Cr1ms0n_&_C10v3r
kiwifarms.net
- Joined
- Feb 17, 2019
Luckily when it comes to selectively breeding mutants, some popular domestic species are relatively unscathed. Guinea pigs are an example of this, they have their issues but they're relatively long-lived rodents, making it consistently to around 6 if in good health (my oldest guinea pig was almost 9).
There are some genetic defects that result not directly from selective breeding but by recessive genes that create certain coat colours. In guinea pigs this is roan and Dalmatian:
Dalmatians have a particular pattern of spotting as you can see, "roan" is when you have white hairs evenly dispersed amongst black hairs.
You cannot breed a roan to a roan, a Dalmatian to a Dalmatian, or a roan to a Dalmatian. This is because if a guinea pig receives 2 copies of the recessive gene that causes these coat colours, and if it's born alive, it will be what's called a "lethal white". With these pairings there is always a 25% chance of any offspring being a lethal white. Here's some pics of them:
(This one has a head tilt probably due to blindness)
Whilst they aren't visibly SMASHED and SLAMMED, they're pretty disabled. They produce no pigment and so are always albino. They have underdeveloped and occasionally missing/no eyes, are usually totally deaf and blind, have underdeveloped or missing/no teeth, underdeveloped jaws, and GI tract/internal organ deformities. They also have a reduced lifespan. Because of their tooth and jaw issues, if you want to keep one alive, it will require syringe feeding for life (guinea pigs constantly graze so this isn't an easy task), or specialised food in tiny or soft pieces. They often can't absorb nutrients properly because of their GI tract deformities so their growth is often stunted and sometimes they just starve to death. They can technically survive with a good enough quality of life, as some lethals are more functioning than others, but they're all fucked up to a degree.
The understanding is that basically the recessive gene that causes the roan and Dalmatian coat colours is directly involved with pigment production and the formation of neurons and nerves in a foetal guinea pig. This is why they are almost always deaf and blind with various underdeveloped organs.
There's a similar condition in horses associated with the frame overo pattern although it's slightly different in that the coat colour doesn't guarantee carrying the recessive gene, and the foals are born relatively normal except all white, but die or must be euthanised as they have a non-functioning lower GI tract.
There are some genetic defects that result not directly from selective breeding but by recessive genes that create certain coat colours. In guinea pigs this is roan and Dalmatian:
Dalmatians have a particular pattern of spotting as you can see, "roan" is when you have white hairs evenly dispersed amongst black hairs.
You cannot breed a roan to a roan, a Dalmatian to a Dalmatian, or a roan to a Dalmatian. This is because if a guinea pig receives 2 copies of the recessive gene that causes these coat colours, and if it's born alive, it will be what's called a "lethal white". With these pairings there is always a 25% chance of any offspring being a lethal white. Here's some pics of them:
(This one has a head tilt probably due to blindness)
Whilst they aren't visibly SMASHED and SLAMMED, they're pretty disabled. They produce no pigment and so are always albino. They have underdeveloped and occasionally missing/no eyes, are usually totally deaf and blind, have underdeveloped or missing/no teeth, underdeveloped jaws, and GI tract/internal organ deformities. They also have a reduced lifespan. Because of their tooth and jaw issues, if you want to keep one alive, it will require syringe feeding for life (guinea pigs constantly graze so this isn't an easy task), or specialised food in tiny or soft pieces. They often can't absorb nutrients properly because of their GI tract deformities so their growth is often stunted and sometimes they just starve to death. They can technically survive with a good enough quality of life, as some lethals are more functioning than others, but they're all fucked up to a degree.
The understanding is that basically the recessive gene that causes the roan and Dalmatian coat colours is directly involved with pigment production and the formation of neurons and nerves in a foetal guinea pig. This is why they are almost always deaf and blind with various underdeveloped organs.
There's a similar condition in horses associated with the frame overo pattern although it's slightly different in that the coat colour doesn't guarantee carrying the recessive gene, and the foals are born relatively normal except all white, but die or must be euthanised as they have a non-functioning lower GI tract.
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