Benjamin Ryan @benryanwriter posted on Saturday, 9 March 2024 at 02:45:12 UTC
A person asked me why it should be considered exceptional or problematic that the research about pediatric gender-transition treatment is no better than low quality when so many other common treatments get by with only low quality evidence quality backing them. I responded:
Benjamin Ryan @benryanwriter posted on Saturday, 9 March 2024 at 02:43:02 UTC
I asked the @segm_ebm conference panelists this question in October and they become so animated they practically burst out of their seats. They said that the risks and downsides of pediatric pubertal suppression and cross sex hormones are so high, namely the prevention of…
Erin Reed @ErinInTheMorn posted on Saturday, 9 March 2024 at 03:34:03 UTC
You're only balancing one side of the risk equation. Not doing anything is not a neutral action. The other side of that equation is developing severe anxiety disorder, major depression, suicidality, and trauma.
As someone who suffered from that, I wouldn't wish it on an enemy.
Benjamin Ryan @benryanwriter posted on Saturday, 9 March 2024 at 03:38:39 UTC
Five systematic literature reviews have asked: "What are the benefits of treating pediatric gender dysphoria with puberty blockers and cross-sex hormones?"
They have found the evidence inconclusive.
Your claims are thus not supported by evidence.
Benjamin Ryan @benryanwriter posted on Wednesday, 6 March 2024 at 18:35:13 UTC
Below are the five systematic literature reviews of pediatric gender-transition treatment that between them have all found that the related evidence is of no greater than low quality. The results are inconclusive.
Consequently, an increasing number of European nations have been…
Erin Reed @ErinInTheMorn posted on Saturday, 9 March 2024 at 03:39:33 UTC
You're just repeating GRADE analyses again, so we're going to talk each other in circles. Still, for others:
The Myth Of "Low Quality Evidence" Around Transgender Care
Benjamin Ryan @benryanwriter posted on Saturday, 9 March 2024 at 03:43:59 UTC
The conclusion of the most recent systematic review: "Current evidence does not clearly suggest that [gender dysphoria] symptoms and mental health significantly improve when [puberty blockers and cross-sex hormones] are given to minors with GD."
Benjamin Ryan @benryanwriter posted on Tuesday, 27 February 2024 at 14:11:34 UTC
A new systematic literature review, by Germans, of puberty blockers (PB) and cross-sex hormones (CSH) to treat gender dysphoria (GD) in kids concludes: "Current evidence does not clearly suggest that GD symptoms and mental health significantly improve when PB or CSH are given to…
Erin Reed @ErinInTheMorn posted on Saturday, 9 March 2024 at 03:50:22 UTC
They literally come to that conclusion through GRADE analysis.
Also, not long after their cutoff, we got a new Puberty Blocker study.
Doesn't matter though, it's not an RCT, which you'll never get ethically or practically.
Erin Reed @ErinInTheMorn posted on Saturday, 16 December 2023 at 21:55:40 UTC
Incredible new transgender study was just published in the prestigious Journal of Adolescent Health.
The study finds that puberty blockers significantly reduce anxiety, depression, and suicidal thoughts compared to those who did not receive blockers.
They are lifesaving.
Benjamin Ryan @benryanwriter posted on Saturday, 9 March 2024 at 03:52:24 UTC
Yes, and although you dismiss GRADE out of hand, scientists take it seriously, which is why the conclusions of the systematic reviews are valid.
Erin Reed @ErinInTheMorn posted on Saturday, 9 March 2024 at 03:54:54 UTC
Like I said, we'll talk each other in circles.
There's a reason the worlds biggest psychological organization, the most influential medical organizations, all reject your logic.
The Myth Of "Low Quality Evidence" Around Transgender Care