The thing with guts is that they are really complex and we are still learning all the time. Many of the neurotransmitters found in the brain are also found in the gut, and we are still learning what that actually means for human health. What’s the interaction between brain and gut? We don’t really understand. The HUGE diversity of bacteria (and fungi and archaea) that live in our guts are also the focus of research and again, our knowledge of what that actually means for our health is in its infancy.
So you end up with genuine, tentative research findings being leapt upon by quacks. Take SIBO (small intestinal bacterial overgrowth) for example. This is A Thing in some, fairly rare clinical circumstances. It can only be diagnosed via jejunal aspirate. Quacks will do a breath test on you (which actually measures transit time) diagnose you with SIBO and flog you whatever snake oil they are peddling to cure it (herbs, antibiotics, weird diets etc.)
An overly permeable gut is A Thing, but again it’s jumped on by quacks and sold in a different, nonsensical, manner.
Ditto stuff like bacterial flora. This is clinically important for lots of things - some nasty gut infections that are antibiotic resistant can be cured by poop transplants (grim, but fascinating.) it’s highly possible gut flora is linked to predisposition to obesity, and maybe some other conditions but research is still in its infancy and anyone who is selling you a cure based on manipulating it is a scammer.
In the meantime it’s munchie heaven, because it’s invisible and poorly studied.
Jan has been editing videos for jaquie's account and just uploaded the first. It's some footage Judd shot of the house while Jaq was still alive in the hospital. Nothing too terribly interesting. She says she's going to upload a video of the funeral too. I wonder if Jan is going to try to start posting her own vids on jaq's account since that one has so many more subs.
Jan has been editing videos for jaquie's account and just uploaded the first. It's some footage Judd shot of the house while Jaq was still alive in the hospital. Nothing too terribly interesting. She says she's going to upload a video of the funeral too. I wonder if Jan is going to try to start posting her own vids on jaq's account since that one has so many more subs.
Jan is going to totally Single White Female Jaq and become to new munchie queen. She recorded the funeral? That's not surprising but kinda tacky. I'll be watching.
Hey everyone, it's a miracle! Kelly's hundreds of seizures a day that came on suddenly when she couldn't go to the ER to get attention for her eating disorder anymore have abated. Surely it had nothing to do with the fact that she wanted to go to a reunion at Rosewood, an ED clinic she attended in Arizona, a place where she could once again get attention for having had an eating disorder.
Ditto stuff like bacterial flora. This is clinically important for lots of things - some nasty gut infections that are antibiotic resistant can be cured by poop transplants (grim, but fascinating.) it’s highly possible gut flora is linked to predisposition to obesity, and maybe some other conditions but research is still in its infancy and anyone who is selling you a cure based on manipulating it is a scammer.
Anything dealing with the microbiome is like the promised land for alt-med practitioners because we understand so fucking little about it.
In situ microbiome engineering is very, very new experimental science. Alt-med dudes are just throwing random supplements at you to heal your leaky-ass gut that you probably don't even have.
The thing about intestinal hyperpermeability is that it doesn't seem to cause any problems. If you've ever cracked open a cadaver that's been on an aspirin regimen for decades then you know what their intestines look like but it's not like they immediately get the lupus or anything.
If you've ever cracked open a cadaver that's been on an aspirin regimen for decades then you know what their intestines look like but it's not like they immediately get the lupus or anything.
Man, every time I'm dead sure something is just a junk dx for people who don't like that getting old feels bad, I find out it's actually a thing. So it exists as a clinical finding in other disorders, but not the alternative medicine systemic disease that causes lupus and autism and is cured by woo?
Does the real deal carry a risk of major infection or anything? Just wondering since "leaky [organ]" sounds like a recipe for death to me.
the tl;dr is that Aspirin and NSAIDs will essentially stop your small intestine from producing mucus, which (for whatever reason) causes the cells in your small intestine to start shitting out cytokines like crazy, leading to chronic inflammation, mucosal lesions, ulcers, small bowel petechiae, a lot of your villi dying, etc. it's not good.
NSAIDs also cause diaphragm-like structures to form in your small intestine and that's fucking weird. I don't think anyone knows the mechanism behind why that happens. I've never seen aspirin do the same thing but I guess it would be plausible since they have a very similar mechanism of action in the intestine.
I think most gastroenterologists hate Bayer at this point.
Pharma-FDA wars and how they get away with not warning people OTC drugs are still fucking drugs and can still fucking kill you in really gruesome ways one of the most entertaining topics in medical history. Probably a lot less entertaining if you're a doctor tasked with cleaning up the aftermath of people thinking daily Naproxen is safe to take indefinitely as long as you stay at the recommended dose.
Back in 1975 the Lancet published an Op-Ed saying if Tylenol was subject to that era's standards of testing it would not be available OTC and possibly not have made it to market at all because of hepatotoxicity and recommended finding a safer alternative. This started a shitstorm that would go on for decades on whether or not the makers of Tylenol needed to warn people that they could die from taking it too much. Four years later the FDA was strongly recommended by an advisory panel to force McNeil Pharmaceuticals to add a warning about how exceeding the maximum dose will make your liver die so don't do that. McNeil tried to petition the FDA to rule against the warning saying, basically, "all those people whose livers died were trying to kill themselves anyway."
Meanwhile even without the warning, Bayer started using "tylenol will kill your liver" to sell Aspirin as a safe alternative and cut deeply into McNeil's profit margins (aspirin later went out with the wind because it causes Reye syndrome in children and adolescents and now they don't even recommend it for daily low-dose prophylaxis for heart patients anymore).
In the 80s the subject became headlines when an assistant to GHW Bush, Antonio Benedi, almost died from taking the recommended dose of extra-strength tylenol for a few days. It totally demolished his liver because he was a daily wine drinker. He spent days in a coma and required a liver and kidney transplant to survive.
McNeil tried to secretly develop a safer version of Tylenol, but realized if they actually created it, it would be an admission that their previous formula was, by contrast, not safe and could potentially open them up to lawsuits. So the safer compounds never made it past animal tests and McNeil continued to argue that it didn't need to do anything to warn people because the people who died wanted to die.
Then someone did a study on survival in tylenol overdose cases. Counterintuitively, people who took massive, suicidal doses had a much higher survival rate than people who took a few too many and had a glass of wine. This was because the suicide attempters/their families knew they fucked up so they were more likely to be seen by an ER and given the antidote in time. It nearly always works if given within 8 hours. But the habitual wine drinker who just took three instead of two for a headache had no idea why he felt like shit and was more likely to try to sleep it off. Finally in 2005 the FDA forced them to add the liver warning. Around the same time the FDA created a public service campaign warning people about "double dipping" by taking tylenol on top of something that already contained acetaminophen like some formulations of cold medicine or Alka-Seltzer. McNeil went absolutely bananas over this, way outspent the FDA on advertisements assuring people their product was safe (FDA budget for the campaign was about $20,000. McNeil spent $100 million to refute it), and to this day most people don't realize how dangerous "double dipping" these drugs is.
Also, keep your cats away because even licking a tablet can cause methemoglobinemia, an incredibly gruesome form of anemia where ferric (Fe3+) iron instead of ferrous (Fe2+) iron binds irreversibly to red blood cells and blocks oxygen from binding. This means oxygen can't circulate to tissues and they essentially suffocate while breathing. Luckily it's treatable with methylene blue which converts ferric iron back to ferrous iron if caught in time. Unluckily, because people don't recognize tylenol is dangerous and might have even administered it themselves for some reason, they don't see the connection between the "safe" pill and the kitty acting sluggish and wait until kitty is at death's door to seek help.
Back on topic, Munchies abuse NSAIDs to induce symptoms and either claim they didn't know the dangers/they had to exceed recommended doses because of their pain that those mean doctors wouldn't give them narcotics for or they try to lie about using them. Usually they're used to induce GI bleeding and ulceration in the hopes of getting a diagnosis like Ulcerative Colitis. This person managed to fake Common Variable Immunodeficiency (generally what munchies claim they have when they say they're immune compromised) along with crohn's and celiac by surreptitiously taking NSAIDs after telling his doctors he had stopped taking them and was fully in compliance with their treatment plan. He got IVIG, which takes something in the range of ten thousand plasma donations to create one dose and is life-saving for people with actual immune diseases, and is now a trendy thing all the munchies try to get because it's rare and expensive. Gastroenterology suspected he was still taking NSAIDs because of certain findings, and his family finally ratted him out when they found packets of ibuprofen and codeine hidden all over the place.
the tl;dr is that Aspirin and NSAIDs will essentially stop your small intestine from producing mucus, which (for whatever reason) causes the cells in your small intestine to start shitting out cytokines like crazy, leading to chronic inflammation, mucosal lesions, ulcers, small bowel petechiae, a lot of your villi dying, etc. it's not good.
NSAIDs also cause diaphragm-like structures to form in your small intestine and that's fucking weird. I don't think anyone knows the mechanism behind why that happens. I've never seen aspirin do the same thing but I guess it would be plausible since they have a very similar mechanism of action in the intestine.
Pharma-FDA wars and how they get away with not warning people OTC drugs are still fucking drugs and can still fucking kill you in really gruesome ways one of the most entertaining topics in medical history. Probably a lot less entertaining if you're a doctor tasked with cleaning up the aftermath of people thinking daily Naproxen is safe to take indefinitely as long as you stay at the recommended dose.
Back in 1975 the Lancet published an Op-Ed saying if Tylenol was subject to that era's standards of testing it would not be available OTC and possibly not have made it to market at all because of hepatotoxicity and recommended finding a safer alternative. This started a shitstorm that would go on for decades on whether or not the makers of Tylenol needed to warn people that they could die from taking it too much. Four years later the FDA was strongly recommended by an advisory panel to force McNeil Pharmaceuticals to add a warning about how exceeding the maximum dose will make your liver die so don't do that. McNeil tried to petition the FDA to rule against the warning saying, basically, "all those people whose livers died were trying to kill themselves anyway."
Meanwhile even without the warning, Bayer started using "tylenol will kill your liver" to sell Aspirin as a safe alternative and cut deeply into McNeil's profit margins (aspirin later went out with the wind because it causes Reye syndrome in children and adolescents and now they don't even recommend it for daily low-dose prophylaxis for heart patients anymore).
In the 80s the subject became headlines when an assistant to GHW Bush, Antonio Benedi, almost died from taking the recommended dose of extra-strength tylenol for a few days. It totally demolished his liver because he was a daily wine drinker. He spent days in a coma and required a liver and kidney transplant to survive.
McNeil tried to secretly develop a safer version of Tylenol, but realized if they actually created it, it would be an admission that their previous formula was, by contrast, not safe and could potentially open them up to lawsuits. So the safer compounds never made it past animal tests and McNeil continued to argue that it didn't need to do anything to warn people because the people who died wanted to die.
Then someone did a study on survival in tylenol overdose cases. Counterintuitively, people who took massive, suicidal doses had a much higher survival rate than people who took a few too many and had a glass of wine. This was because the suicide attempters/their families knew they fucked up so they were more likely to be seen by an ER and given the antidote in time. It nearly always works if given within 8 hours. But the habitual wine drinker who just took three instead of two for a headache had no idea why he felt like shit and was more likely to try to sleep it off. Finally in 2005 the FDA forced them to add the liver warning. Around the same time the FDA created a public service campaign warning people about "double dipping" by taking tylenol on top of something that already contained acetaminophen like some formulations of cold medicine or Alka-Seltzer. McNeil went absolutely bananas over this, way outspent the FDA on advertisements assuring people their product was safe (FDA budget for the campaign was about $20,000. McNeil spent $100 million to refute it), and to this day most people don't realize how dangerous "double dipping" these drugs is.
Also, keep your cats away because even licking a tablet can cause methemoglobinemia, an incredibly gruesome form of anemia where ferric (Fe3+) iron instead of ferrous (Fe2+) iron binds irreversibly to red blood cells and blocks oxygen from binding. This means oxygen can't circulate to tissues and they essentially suffocate while breathing. Luckily it's reversible with methylene blue if caught in time. Unluckily, because people don't recognize tylenol is dangerous and might have even administered it themselves for some reason, they don't see the connection between the "safe" pill and the kitty acting sluggish and wait until kitty is at death's door to seek help.
Back on topic, Munchies abuse NSAIDs to induce symptoms and either claim they didn't know the dangers/they had to exceed recommended doses because of their pain that those mean doctors wouldn't give them narcotics for or they try to lie about using them. Usually they're used to induce GI bleeding and ulceration in the hopes of getting a diagnosis like Ulcerative Colitis. This person managed to fake Common Variable Immunodeficiency (generally what munchies claim they have when they say they're immune compromised) along with crohn's and celiac by surreptitiously taking NSAIDs after telling his doctors he had stopped taking them and was fully in compliance with their treatment plan. He got IVIG, which takes something in the range of ten thousand plasma donations to create one dose and is life-saving for people with actual immune diseases, and is now a trendy thing all the munchies try to get because it's rare and expensive. Gastroenterology suspected he was still taking NSAIDs because of certain findings, and his family finally ratted him out when they found packets of ibuprofen and codeine hidden all over the place.
I think these are the most horrifying posts on this thread. I never new NSAIDS could cause all of that. I would've thought that doctors needed to disclose the associated risks with taking different drugs. Is this why Omeprazole (Losec) is prescribed with them?
I think these are the most horrifying posts on this thread. I never new NSAIDS could cause all of that. I would've thought that doctors needed to disclose the associated risks with taking different drugs. Is this why Omeprazole (Losec) is prescribed with them?
Tl;dr: PPIs help prevent upper GI problems associated with NSAIDs but increase the chances of developing lower GI problems associated with NSAIDs, and these lower GI problems are considerably harder to treat and more likely to kill you.
EDIT: just for total transparency and to further scare the shit out of people, acetaminophen/paracetamol is not an NSAID, it's an analgesic. It has only minimal anti-inflammatory properties and we don't really know how it works. NSAIDs inhibit COX enzyme activity outside of the central nervous system. Paracetamol does not. It might work by selectively inhibiting COX activity in the brain, or it might work because one of its metabolites inhibits reuptake of endogenous cannabinoid compounds (neurotransmitters your body naturally produces that bind to the same receptors marijuana sets off, because the human body is fucking ridiculous). Or both. Or neither. Who knows?
Tl;dr: PPIs help prevent upper GI problems associated with NSAIDs but increase the chances of developing lower GI problems associated with NSAIDs, and these lower GI problems are considerably harder to treat and more likely to kill you.
EDIT: just for total transparency and to further scare the shit out of people, acetaminophen/paracetamol is not an NSAID, it's an analgesic. It has only minimal anti-inflammatory properties and we don't really know how it works. NSAIDs inhibit COX enzyme activity outside of the central nervous system. Paracetamol does not. It might work by selectively inhibiting COX activity in the brain, or it might work because one of its metabolites inhibits reuptake of endogenous cannabinoid compounds (neurotransmitters your body naturally produces that bind to the same receptors marijuana sets off, because the human body is fucking ridiculous). Or both. Or neither. Who knows?
Well that explains why paracetamol does nothing for arthritis pain.
My own two cents on this, diet and exercise works far better than NSAIDS and painkillers for managing auto immune inflammation. It's a common complaint in RA groups that Doc's who say this are fat shaming.
Well that explains why paracetamol does nothing for arthritis pain.
My own two cents on this, diet and exercise works far better than NSAIDS and painkillers for managing auto immune inflammation. It's a common complaint in RA groups that Doc's who say this are fat shaming.
Many chronic illness patients would have improved QOL if they ate healthy food, drank more water, were more cautious with which and how much medication they took, and went for a brisk walk every day. Actually it's the first line of treatment in many of these munchie conditions. For example, POTS symptoms will generally be reduce or go away if you exercise, drink water, and eat a high sodium diet. If not, there's beta blockers. What you shouldn't do is ram a needle into your chest exposing yourself to all sorts of pathogens and sit in a wheelchair deconditioning yourself.
But alas, munchies gonna munch, spoonies gonna muh condishuns.
Jaquie's thread is locked so I hope this is okay to post here.
Jan's latest video. She has Jaquie, Judd and Harlow in the opening credits now. This may mean more videos relating to Jaquie from her. Judd brought Harlow out as a service dog. She's now besties with Jaquie's church 'friends'. Hilarious mother's day church song.
Jaquie's thread is locked so I hope this is okay to post here.
Jan's latest video. She has Jaquie, Judd and Harlow in the opening credits now. This may mean more videos relating to Jaquie from her. Judd brought Harlow out as a service dog. She's now besties with Jaquie's church 'friends'. Hilarious mother's day church song.
I think these are the most horrifying posts on this thread. I never new NSAIDS could cause all of that. I would've thought that doctors needed to disclose the associated risks with taking different drugs. Is this why Omeprazole (Losec) is prescribed with them?
Not really, there are a couple other drugs prescribed to patient who are on NSAIDs to reduce GI risks but none of them really work. The rate of GI complications for people on NSAIDs is like 75%.
Technically insufflated heroin is the safest drug ever for pain management assuming you're not being dumb with it, but we obviously can't prescribe that to patients. Because, well, patients get dumb with it.
Jaquie's thread is locked so I hope this is okay to post here.
Jan's latest video. She has Jaquie, Judd and Harlow in the opening credits now. This may mean more videos relating to Jaquie from her. Judd brought Harlow out as a service dog. She's now besties with Jaquie's church 'friends'. Hilarious mother's day church song.
Wow. This whackadoo is really something else. She's trying so hard to be Jaq and take over her life. It's creepy as fuck. Especially the way she calls Jaq's mom her mom...and has Jaq, Judd, and Harlow in her intro. And why the fuck did she keep calling Harlow "Harpo"? IIRC Har's nickname is Hippo (which I also found stupid). I did notice that Judd does not seem like he wants to be on camera. Seemed like Jan was making a conscious effort not to show his face, and there was quite a long pause before he answered when she spoke directly to him. At the end when he was on camera he looked fucking pissed. Judd and the mom seemed over Jaq's shit by the time she bit it. I wonder how long Judd and Jaq's mom will indulge this fuckery. Jan even stole Jaq's mannerism. She gave us the Jaquie fist pump, keep moving forward, and wave at the end. I'm gonna have way too much fun watching Jan's crazy ship sink.
On another note, I wonder if Judd hasn't returned to work yet. He has quite the beard growing, and most police departments have strict facial hair standards.
Just gonna add her here, but Amy Lee Fisher strikes me as definitely not a munchie. Oversharing, yeah, but legitimately ill.
Which makes me realize how much all these munchies here are full of shit. Example? Good luck draining a burger. And like partial gastroparesis the doctors are going to be seriously reluctant to give a NG tube let alone anything else cause reliance on a tube would make the condition progress. I think her case lasted a month before the NG accomplished nothing.
I think a big difference is how munchies jump to the biggest and most intrisive treatment they can get first whereas the first 10 doctors they see refuse to place a tube and tell them to alter their diets and the 11th places an NG tube. A not munchie obviously doesnt even get to that many doctors seeking a specific end result.
I do wonder if these munchies not following doctor directions creates gastrointestinal issues.
Edit: well, sounds like Ginger and the whole ED leads to actual health crap.
Just gonna add her here, but Amy Lee Fisher strikes me as definitely not a munchie. Oversharing, yeah, but legitimately ill.
Which makes me realize how much all these munchies here are full of shit. Example? Good luck draining a burger. And like partial gastroparesis the doctors are going to be seriously reluctant to give a NG tube let alone anything else cause reliance on a tube would make the condition progress. I think her case lasted a month before the NG accomplished nothing.
I think a big difference is how munchies jump to the biggest and most intrisive treatment they can get first whereas the first 10 doctors they see refuse to place a tube and tell them to alter their diets and the 11th places an NG tube. A not munchie obviously doesnt even get to that many doctors seeking a specific end result.
I do wonder if these munchies not following doctor directions creates gastrointestinal issues.
She’s is/was pro-ana basically and caused most of her issues from purging from her tube. She used to shop her self thinner and supposedly drains burgers herself. She’s definitely not one to champion.
she also got her surgical tube because her throwing up caused her ng to come up. She actually seemed to do ok on her ng.
My guess is her surgical tube made it easier to purge which is why she got so thin.
Jaquie's thread is locked so I hope this is okay to post here.
Jan's latest video. She has Jaquie, Judd and Harlow in the opening credits now. This may mean more videos relating to Jaquie from her. Judd brought Harlow out as a service dog. She's now besties with Jaquie's church 'friends'. Hilarious mother's day church song.
