The game tries to state that the latex monsters are technically on humanity's side and are just trying to help, but looking past the surface confirms that both types of monsters are actively hostile. The black latex monsters are admittedly a little less monstrous: some lore indicates that the hostility is more from having a literally alien mindset, with their progenitor - the Wendigo - being a supernatural cosmic horror that views individuality as a plague and is implied to be in a constant state of panic from being around humanity. In fact, most of the black transformations indicate that Colin's mostly kept his sanity despite being brought into a hive mind, though that's admittedly debatable.
The white latex monsters have zero excuse, however. It's shown that they're all sex-obsessed sadists, with the lizard transformations outright stating that Colin is getting anally raped, and every other transformation being fetishistic in some way; what's worse, is that Colin is indicated to be conscious in most of these, being physically unable to prevent his body from being used as a fetish object. The biggest condemnation comes from "Tail", the "sergal" that's revealed to be the latex monster that caused the end of the world; during the day of the riots, it broke out of its containment and actively slaughtered everyone in its path, before spreading both the plague and the latex monsters worldwide. Not helping the story's case is that you're forced to play as Tail during a flashback sequence; and yes, the game tries to portray it as a mindless monster that's only acting on instinct, even when it's shown to be deliberately hunting people down and setting traps.
Also, here's a fun fact: if I read correctly, Tail is actually the author's fursona. Playing as the author avatar as he gleefully slaughters humanity, while the game tries to portray it as excusable, without an ounce of self-awareness... you can't make this shit up, folks.
Yet another issue is Dr. K., as the game falls into the common trap of telling, not showing. Again, we're supposed to view him as the last line of humanity's defense against oblivion, but... well, he refuses to explain anything until he's backed in a corner, repeatedly tries to murder/lobotomize Colin with a rather gleeful smile on his face, and every little lore detail fits a bit too well with his viewpoints, which tend to be rather misanthropic at best. Hell, game accidently implies that he's an unreliable narrator; it gets explicitly stated that none of the scientists had ever been able to find a way to keep their sanity with the white latex, and yet K. somehow did? Reminds me of that EXTREME MEATPUNKS FOREVER game with that accidental self-own...
The endings further the sense of bleakness; every single one has Colin dying in some way. Either he dies from the plague that oh-so-conveniently activates and kills him shortly after getting out of the lab - which further goes on to kill the rest of humanity, somehow - or he stays trapped in the lab, either dying or getting turned into a lobotomized animal. Even the "best" ending suggests that Colin ends up getting his personality rewritten in some way, while the supposedly innocent Puro is heavily implied to have killed someone to use their body as a host.
All that, and the furfag fandom tries to praise and defend it. Worse, they try to use the game to groom minors, while repeatedly insisting that the game "isn't as bad" as the "haters who don't know anything because they don't understand it".
It's all just... absurd.