Not too familiar with the lore since I'm not a big fan of the franchise, but I noticed some interesting symbolism while playing 8.
All 4 royal bloodlines are obviously based on European ethnicities:
Dimitrescu is Hungarian/Romanian and loosely based on Elizabeth Bathory, Dracula, and the blood rituals the Hungarian/Romanian elites were rumored to do (Order of the Dragon). The crest is a rose cross, which could be a nod to the Rosicrucians.
Beneviento is Italian, possibly a nod to the infamous Black Nobility. Pinocchio was created by an Italian.
Moreau is French, and the fish symbolism is possibly a nod to the Merovingian/Jesus/Magdalene grail bloodline from France. Mary Magdalene is associated with mermaids. The original templars (Umbrella?) were mostly from a French (possibly franco jewish) bloodline.
Heisenberg is German/Jewish. Obviously Germans are known for their engineering, and of course he's naturally the one to rebel against the dark mother. His crest is a Saxon Steed, a popular German crest symbol.
Mother Miranda = Dark Mother Cybele, or better yet, the Black Madonna. Makes sense she's the foundation to the creation of Umbrella, who are obviously loosely based on the Templars and their offshoots. Eva = Latin for Eve, the symbolism is obvious.
Ethan serves as a Jesus/Attis figure who sacrificed himself for his daughter, serving as an excuse to pump out more of these titles with a new archetypical girl boss protagainst. The whole trope of the masucline dad sacrificing themselves for the feminine daughter seems to be all over media these days, yet barely for the son. What are they implying? What say you?