I find the progression of faces through the series to be kind of interesting.
Mass Effect had similar doughball faces as Andromeda, but that was a limitation of the technology. The difference though was that the jaw and cheekbones weren't hideously overblown and so it was still immediately identifiable as a face.
Mass Effect 2 did a bit better along every line for faces but they sometimes seemed a little off. Not awful enough to draw the eye, but there nonetheless. They did get facial animations to a nice high point though, and that helped alleviate the underlying facial weirdness.
Mass Effect 3 hit a high point since faces looked like faces with no doughball look and the jaws and cheeks bones were appropriately sized for the build of a special forces operative. Eyes were still a bit funny, but they didn't go weird in the way the first game did. Default Shepherd for both sexes was good looking and didn't have any problems with believability or humanity.
Now we hit Andromeda where we have exploded jaws and cheeks that causes enough problems with our natural pattern recognition to throw up mental red flags. Andromeda doesn't have faces that classically resemble humans. They're overblown and out of proportion so our brains see them as weird and not right.
Bioware can patch all they like, but the only fix is going to be rebuilding facial meshes and skeletons and reworking textures and the creation sliders.