I think that asides from the fact that his mother will be dead in a few years maximum, Chris's financial issues are putting a massive strain on him.
His and Barb's debts has gotten so high while their expenditure on necessities has stayed the same, and they can't seem to stay out of trouble when it comes to fines and legal cases with credit card companies on top of that. All of that combined now means that every single month without fail, Chris reaches a point where he needs, or is told by Barb that he needs, large amounts of donations from the internet to get by. As well, every single month he's finding it harder to receive donations.
That sort of financial uncertainty, month in month out would put a massive strain on anyone. No matter what anyone says, this year has been the year where Chris's finances have slowly got worse and worse, as his responsibility to keep the Chandlers afloat has got higher and higher. Chris wasn't built to cope with adult stresses like that, so instead he's thrown himself into offering his long winded opinions on inane clickbait, watching children's cartoons and seriously stepping up his quest to have a vagina, something which we all know has put himself in serious physical danger.
It's clear that Chris is drowning in his struggles to live an adult life and unless by some miracle his life improves massively, things are only going to get worse and worse for him from here on out.