Well, take the radio skits for example. We begin with GTA2 which pokes fun at rampant consumerism and pharma lobby. (
Oh, it seems so easy in the movies, but keeping it up can be a real problem!)
3 is more political, with hints of jobs going overseas
(...our new satellite in China is something all Americans can be proud of.) Later titles continued this trend with talk shows and ad breaks.
There is a sense that the US will sink beneath the waves before it ever accepts that greed is not good: the Bush analog Alex Shrub doesn't want any more sixties counterculture springing up, to the point where he equates vegetarianism with being pro-soviet; the sports show lists off college ball, football and killing communists as America's pastimes; one guy in IV was talking about health care, saying things like, "If your hip hurts, you should just kill yourself. If you fall down and break your hip, it's all over. Don't make
me pay for it", etc. Ammu-Nation is a nothing but extended gag about gun culture. The religious right doesn't get much airplay, likely in part due to Pastor Richards being cut, though LCS has a nice line from "Nurse Bob" about sex being an unnatural act.
4 is supposed to be the dark, serious one, and yet the radio and NPC dialog is really puerile. They hired SNL cast members and writers to do the radio bits and they imported their NYC comedy style, which was a huge mistake.
Lazlow and Maurice used to play straight men. This time there is no straight man, and it is part of the reason why the satire feels flat. Lazlow is an annoying perverted douche. He is so over-the-top with his self-loving personality that he shoves a hot dog vendor's face into boiling water. Then came the recent DLC where he is even cringier than ever. There's a lot about modern politics they could satirize, or
try to, but no, let's hear more offensive jokes about Lazlow's coke habit and sexual deviancy, please. It feels like people are holding onto what they liked about him in 3. The talk show hosts shout the same three things over and over and it gets repetitive quickly.