Qubes OS isn't really a Linux distro but is an interesting OS that I've been meaning to play with and learn about. It seems perfect for use on my laptop whenever I'm moving around and on untrusted wifi networks or in a place where I may have a USB being whored around.
General & Security What is Qubes OS? Qubes OS is a security-oriented operating system (OS). The OS is the software that runs all the other programs on a computer. Some examples of popular OSes are Windows, macOS, Android, and iOS. Qubes is free and open-source software (FOSS). This ...
www.qubes-os.org
Qubes is a security-oriented, free and open-source operating system for personal computers that allows you to securely compartmentalize your digital life.
www.qubes-os.org
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As I understand it, you basically compartmentalize
everything in such a way that it is exceedingly difficult for anything nasty to access data it shouldn't and this is done by spinning up many virtual machines to break everything up depending on the service/application.
It's not a multi-user system which probably isn't a problem for most personal devices, but is something to consider.