I'd really like to hear Kevin try to explain the pharmacology of why the route of administration would matter. He does like to fancy himself a twitter biology/science expert, because troon. I don't know much about progesterone, but the only reason I can think of to administer anything rectally is to bypass the first pass metabolism of your liver breaking shit down before it gets to your bloodstream. It's why some addicts shoot shit up their asses if they don't want to use a needle. I can't imagine it would make any fucking difference of how a hormone affects your body, but it would be funny to see what kind of retarded nonsense Kevin would make up to try and convince people of this shit.