Your favorite nootropic? - What chems you shooting into your brain this week! ( no source talk )

[KillaSmoke]

Cardarine is great for endurance, but given the potential concerns around cancer risk, there are much better places to start. If you had an event, or maybe wanted to really boost endurance for a month or two, I don't think that cardarine is so dangerous that its not viable in that context, but I'd advise against running it long term.

If you specifically wanted an endurance drug that's falsely marketed as a SARM, despite having zero interaction with the androgen receptor, then SR9009 isn't bad. Its a rev-erb agonist, and modifies the expression of genes involved in circadian rythym. Basically, it does the opposite of melatonin, and tells your body that its morning time. There's a good amount of super promising rodent research, where it seems to improve almost every aspect of health. Improved lipids, insulin resistance, improved recovery from cardiac surgery, anxiety reduction on with benzodiapenes (minus intoxication and addiction risk), stops the progression of certain breast cancers, improved body composition without any diet/lifestyle modifications, etc, etc...

However, it should be kept in mind that all this research is in the context of sleep deprivation, or circadian dysfunction. In someone who's sleeping normally, many of these things may not happen at all, and the ones that do are probably going to be far more subtle. That said, it has noticeable endurance benefits. Its often sold in pills, but isn't significantly orally bioavailable. You can either inject it intramuscularly, or you could also make a solution for transdermal administration, using a mix of DMSO and ethanol as your solvents.

Something I've been using recently is Methylene Blue. An industrial dye, as well as the very first synthetic medicine in history. Its largely fallen out of medical use, aside from cyanide poisoning, and a few other weird emergency situations. It should be noted that its a mild MAOI, so you should be cautious combining it with other drugs that directly impact neurotransmitters, especially things that really increase serotonin. If you're a baller like me, who goes all in on polypharmacy, it can be done with relatively low risk, you just need to be cautious about slowly titrating doses

Additionally, it causes the Electron Transport Chain to function differently than normal, skipping a few steps in the process, and "leaking" fewer electrons. This seems to cause your body to produce more mitochondria. So now, not only do you have ATP being produced more efficiently than normal, you also have more mitochondria pumping it out for you.

Its not totally clear how much is coming from the MAOI effect, and how much is mitochondrial, but I notice a big difference on it. Started out at 3 mg/day, before titrating up to 5 mg, and then 10 mg. Mood is much more stable and positive. Energy levels are much higher. Significant improvements to endurance. Better sleep, with more vivid dreams.

I've also noticed that my body has gotten much warmer since I've started using it, especially after large meals, where I'll often see temperature go into borderline low grade fever territory. I've also been eating huge amounts of food to maintain my body weight, more than would be expected given my level of activity. To be honest, I think it does have some benefits here, but I'm also using half a dozen other things that could contribute to this, and I think that this specific effect is moreso a synergistic thing than something I'd attribute directly to methylene blue. It might give some amount of help if you're trying to lose weight, but if you started taking it, for the purpose of weight loss, I think you'd probably be pretty disappointed.

Also, it'll make your piss green/blue, depending on the dose. Great party trick tbh. Just be careful, because its a fucking dye, and if you leave a little piss on the toilet seat, it can leave stains behind.

Depending on your age, I'd also potentially be looking at ubiquinol, or coq10. If you're in your early 20s, you might not notice much, or you might be able to get away with coq10. The older you are, the more likely you are to see big benefits, and the more likely you are to need the more expensive form (ubiquinol) for it to work.

I could keep going, there are probably hundreds of great endurance drugs, which have no associated cancer risk, and come with "side effects" of generally improved health. But i think my post is already too long, and people are already going to call me autistic

 

[George Lucas]

My honest advice is to stop popping pills and look at your diet. When I eat a clean diet with a variety of different fruits and vegetables and high in protein (turkey or beef), no coffee, no alcohol, I feel my best and have plenty of energy to get by with six hours of solid sleep. Unfortunately I really like coffee and alcohol so I’m not usually at my best but since I’m retired now that’s fine.

 

[Neurotypical Mantis]

is that like a zooplankton or are they different

 

[666NASTYFUCKINGFREAK666]

My honest advice is to stop popping pills

kill yourself.

 

[Jimjamflimflam]

I took a 16 hour course with this one and got bored a good bit faster as I pointed out earlier in this page, so I took some phenylpiracetam (unknown dose because i didn't have a mg scale lol, prob around 500-800g twice) and managed to kill the remaining 6 hours of video courses in a day (I usually get 2 done with extreme difficulty/boredom issues)

Some questions for you

1) Are you still using it?
2) If so, how much, how often?
3) Any noticeable side effects?
4) Where are you getting it? I just did a quick search and see it on amazon. Is that legit?

 

[666NASTYFUCKINGFREAK666]

Some questions for you

1) Are you still using it?
2) If so, how much, how often?
3) Any noticeable side effects?
4) Where are you getting it? I just did a quick search and see it on amazon. Is that legit?

1: I have no need to use it right now (burnout from doing 5 certs in a year) but I will later.
2: I only used it a few times; finished the entire bottle I believe. My first dose I believe was 150 or 200mg and then i went yolo nigga and started taking 1g doses for a stronger high.
3: Nope.
4: I went to science.bio, they ship to the US. I think the stuff on Amazon is lower-graded stuff I believe.

 

[KillaSmoke]

Some questions for you

1) Are you still using it?
2) If so, how much, how often?
3) Any noticeable side effects?
4) Where are you getting it? I just did a quick search and see it on amazon. Is that legit?

Never buy drugs/supplements from amazon. In this area, quality is always somewhat suspect, even if you're buying directly from a reputable company. When you order something from amazon, regardless of which individual vendor you buy from, amazon just takes everyone who's selling X Brand of Product, throws them into warehouses, and sends you the closest bottle.

Because of this, its very easy to pay some ching-chong a few bucks to make capsules full of sawdust and lead, stuff them into a brands packaging, and sell it as the real thing. Amazon either has no system to track where a specific bottle came from, or they just don't care. Either way, this means the vendor selling counterfeits isn't likely to face any consequence, even if someone does catch it.

I guess source talk isn't allowed here. Not sure if that's a thread rule, or forum rule, and don't want to cause any problems... I'll just say that many drugs sold as nootropic supplements in the US are used as legitimate psychiatric medications, primarily in Russia, or eastern European countries. Particularly with Racetams, there are reputable websites which export these medications to American customers. If you're unfamiliar with a drug, always double check, but many of them are totally unregulated in the US, and can be freely imported with zero legal risk. I suspect the company selling them is probably committing some kind of crime, but that's between them, and whatever Slavic government they're in the jurisdiction of. Not your problem

Back before the racetam market dried up, you could get much lower prices buying from supplement companies, but after the Chinese labs stopped making them, availability went to shit, and prices skyrocketed. I haven't checked to see if that market has bounced back yet, but I wouldn't be surprised if the pharma stuff was reasonably price competitive nowadays

Also, it should be noted by anyone unfamiliar with phenypiracetam that Magnitude's 1 gram doses are absolutely insane. 100-200 mg is much more common, and depending on the person, and what else you take, you can get good effects at 50 mg, or even lower. Not to say I have any problem with him using higher doses... If you've experimented, titrated up the dose, and found something that works well for you, then go for it.... Although anytime you're taking like 5-10x the "normal" dose of something, it might be a good idea to consider whether or not you're using the best drug to get the particular effect that you're looking for.

 

[Jimjamflimflam]

I went to science.bio, they ship to the US. I think the stuff on Amazon is lower-graded stuff I believe.

So trip report

I couldn't find my scale so I did the retarded thing of eyeballing it (getting a scale tomorrow). Would be very surprised if I even hit threshold of 50mg let alone low of 100mg.

Put it under my tongue, tasted absolutely vile. An hour later still tasting it.

Had a fairly active day today so was feeling low when I took it. Currently feeling a bit more energized, enough to take out trash, clean the litter and unload/load the dishwasher when I was originally putting it off tomorrow. Going to get a bit more work I was putting off done and some studying if I'm still feeling it.

Mentally, clear. More structured thinking in I'm going to do A, then B while being chill about

Would recommend after more experimenting.

 

[PointOfNoReturnPoint]

So trip report

I couldn't find my scale so I did the retarded thing of eyeballing it (getting a scale tomorrow). Would be very surprised if I even hit threshold of 50mg let alone low of 100mg.

Put it under my tongue, tasted absolutely vile. An hour later still tasting it.

Had a fairly active day today so was feeling low when I took it. Currently feeling a bit more energized, enough to take out trash, clean the litter and unload/load the dishwasher when I was originally putting it off tomorrow. Going to get a bit more work I was putting off done and some studying if I'm still feeling it.

Mentally, clear. More structured thinking in I'm going to do A, then B while being chill about

Would recommend after more experimenting.

Eyeballing is just going to be inaccurate but you probably didn't take enough if you could fit it under your tongue in powder form, from what I heard from Magnitude is that it is essentially not as dense in that shape so you need physically more, cannot speak on it though cause I didn't use it or have any numbers infront of me to say. You know it is something called fat soluble, meaning it has to bind to fat receptors to really be transferred to your bloodstream. I said it tasted like burnt electricity and so did someone else and you are wondering why it still lingers in your mouth. Bro we might be nuts but we are not stupid liar's. Shit tastes nasty AF. If you eat a single slice of bread that's enough fat to get it to bind but, snorting/sublingual is just not enough. Overall your experience with it is what you should be getting out of it, what you went through is ideal for it's intentions. You are not supposed to be super Mike Tyson aggro but have the negatives shaved off and be able to be liquid essentially.

Overall you got out of this what you should, the liquid form is easier to down cause you can shotgun it with water/milk/everclear or what have you, but congrats, you are slightly less dumb for 4 hours.

 

[PointOfNoReturnPoint]

I guess source talk isn't allowed here. Not sure if that's a thread rule, or forum rule, and don't want to cause any problems...

OP here, I did it so I didn't have any libility if someone did buy something and croaked. I know in the end I didn't have a gun to their head but that 1 ounce of prevention ya know?

Never buy drugs/supplements from amazon. In this area, quality is always somewhat suspect, even if you're buying directly from a reputable company

This is true from what I have heard. If you try to go the cheap route or the generic route in general it can backfire on you or waste your money. You may get lucky but, is this something you want to gamble on?

Also, it should be noted by anyone unfamiliar with phenypiracetam that Magnitude's 1 gram doses are absolutely insane. 100-200 mg is much more common, and depending on the person, and what else you take, you can get good effects at 50 mg, or even lower.

This is true, the madman really went balls to the wall on it and came out the other side going, yeah I'd doing it again. Fuckin mad lad. But, you are right on a serious note that 1g of the stuff is overkill. When he was doing so he had something he had to really mentally be sharp on and in a DM he told me it did make the difference so, take it with a grain of salt that their is a "benefit" but that's the extreme end. This is meant to help you coast through the day super smoothly like jimjam mentioned. I also noticed when I was driving my car and had a near death experience from someone that tried to pass me in my blind spot, when it was all said and done, my pulse didn't even go up and I was in total focus/control the whole time. It wasn't some super power grade of focus but it did prevent any sort of panic or adrenaline rush that would have wired me up. Totally calm, cool and collected.

 

[KillaSmoke]

I recently started donepezil. Its an acetylcholinesterase inhibitor, meaning it prevents the enzyme responsible for breaking down acetylcholine from functioning. Its one of the primary drugs in treatment of Alzheimer's.

While the official medical line is that it only masks symptoms, and doesn't do anything to treat or prevent dementia, they're wrong. They just wait until peoples brains are swiss cheese to start using it. Not to PL too much, but my grandfather has been showing dementia symptoms for years, and his doctors refuse to treat it, because they say its only a "normal" amount of dementia for his age.

The reality is that its been long known that smokers have drastically lower risk of dementia, despite the horrific health impacts of smoking. This is because nicotine has a protective effect, via its agonsism on the nicotinic subtype of acetylcholine receptors. Also, its been shown that chronic use of diphenhydramine (benadryl) is associated with cognitive decline and increased dementia risk, due its antagonism of acetylcholine. So although acetylcholine is certainly only a fraction of the whole picture, its fairly well established that, all else equal, more ACH signalling means lower dementia risk, and less ACH signalling means more dementia risk. So donepezil almost certainly exerts some protective effect.

Started out at 2.5 mg/day, half of the lowest medical dose. I got these weird effervescent tablets, for old people who can't swallow pills, and they were a bitch to split in half. Gave it around a week to hit a stable level, and then waited another week to assess.

Didn't notice much, so went up to a full 5 mg/day. The main thing I've been noticing is that my nicotine sensitivity is through the roof. I use Snus, a Swedish oral tobacco, which isn't associated with cancer. It varies day to day, but let's say I typically use 10-15 portions. After going up to 5 mg, I could tolerate maybe 2 portions per day, and would have to take them out of my mouth, and take breaks before putting them back in. Any more than that, I'd get really overstimulated, and start getting anxiety. This caused some sleep disruption, before I realized how strong of an effect the donepezil was having.

Once I figured it out, I thought I might have to quit the tobacco. Went a few days without using it, without any typical nicotine withdrawal. I just missed having something tasty to play with in my mouth all day. I've been able to slowly bring the Snus back up, and am on about 5 portions/day, which honestly feels stronger than the 10-15 I was doing before. So taking donepezil is actually saving me money, if you think about it

I still want to give myself more time to adjust to it, and I'm messing with some other stuff in the mean time (just started sodium butyrate, planning to add sodium valproate, just increased testosterone from 30 mg/day to 42, etc...) So I want to give all of that time to settle. But in two or three months, I'm thinking I might bring the donepezil up to 10 mg/day. Would probably need to switch to only using tobacco acutely, as needed for specific tasks, rather than all day everyday.

 

[PointOfNoReturnPoint]

You are taking it just to prevent Alzheimer's n quit smoking?

 

[KillaSmoke]

Increased acetylcholine has plenty of benefits outside of that. Its important for focus, memory formation, even muscle contraction. Its why people use tobacco, and why nicotine helps focus. Its also the primary mechanism of action of most -racetams. Sorry, I assumed you guys would be familiar with the basics of ACH, given all the racetam talk. I figured the Alzheimer's prevention would be the most interesting/controversial aspect.

And I use Snus, although I'll occasionally have the odd cigarette in a social situation. Since there's no cancer risk, and my blood pressure is good, I have zero reason to quit. I enjoy it, and would like to keep using it. Being forced to moderate my intake has been the most dramatic effect I've seen from the donepezil, which is why I mentioned it

 

[PointOfNoReturnPoint]

Increased acetylcholine has plenty of benefits outside of that. Its important for focus, memory formation, even muscle contraction. Its why people use tobacco, and why nicotine helps focus. Its also the primary mechanism of action of most -racetams. Sorry, I assumed you guys would be familiar with the basics of ACH, given all the racetam talk. I figured the Alzheimer's prevention would be the most interesting/controversial aspect.

And I use Snus, although I'll occasionally have the odd cigarette in a social situation. Since there's no cancer risk, and my blood pressure is good, I have zero reason to quit. I enjoy it, and would like to keep using it. Being forced to moderate my intake has been the most dramatic effect I've seen from the donepezil, which is why I mentioned it

I only know about what I mentioned and I have a passing interest in them in general but, nah I didn't know anything about ACH. Thanks for thinking I was smart by default tho.

 

[Jimjamflimflam]

Eyeballing is just going to be inaccurate but you probably didn't take enough if you could fit it under your tongue in powder form

Yeah I just got a bit on my finger tip and brushed it under. Could have been placebo effect more then anything (or maybe super effective. Don't know). Figured I might be retarded but better to error on the side of caution.

No jitterness. Didn't wake up with a single spot cleaned after a 10 hour cleaning session. Went through my studies feeling focused and in the zone without grinding teeth and over focused. Slight irritability effect though that make might just been amplified by some practices tests I was taking.

 

[PointOfNoReturnPoint]

Yeah I just got a bit on my finger tip and brushed it under. Could have been placebo effect more then anything (or maybe super effective. Don't know). Figured I might be retarded but better to error on the side of caution.

No jitterness. Didn't wake up with a single spot cleaned after a 10 hour cleaning session. Went through my studies feeling focused and in the zone without grinding teeth and over focused. Slight irritability effect though that though make might just been amplified by some practices tests I was taking.

It will work with what you did, it's just that it's not absorbed that effectively sublingually. Taking something like this slow and safely is at least one thing that you can do as a sure to be safe and smart about it. It was fuckin wild that dude smashed a whole gram and went fuck it, but don't blame yourself for wanting to take it smart.

Yep, that's the entire reason the commies made this. It's more effective than a cup of coffee and wildly more stable with less side effects. They literally designed it to be used in space by astronauts. Sadly it doesn't work for as long as i want, so you have to take multiple doses but making a longer effective version is something idk if anyone will ever do.

I also want you too look into potential anxiety issues with what you described. That's telltale signs of it my man. Stress causes that and it's natural but it can help take the edge off to keep you sharp.

 

[world of shit]

Years ago when you could get them from trustworthy american suppliers, i took pretty much every racetam available, mixing them, adding them with other supplements.

Nothing could touch phenylpiracetam and Modafinil.

I took a long break from them because certain combos could cause a mania/crash.

Anything newer or better nowadays?

 

[PointOfNoReturnPoint]

Years ago when you could get them from trustworthy american suppliers, i took pretty much every racetam available, mixing them, adding them with other supplements.

Nothing could touch phenylpiracetam and Modafinil.

I took a long break from them because certain combos could cause a mania/crash.

Anything newer or better nowadays?

Not that I know of no, until the near future i am broke so no idea on them tbh.