But where France-Soir puts particular emphasis on is the dosage of hydroxychloroquine: 2400 mg in the first 24 hours.
The authors compare the dosage to what is recommended in the United Kingdom and in France, respectively by National Institute for Health and Care Excellence (NICE) and Agence Nationale de Sécurité du Médicament et des Produits de Santé (ANSM).
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In the UK, the recommended maximum daily dosage is about 500 mg; while in France, 6.5 mg per kg per day (example: 490 mg for an 75 kg person) is considered safe for people who are not overweight.
In France, 25 mg per day (i.e. 1875 mg per day for a 75 kg person) is considered unsafe.
The French guidelines indicate as possible effects of such dosage: headache, visual disturbance, cardiovascular collapse, hypokalaemia, rhythm disturbance, conduction disturbance and convulsions, rapidly followed by sudden respiratory and cardiac arrest.
The French guidelines mention that such effects can happen very quickly after ingesting a massive dose, and that emergency treatment must take place very rapidly: gastric lavage, activated charcoal or even symptomatic resuscitation.
http://agence-prd.ansm.sante.fr/php/ecodex/rcp/R0271872.htm
It must be stressed that, with such high dosage, it’s very likely that patients knew right away if they were getting the excessive dose of hydroxychloroquine or the placebo – which made instantly the very concept of the randomized controlled trial pretty useless.
Oxford Academics Confusing Hydroxychloroquine with Hydroxyquinolines?
The France Soir newspaper interviewed one of the principal researchers of the Oxford RECOVERY trials, Professor Martin Landray, MB ChB, PhD, FRCP, FHEA, FASN, FBPhS, FESC, Professor of Medicine and Epidemiology, member of the prestigious Nuffield College in Oxford.
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France-Soir asked:
“How did you decide on the dosage of hydroxychloroquine?”
The answer by Professor Martin Landray, is:
“The doses were chosen on the basis of pharmacokinetic modelling and these are in line with the sort of doses that you used for other diseases such as amoebic dysentery.”
And the follow-up question by France-Soir may be even more devastating:
“Are there any maximum dosage for HCQ in the UK?”
“I would have to check but it is much larger than the 2400mg, something like six or 10 times that.”
“ … the HCQ dosage used are not dissimilar to that used, as I said, in for example amoebic dysentery.”
The French newspaper interviewed Doctor Christian Perronne, a Professor of Infectious and Tropical Diseases at the Faculty of Medicine Paris-Ile de France-Ouest, who told them:
“It is indeed the first time that I learn that we use hydroxychloroquine in amoebic dysentery, in addition to the dose being super-toxic for humans.”
“The classic treatment for colonic amoebiasis is based on a combination of hydroxyquinolines, tiliquinol and tilbroquinol, whose trade name is Intetrix.”
“I think they confused hydroxychloroquine with hydroxyquinolines.”
“If my assumption is correct, it is incompetence. Most serious is the use of a huge, potentially fatal, dose,” added Professor Perronne.