1. The world outside your head is real.
2. Emotions Are Feelings, feelings are reactions to external stimuli. Just like hot, cold, pleasure and pain.
3. Your nervous system does more work than your actual brain does.
4. Your brain is merely a transceiver between your soul and physical body.
Therefore it stands to reason that if you engulfed in the depression meme, either your life sucks, you are being assailed by demons or you're a pussy.
You may proceed as you see fit.