wtf he still comes at her after being shot several times. I get why some cops still hold onto revolvers now.
10 shots, 7 misses, 3 hits, approximately. The first shot, she flinched and fired while aiming high and left. The subsequent shots, panic sets in, she keeps flinching and doesn't know where to hold. The suspect is blading his torso and is difficult to hit. She keeps shooting high and to the left. As the suspect's hand grabs her gun, she finally scores one hit, probably to the lower abdomen judging by how he hunches, and then, she finds that her weapon has not cycled because she fired it while the slide was immobilized by the suspect's hand. Fortunately for this officer, the suspect did not maintain a firm grip on the weapon and attack with his other hand. Once she regained retention of the weapon, she stepped back, cleared the malfunction... and then missed three more times before finally putting two kill shots into him.
A revolver won't fix this. In fact, it will make it worse because of the anticipation of the recoil producing flinch. There is one device I can think of on the market that can fix this. It’s called the MantisX. It's a little light rail attachment for a pistol that uses an accelerometer to tell you exactly what you're doing wrong.
only on the principle of throwing so much shit at the wall that some of it inevitably smeared in place.
Someone else I know IRL just died of COVID-19. He had pneumonia and kidney failure.
COVID-19 patients present to the ER with fever, dry cough, and shortness of breath. Body aches are common. When the ER docs put a pulse oximeter on these patients, they can see that they're deoxygenating. Their O2 saturation is dropping rapidly. Someone with normal respiration and pulse has an O2 sat of greater than 95%. These patients are below 90% and dropping rapidly. Some of them are below 70% and turning blue in the face. When they go to perform lab work and tests on these patients, this is what they generally find:
- Hypokalemia (low blood potassium)
- Abnormal AST/ALT levels (liver enzymes are messed up)
- High ferritin (there are lots of iron storage proteins floating freely in the blood)
- High troponin (usually, this is indicative of heart damage)
- High C-reactive protein (lots of inflammation)
- High D-dimer (lots of breakdown products indicative of blood clots)
- Lymphopenia (low lymphocytes)
- Thrombocytopenia (low platelets)
- Albuminuria (albumin in urine)
- Hematuria (blood in urine)
SARS-CoV-2 does the following things to the human body:
- It down-regulates ACE2, leading to an excess of Angiotensin II and a cascade of AT1R-promoted inflammation, oxidative stress, fibrosis, and coagulopathy.
- It may attack cells through the CD147 receptor as well.
- It promotes excess aldosterone secretion, leading to hypokalemia.
- It decimates T lymphocytes in the body, leading to lymphopenia.
- It reduces interferon and blunts the innate immune response.
- It promotes endothelial dysfunction and reduces nitric oxide bioavailability by interfering with its synthesis.
- It causes abnormalities in iron metabolism.
- It interferes with lipid metabolism and the urea cycle.
- It can promote cell-to-cell fusion and the formation of giant, multinucleated cells.
- It promotes cytokine storms with a very severe inflammatory profile dominated by up-regulation of IL-6, IL-10, and TNF-α, among other things.
And, from those basic mechanisms, this is how COVID-19 actually manifests (some of these complications are much rarer than others):
- Endotheliitis
- Viremia
- Sepsis
- Encephalitis
- Meningitis
- Guillain-Barre
- Rash
- Conjunctivitis
- Coagulopathy
- Hypoxemia
- Seizure
- Stroke
- Delirium
- Cardiomyopathy
- Heart attack
- Pulmonary embolism
- Pulmonary edema
- Pulmonary fibrosis
- Hemoptysis
- Bilateral pneumonia
- Myositis and Rhabdomyolitis
- Mild hepatitis
- Acute kidney injury
- Viral colitis
- Orchitis
- Kawasaki disease (in children)
This isn't just "throwing shit at the wall". That isn't even a comprehensive list of what it can do. Because of the ubiquity of its entry receptors, SARS-CoV-2 attacks a wide variety of human cell lines and it does so voraciously. It can actually do all of those things, or a combination of any of them. In fact, COVID-19 is so variable in its effects, people sometimes present to the ER with gastrointestinal or neurological symptoms without any respiratory signs whatsoever, and then
later develop pneumonia. There is a possibility that SARS-CoV-2 may even attack bone marrow and the immature blood cells within.
SARS-CoV-2 colonizes the body through a number of routes. It can land on the olfactory nerve and enter the brain directly from there. It can land in the eyes and cause conjunctivitis. It can be breathed in and colonize the respiratory tract. It can even colonize the GI tract before anything else.
COVID-19, as a disease process, proceeds approximately like this in severe and critical cases:
- SARS-CoV-2 enters the body through any of a number of routes.
- The virus gets into the lining of blood vessels and causes endotheliitis and viremia, infecting the endothelium and circulating in the bloodstream.
- The virus suppresses the innate immune response by reducing T cell populations and inhibiting interferon, allowing it to replicate with impunity.
- In the process of down-regulating ACE2 and increasing Ang II, the virus promotes tons of inflammation, oxidative stress, fibrosis, and coagulopathy.
- Nitric oxide, which ordinarily has a lifespan of a few seconds in the body, is reduced in a number of ways, such as by production of peroxynitrite due to the superoxide release promoted by Ang II, and also by SARS-CoV-2's interference with carbamoyl phosphate.
- The body's iron metabolism goes crazy from the lack of nitric oxide signaling and from the inflammation. Free iron is released, causing even more cytotoxicity and sequestering even more nitric oxide.
- Endothelial permeability increases due to the eNOS dysfunction and all the ICAM-1 and VCAM-1 floating around.
- Capillaries start leaking into the alveoli, precipitating pulmonary edema and pneumonitis.
- The endothelium flips the fuck out and thinks that it's damaged. Micro-clotting starts occurring everywhere to try and "repair" the damage. Antiphospholipid antibodies are often present in the blood. The endothelium releases von Willebrand factor to try and patch what it perceives as a bunch of holes everywhere. Platelets are urged by the body to form clots.
- The micro-clotting triggers pulmonary shunt in the lungs and the patient starts deoxygenating.
- Hypoxic damage to various vital organs starts to occur, leading to multiple organ failure.
- In the case of a hypoxic brain, seizure, collapse, abnormal posturing, and the fencing response may occur, just like a drowning victim, but this only happens to about 1 in 200 confirmed, symptomatic cases.
- Viremia passes the virus into these organs and promotes inflammation in each of them. It is sometimes difficult to tell apart hypoxic damage and direct inflammation caused by the virus.
- There is inflammation everywhere and the lungs are starting to scar over.
- Sepsis and kidney failure starts to set in.
- Blood clots promoted by the virus can have lethal consequences, like stroke, heart attack, or pulmonary embolism.
- When death occurs, it is usually because a great big clot went where it wasn't supposed to, or because disseminated intravascular coagulation occurred. In extreme cases, severe hypoxemia or multiple organ failure can lead to death as well.
The typical course of the virus is about a week of flu-like symptoms followed by a latent phase of a day or two which then leads to the crazy cytokine storm death spiral described above, which usually lasts about 4 days to a week before the patient recovers or expires. The time from infection to death/recovery can be from 11 days all the way out to a month or two. Some people have been symptomatic for longer than three months. When they recover, many people have lingering lung and brain damage and chronic fatigue, just like SARS.
COVID-19 is not a "lung disease". It is a blood and vascular disease first and a lung disease second. It causes inflammation and clotting. The way it's treated is by giving patients supplemental oxygen or mechanical ventilation and then putting them on blood thinners, trying carefully to balance anticoagulation against hemorrhaging, while also trying to suppress the inflammation and opportunistic bacterial infections with antivirals, steroids, and antibiotics.
Everything I dredged up about the virus came from
peer-reviewed articles in reputable medical journals.
COVID-19 and Coagulopathy
www.hematology.org
COVID-19 is being implicated in damage to several organ systems.
www.mdlinx.com
This is the lung out of a critically-ill COVID-19 patient who needed a lung transplant:
A young woman whose lungs could not recover from the coronavirus infection is doing well after a double lung transplant.
www.sciencenews.org
This lump of hemorrhaging scar tissue came from the chest of a 20 year old Hispanic female. The tissue is basically unrecognizable as a human lung. It looks like jerky.
People have a choice. They can wear a mask and look like a cuck, or they can have meatloaf lung. Vanity or health. 80 cent mask, or huge medical bills. Pick one.
@eternal dog mongler could probably vouch for the scientific accuracy of most of this.
.) draw, paint, carve, print lino, sew, paint 40k figures, learn a language, read that ridiculously thick book on something obscure you've never had time to start. Restore something old. Anything - what doesn’t matter, as long as it’s absorbing and you enjoy it.