure evil. LA doesn't have a strong history or unique culture like the others, but it does have natural resource potential (oil, agriculture, and climate).
TLDR, it's between NYC and LA. My choice depends on if the ground/rubble can be used/rebuilt afterwards or if becomes a useless radioactive wasteland.