Seems like they might be trying to angle it toward George Floyd being diagnosed postmortem which is possible, but given his lifestyle I wouldn't be terribly surprised if he had diagnoses like a shopping list and many of his ailments had probably been comorbid for a long time prior to his death. He was 46 so he wasn't quite at the age where the wheels start to fall off completely, but if you've lived a hard life [drinking, drugs, wild shit] it isn't rare for that shit to begin to catch up with you in your forties.
I think he just happened to OD at that moment, or the stress of the situation pushed him over the edge. As another person here mentioned, the fentanyl hadn't run through his system completely as no metabolites of it were found in the urine. Meaning he'd likely taken that heroic dose of fent just prior to his death. If you combine stress, heart disease, sickle cell trait, a heroic speedball of fentanyl and methamphetamine, he had COVID and was probably a regular smoker of cigarettes and marijuana, it's a wonder he didn't drop dead prior to encountering police. If the police hadn't been called he likely would've been found slumped over the wheel of his car or dead wherever he was heading that day. He might've also wrecked his car due to driving intoxicated. There's a whole host of other things that could've contributed or could've happened if that situation didn't play out. I'd be interested to know if Floyd ever communicated any suicidal thought or intent. I guess it's also possible that he didn't take the fentanyl on purpose. A lot of the 'prescription' pills on the street, supposedly Vicodin or Oxycodone, are presses made out of fentanyl now since the FDA/DEA clamped down on over-prescription of the real thing. I've even heard of Xanax/Klonopin being pressed with fent. Street coke or heroin can be fent too or mixed with fent.
Either way, the guy would've been dead plus or minus twelve hours whether he encountered the police or not, that's what I think.