Wuhan Coronavirus: Megathread - Got too big

[Gustav Schuchardt]

How bad will the damage get in NYC? Didn’t take too long for them to top Washington State. Makes me grateful to live in a flyover state.

I bet the people in the flyover villages far from Sodom and Gomorrah felt the same way when they heard the news that the Lord had woken up one day to angry right-wing ecelebs showing him videos of drag queen story hours, bugchasers and rampant butt banditry there and decided that enough was enough and they needed to be cleansed of their impurities regardless of the regrettable 100% human, animal, and microbial fatality rate.

 

[Cure Milquetoast]

Social distancing during coronavirus pandemic? Not in Bay Area parks

Marin County orders all parks closed as crowds flock to the outdoors for exercise and fresh air.

www.sfchronicle.com

[http://archive.li/NVXHJ]

People legitimately don't understand what six feet is. Frankly, I just imagine a dead Scandinavian man right in front of me and use that as a reference.

 

[Archeopthryx]

Now that people are forced to home school I'll be streaming and releasing lessons. First lesson: Epstein didn't kill himself. What does it really mean? A primer for beginner skepticism and post-post-modernism.

 

[Dr. Geronimo]

When do you guys think the lockdowns will slowly be lifted? I think in a week or two but some areas want to see people suffer and they won’t do anything.

I'm still banking on going on a trip in late April. I have a feeling things will steady out by then.

 

[Stoneheart]

Maybe switch from smoking to vaping. The cool kids will probably tease you a bit and you won't be an alpha pack leader but you'll still be able to hang with the pack.

But Vaping makes you gay and i dont want to be gay.

Also that 60%+ ethanol stuff was excellent for starting fires without tinder.

just use cheap rum. also wtf USA? how can they outlaw stuff that works well infavour of stuff that doesnt work.

Isopropyl alcohol will work too.

 

[DNA_JACKED]

But Vaping makes you gay and i dont want to be gay.

Smoking is pretty gay fam. Sticking hot fags in your mouth and sucking on them all day......

 

[EmuWarsVeteran]

PP still trying to hand medals and lying like bitches. They've gone full retard, like Democrat levels of full retard, but so far the only worrying part is what kinda deal Ayuso has done with china, and rumor is it's only a case of giving them a fuckton of money, so maybe, just maybe, we won't end up sold to the chinks by the people claiming their opponents are commies. The pro-chink propaganda is getting out of control in mainstream media though. We'll see what the fuck that turns into.

Other than that morale is generally fairly high besides everything. Checking private chats and general reception it's still high albeit lower than yesterday's. Seems old folks' homes suffering a bit but no more than it was to expect, the public prosecutors claim they'll research the tragedies but we all know it won't go anywhere because the reason this is shit is guvernmental mismanagement. Carmen Calvo falls sick with some kinda respiratory infection, which is important because her test gave negative, so either she's been infected very recently or there's a very good chance congress is now a corona hotspot. Taking into account how imcompetent these fucks have been fingers crossed they all get it.

Overall, wishing we had britbongs or polacs on the government, but still thankful we don't have frenchies or italians.

 

[Rohan Davey]

My friend is from Charlotte. He says so many Yankees are there that it's hard to find native Carolinians.

Charlotte is essentially a giant Bank of America branch that a million people decided to live inside of for some reason.

 

[simulated goat]

I found an interesting study from 1942(!) on the antiviral properties of propylene glycol mist

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135271/
https://web.archive.org/web/20200316080441/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135271/

Maybe switch from smoking to vaping. The cool kids will probably tease you a bit and you won't be an alpha pack leader but you'll still be able to hang with the pack.

 

[Agent Abe Caprine]

Thingy printer is making beautiful brrs.

Leitat presents first medically validated, industrialized 3D printed emergency respiration device*

The alliance (which our Spanish language sister website reported on just a few days ago) between the Consorci de la Zona Franca (CZFB), HP, Leitat (Tecnio) together with CatSalut, through the Consorci Sanitari de Terrassa (CST) and the Hospital Parc Taulí de Sabadell, have developed the first...

www.3dprintingmedia.network

Archive

"China has responded to the crisis with unprecedented openness and bough the world more ..."

https://www.scmp.com/news/china/soc...virus-cases-may-be-silent-carriers-classified

A growing number of studies are now questioning the WHO’s earlier statement that asymptomatic transmission was “extremely rare”. A report by the WHO’s international mission after a trip to China estimated that asymptomatic infections accounted for 1 to 3 per cent of cases, according to a European Union paper.

“The number of novel coronavirus (Covid-19) cases worldwide continues to grow, and the gap between reports from China and statistical estimates of incidence based on cases diagnosed outside China indicates that a substantial number of cases are underdiagnosed,” a group of Japanese experts led by Hiroshi Nishiura, an epidemiologist at Hokkaido University, wrote in a letter to the International Journal of Infectious Diseases in February.

https://news.rthk.hk/rthk/en/component/k2/1516240-20200323.htm

Officials say these tests are not needed as the number of new infections has fallen sharply.

But a Wuhan resident, who gave his surname as Wan, disputed this claim. He said that his 70-year-old mother suffered from pneumonia once again after she was discharged from hospital and is now in isolation at a hotel.

He said no hospitals were prepared to admit her because she wasn't tested positive.

https://archive.fo/hi4PJ - SCMP

https://archive.vn/tx1CY - RTHK

Any Wuflu articles from Hong Kong are in danger of being deleted in the future. Please be prudent about archiving stuff from those.

 

[Pomeranian bitch]

Also, being on the fluid means nothing. Alm that means is that this virus is good at getting everywhere. But to actually damage and infect neurons the virus would have to first get through the mielin spiral, which is fucking excessive, very few things get through that and there is no evidence of the virus doing so.

On mielin spirals: for those that don't know. Neurons are so specialized they don't even maintain themselves, instead their axons are covered by glial cells which take care of them and do all their metabolic and maintenance functions. These cells grow by twisting themselves over and over again around the axon, forming a spiral made of mielin (cellular membranes), a pathogen wishing to damage the neuron has to manage to get through the whole spiral oayer after layer, each of which has defense mechanisms meant to detect and either expell or digest pathogens. I assure you, it's really fucking hard. Saying that a virus causes neurological damage just because it's in the fluid is like saying that someone has managed to escape from SOVIET RUSSIA just because they managed to get out of their bathroom.

I just want to add that infection of such cells by virus is possible and some of them are very ubiquitous

(from Wikipedia)

Neurotropic viruses that cause infection include Japanese Encephalitis, Venezuelan Equine Encephalitis, and California encephalitisviruses; polio, coxsackie, echo, mumps, measles, influenza and rabies, as well as diseases caused by members of the family Herpesviridae such as herpes simplex, varicella-zoster, Epstein–Barr, cytomegalovirus and HHV-6 viruses.

Those causing latent infection include herpes simplex and varicella-zoster viruses. Those causing slow virus infection include measles virus, rubella and JC viruses, and retroviruses such as human T-lymphotropic virus 1 and HIV.

If influenza can cause neurological damage, I don’t think it’s far fetched to assume that nCov could too.

 

[Eryngium]

How bad will the damage get in NYC? Didn’t take too long for them to top Washington State. Makes me grateful to live in a flyover state.

Best damage and rioting prediction tool right here for anyone looking to make some bets.

 

[simulated goat]

Biden just spoke. He looked like hell, was basically whispering in front of a green screen. BRUTAL.

He's dead now as per the celeb thread. His campaign just announced it. Or fake news. Who can tell these days?

Now , just whose hand did he shake and whose hair did he coof on?

 

[Idonttrustlikethat]

What do people think, will Corona overtake swine flu's numbers?

 

[Drain Todger]

Not really. Thing is the reason for the smell obstruction is due to inflamation of surrounding area, not damage to the cells themselves. The flu and colds do this too. The thing is this virus does it more often and more notably.

Also, being on the fluid means nothing. Alm that means is that this virus is good at getting everywhere. But to actually damage and infect neurons the virus would have to first get through the mielin spiral, which is fucking excessive, very few things get through that and there is no evidence of the virus doing so.

On mielin spirals: for those that don't know. Neurons are so specialized they don't even maintain themselves, instead their axons are covered by glial cells which take care of them and do all their metabolic and maintenance functions. These cells grow by twisting themselves over and over again around the axon, forming a spiral made of mielin (cellular membranes), a pathogen wishing to damage the neuron has to manage to get through the whole spiral oayer after layer, each of which has defense mechanisms meant to detect and either expell or digest pathogens. I assure you, it's really fucking hard. Saying that a virus causes neurological damage just because it's in the fluid is like saying that someone has managed to escape from SOVIET RUSSIA just because they managed to get out of their bathroom.

A lot of signs seem to point to exactly that; the neuroinvasive potential of betacoronaviruses. I picked up a few books recently, including Fields Virology 6th Edition, and I’m trying to catch up on some things related to these viruses. Also, some papers I’ve gone over have indicated that in transgenic hACE2 murine models (ordinary mice don’t have human-like ACE2 and the virus can’t enter their cells as efficiently), SARS-CoV (which is 80% genetically-homologous to SARS-CoV-2) was capable of causing severe neurological damage.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2493326/

I’ve highlighted the important parts in gold.

Herein, we use these mice to show that virus enters the brain primarily via the olfactory bulb, and infection results in rapid, transneuronal spread to connected areas of the brain. This extensive neuronal infection is the main cause of death because intracranial inoculation with low doses of virus results in a uniformly lethal disease even though little infection is detected in the lungs. Death of the animal likely results from dysfunction and/or death of infected neurons, especially those located in cardiorespiratory centers in the medulla. Remarkably, the virus induces minimal cellular infiltration in the brain. Our results show that neurons are a highly susceptible target for SARS-CoV and that only the absence of the host cell receptor prevents severe murine brain disease.

While virus replicated to high levels in the lungs of these Tg mice, extensive virus replication was also detected in the brain (32, 49). Virus was not detected to a significant extent in this organ at day 2 p.i., but by day 4, a large fraction of cells, predominantly neurons, expressed viral antigen. We detected regional differences in the extent of infection, with some areas of the brain, such as the cerebellum, remaining uninfected while others, such as the thalamus, cerebrum, and brainstem, were heavily infected (32). These results were not anticipated because hACE2 expression levels in the brain were no more than 0.1 to 1% of those in the lungs. This extensive brain infection was postulated to be a major factor in the aspiration pneumonia that we observed. While virus was detected in the brain in several studies of patients infected during the outbreak of 2002 to 2003 (14, 20, 53), virtually no infected human brains are available for further study, making it difficult to investigate SARS-CoV-induced neurological disease.

Examination of brain sections from mice inoculated with 3.2 or 320 PFU of SARS-CoV revealed that the dorsal vagal complex (nucleus tractus solitarii, area postrema, and dorsal motor nucleus of the vagus), critical for cardiorespiratory function, was infected in all four samples examined (Fig. (Fig.3H).3H). We also examined brains from mice inoculated intracranially (Fig. (Fig.3I)3I) or intranasally (Fig. (Fig.3J)3J) with high doses of virus and observed that the dorsal vagal complex was infected in all instances. Thus, the fulminant disease occurring in SARS-CoV-infected K18-hACE2 mice may result from infection and functional impairment of this critical brain region.

Basically, the cardiorespiratory centers of these mice were so severely affected, they suffered aspiration pneumonia and died. They could not breathe correctly.

There is another study that suggested the neuroinvasive potential of SARS-CoV-2 be more heavily investigated, specifically because of the shared genes between SARS-CoV and SARS-CoV-2 and likely shared pathological traits:

Error - Cookies Turned Off

Following the severe acute respiratory syndrome coronavirus (SARS‐CoV) and Middle East respiratory syndrome coronavirus (MERS‐CoV), another highly patho- genic coronavirus named SARS‐CoV‐2 (previously known as 2019‐nCoV) emerged in December 2019 in Wuhan, China, and rapidly spreads around the world. This virus shares highly homological sequence with SARS‐CoV, and causes acute, highly lethal pneumonia coronavirus disease 2019 (COVID‐19) with clinical symptoms similar to those reported for SARS‐CoV and MERS‐CoV. The most characteristic symptom of patients with COVID‐19 is respiratory distress, and most of the patients admitted to the intensive care could not breathe spontaneously. Additionally, some patients with COVID‐19 also showed neurologic signs, such as headache, nausea, and vomiting. Increasing evidence shows that coronaviruses are not always confined to the re- spiratory tract and that they may also invade the central nervous system inducing neurological diseases. The infection of SARS‐CoV has been reported in the brains from both patients and experimental animals, where the brainstem was heavily infected. Furthermore, some coronaviruses have been demonstrated able to spread via a synapse‐connected route to the medullary cardiorespiratory center from the mechan- oreceptors and chemoreceptors in the lung and lower respiratory airways. Considering the high similarity between SARS‐CoV and SARS‐CoV2, it remains to make clear whether the potential invasion of SARS‐CoV2 is partially responsible for the acute respiratory failure of patients with COVID‐19. Awareness of this may have a guiding significance for the prevention and treatment of the SARS‐CoV‐2‐induced respiratory failure.

The phrase “able to spread via a synapse-connected route to the medullary cardiorespiratory center from the mechanoreceptors and chemoreceptors in the lung and lower respiratory airways,” pretty much unambiguously means that the virus is able to climb directly from the lungs and into the cardiorespiratory center of the brain stem, like the proverbial spider going up the water spout. It may also be capable of causing cerebrovascular disease and crossing the blood-brain barrier, or even passing through the olfactory bulb and through the cribriform plate into the brain.

COVID-19 is very likely to be a brain-eater, just like the fictional MEV-1 from Contagion.

A brain-eating airborne disease.

I don’t know how to make this any clearer. I keep seeing people denying it over and over because they just don’t want it to be true. Believe me, I don’t, either. I’m in Seattle, for fuck’s sake.

 

[EmuWarsVeteran]

A lot of signs seem to point to exactly that; the neuroinvasive potential of betacoronaviruses. I picked up a few books recently, including Fields Virology 6th Edition, and I’m trying to catch up on some things related to these viruses. Also, some papers I’ve gone over have indicated that in transgenic hACE2 murine models (ordinary mice don’t have human-like ACE2 and the virus can’t enter their cells as efficiently), SARS-CoV (which is 80% genetically-homologous to SARS-CoV-2) was capable of causing severe neurological damage.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2493326/

I’ve highlighted the important parts in gold.







Basically, the cardiorespiratory centers of these mice were so severely affected, they suffered aspiration pneumonia and died. They could not breathe correctly.

There is another study that suggested the neuroinvasive potential of SARS-CoV-2 be more heavily investigated, specifically because of the shared genes between SARS-CoV and SARS-CoV-2 and likely shared pathological traits:

Error - Cookies Turned Off

The phrase “able to spread via a synapse-connected route to the medullary cardiorespiratory center from the mechanoreceptors and chemoreceptors in the lung and lower respiratory airways,” pretty much unambiguously means that the virus is able to climb directly from the lungs and into the cardiorespiratory center of the brain stem, like the proverbial spider going up the water spout. It may also be capable of causing cerebrovascular disease and crossing the blood-brain barrier, or even passing through the olfactory bulb and through the cribriform plate into the brain.

COVID-19 is very likely to be a brain-eater, just like the fictional MEV-1 from Contagion.

A brain-eating airborne disease.

I don’t know how to make this any clearer. I keep seeing people denying it over and over because they just don’t want it to be true. Believe me, I don’t, either. I’m in Seattle, for fuck’s sake.

All I can tell you is I've seen 2 outbreaks, live with someone that tested positive, and while I haven't been tested have many symptoms, and that sounds like nothing I've seen and also nothing I've heard from the medical profesionals dealing with this virus here in spain. I'm not gonna say it won't happen in an EXTREME MINORITY of cases, but it sure as shit ain't even close to common, not in spain anyway, and knowing our luck I doubt we've gotten a mild strand compared with the rest.

 

[DubbleBubble]

How bad will the damage get in NYC? Didn’t take too long for them to top Washington State. Makes me grateful to live in a flyover state.

It would all be over so much faster if people would stay the fuck home. It's like the average american is just one missed football game and college party away from civil war 2.0 but even Italians are starting to get the message as the numbers in the rest of the world are beginning to hit a curve, while the US skyrockets, and that's with the heavy under reporting going on.

Like, before all this i planned a nice trip back to the states to see family, now since they're all unhealthy fat/old fucks I hope there's some family left after this.

 

[simulated goat]

But Vaping makes you gay and i dont want to be gay.


just use cheap rum. also wtf USA? how can they outlaw stuff that works well infavour of stuff that doesnt work.

Isopropyl alcohol will work too.

Cheap rum costs me almost twenty bucks after taxes. Fuck if I'm gonna smear drinkable alcohol all over surfaces. It should kill germs inside as well as out. Priorities.!

 

[Marchesa of the Vast]

while the US skyrockets

The skyrocket is because the big backlog of tests are being pushed out very quickly now. Give it a few days to a week for that to normalize. You can't tell much from the curve right now.

 

[NevskyProspekt]

US cities are weird in that they are mostly their metroplex. For example, you can't look at Dallas and say that's the population in that city when it's more accurate to list the DFW that's ~6.3 million.

This is entirely correct. DFW actually surpasses Houston as the largest urbanized area in Texas. It basically functions as one immense megacity spread out over 2,500+ square miles, with tacky McMansions, strip malls, surface parking lots and pointlessly wide and complex mega-highways spreading out as far as the eye can see. The sprawl is pretty awful - it takes at least 45 minutes to get anywhere. Californians flooding in certainly didn't help.