Brad Gray
kiwifarms.net
- Joined
- Jul 9, 2020
dr wikipedia is on the case. thanks for shedding light on the opioid crisis.Didn't see this before - sorry.
But yes. All drugs basically show some degree of activity however small at every receptor type. At extremely high tolerances that few ever arrive at, literally everything except extremely high-affinity drugs (methadone or fentanyl) start having unpleasant side effects mediated by their nonspecific effects. Incidentally I find it fascinating that no fortune has yet been made making use of the forty year old literature setting out how to prevent or reverse opioid tolerance by coadministration of morphine with nanograms (i.e. too small to notice, but enough to prevent receptor downregulation) of naltrexone.
I knew someone who had a pretty manageable recreational habit with street drugs at the time MS Contin 100 mg and OxyContin 80mg cost about the same and we're basically considered equivalent by street users. Except this person swallowed his pills and was put in quite the predicament when he could only get the morphine one day: at only 15 percent oral bioavailability, it's only logical to switch to mainlining, and that was that.