He's also sometimes said to be Sherlock Holmes but as a doctor.
Yeah there was supposed to be a Sherlock/Watson dynamic with Dr. House and Dr. Wilson, but the the Watson role was filled by House's team. There are still influences in the names (duh), drug addicted detective who doesnt take boring cases, inductive reasoning, etc.
The other big failure is that the "genius doctor" angle doesn't hold up. Nothing in the show ever convinces the viewer that House is any better than your standard run of the mill doctor. Even the investigative tactics he uses are apparently standard operating procedure, according to anyone I know who worked in medicine. And yet the show's whole conceit is he's special somehow.
Even if the medicine is accurate, they are definitely not standard, and it's definitely not how hospitals and patient care goes. I watched an episode with a physician once, he got the diagnosis 10 minutes into the episode (it was Hepatitis C). He didn't get the answer because he was some 1000 IQ super genius, but because the show spends a lot of time using exotic procedures when a simple blood panel would point you in the right direction.
The show was originally titled Chasing Zebras. House MD is an inversion of the old medical adage "When you hear hoof beats, think horses, not zebras". The phrase advises to consider what is common before what is exotic and rare. The show deliberately contradicts this, because a show about common diseases that could be addressed by a quick blood panel isn't that interesting (this is not necessarily a bad thing, I enjoy the show too). Also (thankfully), I think there are way fewer patients going into seizure or cardiac arrest every episode.
Logistically, the show is even more inaccurate. "Diagnostic Medicine" isn't a hospital department. A lot of the stuff that goes on (aside from the obvious stuff like breaking and entering a patients home) shouldn't be handled by House's team, let alone a physician. The team isn't performing and reading CT scans, those are handled by rad tech and radiologists. Same with blood work, pathology, nursing etc. This is understandable, given that I don't think the audience would enjoy cutting to a random tech or nurse, and i think it'd complicate the filming of the show.
I'm not one of those pedantic faggots like cinemasins who cites unrealism as their only criticism, I enjoy House MD as well, although my personal favorite is Scrubs.