Taking the question literally (ie. 5% autismo mode)- Whichever genre that has minimal-to-absent non-verbal communication (which is many), does not involve social interaction (rules out any multiplayer), is exceptionally repetitive, has minimal variation in environment or gameplay, and seldom includes human voice.
Owing to those limitations, I'd argue that the greatest number of titles that near-fully (or fully) match that criteria are Retro games (OG, not neo-Retro). The best example that comes to my mind is Tetris.
In a more modern setting, I'd also argue that the 'speedrun' meta-genre counts for 2D platformers, alongside exceptionally repetitive titles, such as that silly Flappy Bird game from the early 10's.