Guys, I think we're witnessing the birth of a nihilist here.
OP, you seem to be a tad obsessed with the notion of relationships being meaningless because everyone and everything inevitably dies or is destroyed. If that were the case, why even post here? Even assuming we want to be your friends and help you (which from your posts in this thread alone, we don't), we are all gonna die anyway.
Everything dies and stays dead, but there aren't any rules that say things that die actually stay dead forever and everywhere; in fact, the opposite is true. For example, you could clone Sheldon (start taking and freezing healthy tissue samples now before he's dead), travel back in time and steal a baby Sheldon from yourself (uh oh, paradox), steal another Sheldon from another universe, or perfectly emulate a healthy Sheldon via a powerful computer.
In addition, if it's cancer, some forms of cancer are immortal, meaning they can reproduce forever and never die, whereas all healthy cells are destined to die. Sheldon might die, but if you want you could always preserve his live tumor culture till then end of time by feeding it daily and watching it grow as a living memorial to him. It would be just like having a Chia Pet, except it won't ever die, so you don't have to worry about loss like the pansy you are.