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Conclusions: Our data reveal a sex-atypical INAH3 volume and neuron number in transsexual male-to-female people to be in the female range, while the values of a female-to-male subject were in the male range. Differences in adult testosterone levels can only partly explain the observed differences in the INAH3 subdivision of transsexual people while estrogen levels do not seem to have an influence. In male-to-female subjects the number of neurons in the INAH3 does not seem to be related to sexual orientation, nor to the onset time of transsexuality, but rather to atypical early female-biased gender. The differences observed between the INAH3 structure, its innervation in relation to sexual orientation and gender identity and its putative connection to the BSTc suggest that these two nuclei, together with the SDN-POA (= intermediate nucleus, = INAH1 and 2) and the SCN (Swaab
et al., 1985) are part of a complex network involved in various aspects of sexual behaviour. For the INAH4 subdivision of the uncinate nucleus, the only difference found among the groups was in relation to its shape, which was similar in all genetically male groups studied.
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I got all of these studies from
this study which said this:
“Accordingly, various studies report closer resemblance between transgender people and control subjects with the same gender identity than to those sharing their biological sex. This includes local differences in the number of neurons and volume of subcortical nuclei (
Zhou et al. 1995;
Garcia-Falgueras and Swaab 200). functional alterations of regional cerebral blood blow (
Nawata et al. 2010) and neuronal activation (
Schoning et al. 2010) as well as structural differences of gray (
Simon et al. 2013) and white matter microstructure (
Rametti, Carrillo, Gomez-Gil, Junque, Segovia et al. 2011;
Rametti, Carrillo, Gomez-Gil, Junque, Zubiarre-Elorza et al. 2011). Although transsexual people exhibit similar hormonal levels in adulthood as control subjects of the same biological sex, these studies indicate a transition of specific characteristics of their brains to the actual gender identity (i.e., feminization or masculinization).”