I don't think it's just a matter of them being normie memes, though the burn out from overuse is absolutely true as well. There's some sort of effect of meme meeting reality that makes the meme unfunny. It's that sense of cringe when Biden on camera said 'Let's go Brandon." It can't really happen with things like pepe or wojak because those aren't based on a real person who can recreate the meme in reality, and thereby destroy it.
It's the same effect as when you have an inside joke with your friends about another person, and then that other person gets in on the joke. Suddenly, the joke becomes unfunny and is dropped entirely.
I'm sure someone has noticed this effect and put it into a fancier explanation with more academic language, but I think you'd be hard pressed to find a meme that has survived confrontation with or recreation by the subject of the meme.