Sorta related, but when I was an acne-ridden teen I worked in a supermarket doing grunt work. One of my coworkers was a 50-something fat guy who looked like a Hells Angel, and had a temper to match. He was called Dave. I referred to him as Dynamite Dave. Anyway, DD found out he had diabetes, and was told my doctors he'd eventually lose his sight. He knew an older man who had the same thing, and he eventually took his life.
I left that place after like a year. Found myself shopping there years later, and ran into a girl I used to work with. She mentioned that Dave eventually left work due to blindness, and killed himself.
For me, losing my eyes would be a death sentence. I'd probably say the same for my legs/arms too. Anything that would impede my ability to enjoy fitness, more digitally-demanding hobbies, etc. I think it goes without saying that if I had a horrendous facial disfigurement, I'd off myself too.