Community Tard Baby General (includes brain dead kids) - Fundies and their genetic Fuckups; Parents of corpses in denial

[Crimewatcher 44]

I think it's unethical to knowingly pass on any genetic disorder or deformity. They could have selected normal embryos. That would have been the only ethical choice. Think of it how vets talk about SMASHED and SLAMMED animals. Lots of people like the look of dwarf animals and brachycephalic breeds. They think it's cute but most professionals consider it animal cruelty to breed them. It should be considered the same with humans. You have to think, not just of how society currently is, but how these people would fare if society collapsed. Could they survive without modern medical care?

She might have had HCM- hypertrophic cardiomyopathy. It's the most common case of sudden cardiac death in young healthy athletes. Not sure about healthy young non-athletes but probably.

Even if disabled people quit having children, we'd still have genetic disorders. No one in my family has a genetic disorder, not my parents, grandparents, or great-grandparents. Hell, going back several more generations everyone was healthy, except for me. My disorder was the result of a spontaneous genetic mutation. Conception is a fragile, imperfect process and shit happens. My parents were young and healthy.

 

[Thomas Eugene Paris]

Cats too.

Not to be a pedant, but this isn't exactly accurate.

Spoiler: WELL, ACKSHYUALLY

Down syndrome is really just a name for a collection of observable signs which result from trisomy 21, which means that a person has three copies of chromosome 21 in all or some of their cells rather than the usual two. Cats don't have a 21st chromosome, so while they can have other genetic abnormalities which result in signs similar to those observed in humans with Down syndrome, they cannot, by definition, have trisomy 21.

Mice also lack a 21st chromosome. All of the existing and past "mouse models" of Down syndrome have mutations on chromosome 16, which is analogous to human chromosome 21. However, there are differences in gene distribution between murine chromosome 16 and human chromosome 21, and true trisomy 16 is embryonic lethal in mice. This means that most pups die before birth, making the Ts16 mouse model, developed in the late 1970s, an impractical choice for research, which requires the reliable breeding of large numbers of mice. Subsequent models have been refined so that only small regions of the chromosome, containing specific genes relevant to human Down syndrome are triplicated, so the mice are a better model.

Even so, no single mouse model exhibits all the signs of human trisomy 21. Researchers pick a model based on the area of Down syndrome development they are investigating. For example, a researcher interested in how people with DS learn might pick a different model than one who is studying the association between trisomy 21 and leukemia.

I could probably sperg more about this, but I'll leave it at that for now since literally nobody asked. I will say that difficulty getting a particular strain to breed is a major obstacle in research.

 

[booklover]

This thread is getting a real “Flowers for Algernon” vibe to it today.

alzheimer's Is more prevalent in people with Down’s due to a few extra shitty mutations in their DNA. It’s all early onset and they can develop the disease in their early 40s. Activists with Down’s are at the forefront of Alzheimer’s awareness, so they are all doing good work.
That said, drugs aren’t developed solely in mice, even Down’s mice, and there would be several clinical trials before a medicine hit the shelves.

Happily, it looks like there has been a recent, and accidental breakthrough. With Viagra.

https://www.nih.gov/news-events/nih-research-matters/viagra-associated-reduced-risk-alzheimers-disease

Not surprising, because Viagra does promote blood flow.

 

[Jeep1971]

Not to be a pedant, but this isn't exactly accurate.

Spoiler: WELL, ACKSHYUALLY

Down syndrome is really just a name for a collection of observable signs which result from trisomy 21, which means that a person has three copies of chromosome 21 in all or some of their cells rather than the usual two. Cats don't have a 21st chromosome, so while they can have other genetic abnormalities which result in signs similar to those observed in humans with Down syndrome, they cannot, by definition, have trisomy 21.

Mice also lack a 21st chromosome. All of the existing and past "mouse models" of Down syndrome have mutations on chromosome 16, which is analogous to human chromosome 21. However, there are differences in gene distribution between murine chromosome 16 and human chromosome 21, and true trisomy 16 is embryonic lethal in mice. This means that most pups die before birth, making the Ts16 mouse model, developed in the late 1970s, an impractical choice for research, which requires the reliable breeding of large numbers of mice. Subsequent models have been refined so that only small regions of the chromosome, containing specific genes relevant to human Down syndrome are triplicated, so the mice are a better model.

Even so, no single mouse model exhibits all the signs of human trisomy 21. Researchers pick a model based on the area of Down syndrome development they are investigating. For example, a researcher interested in how people with DS learn might pick a different model than one who is studying the association between trisomy 21 and leukemia.

I could probably sperg more about this, but I'll leave it at that for now since literally nobody asked. I will say that difficulty getting a particular strain to breed is a major obstacle in research.

Thank you for the information, I've seen photos of cats with obvious facial features of a chromosomal disorder. I never knew they couldn't get Downs.

 

[Garbage.Theory]

Not to be a pedant, but this isn't exactly accurate.

Spoiler: WELL, ACKSHYUALLY

Down syndrome is really just a name for a collection of observable signs which result from trisomy 21, which means that a person has three copies of chromosome 21 in all or some of their cells rather than the usual two. Cats don't have a 21st chromosome, so while they can have other genetic abnormalities which result in signs similar to those observed in humans with Down syndrome, they cannot, by definition, have trisomy 21.

Mice also lack a 21st chromosome. All of the existing and past "mouse models" of Down syndrome have mutations on chromosome 16, which is analogous to human chromosome 21. However, there are differences in gene distribution between murine chromosome 16 and human chromosome 21, and true trisomy 16 is embryonic lethal in mice. This means that most pups die before birth, making the Ts16 mouse model, developed in the late 1970s, an impractical choice for research, which requires the reliable breeding of large numbers of mice. Subsequent models have been refined so that only small regions of the chromosome, containing specific genes relevant to human Down syndrome are triplicated, so the mice are a better model.

Even so, no single mouse model exhibits all the signs of human trisomy 21. Researchers pick a model based on the area of Down syndrome development they are investigating. For example, a researcher interested in how people with DS learn might pick a different model than one who is studying the association between trisomy 21 and leukemia.

I could probably sperg more about this, but I'll leave it at that for now since literally nobody asked. I will say that difficulty getting a particular strain to breed is a major obstacle in research.

I for one love your science spergs. They are a delight in this otherwise grim thread.

Have a link to KOMP and science on you autistic dork you.

https://www.mmrrc.org/catalog/StrainCatalogSearchForm.php?search_query=KOMP%20Repository

 

[Sparkling Yuzu]

I thought thanatophoric dysplasia was a form of dwarfism unrelated to achondroplasia that can occur randomly, rather than “double dwarfism” as you’re saying?

I think a medfag explained the thanato type is located on a different part of the gene that causes double dwarfism. You can certainly have dwarfism with normal parents. I think genetic screening should be done on everyone, able bodied or not and embryo selection should be covered by healthcare if there's a chance for a child to be affected. We'd end up saving more money by preventing lifelong disability.

They were really lucky not to do that, because they were very upfront that they would terminate if tests at 20 weeks showed that. Risky odds.

um wtf, that's based. i love dwarf parents now

Even if disabled people quit having children, we'd still have genetic disorders. No one in my family has a genetic disorder, not my parents, grandparents, or great-grandparents. Hell, going back several more generations everyone was healthy, except for me. My disorder was the result of a spontaneous genetic mutation. Conception is a fragile, imperfect process and shit happens. My parents were young and healthy.

I agree with you and really disability itself is not good enough to go off of due to the huge number of causes. I think they should screen for do novo mutations too, ideally before the fetus is too old and give the option to abort.

Not to be a pedant, but this isn't exactly accurate.

Spoiler: WELL, ACKSHYUALLY

Down syndrome is really just a name for a collection of observable signs which result from trisomy 21, which means that a person has three copies of chromosome 21 in all or some of their cells rather than the usual two. Cats don't have a 21st chromosome, so while they can have other genetic abnormalities which result in signs similar to those observed in humans with Down syndrome, they cannot, by definition, have trisomy 21.

Mice also lack a 21st chromosome. All of the existing and past "mouse models" of Down syndrome have mutations on chromosome 16, which is analogous to human chromosome 21. However, there are differences in gene distribution between murine chromosome 16 and human chromosome 21, and true trisomy 16 is embryonic lethal in mice. This means that most pups die before birth, making the Ts16 mouse model, developed in the late 1970s, an impractical choice for research, which requires the reliable breeding of large numbers of mice. Subsequent models have been refined so that only small regions of the chromosome, containing specific genes relevant to human Down syndrome are triplicated, so the mice are a better model.

Even so, no single mouse model exhibits all the signs of human trisomy 21. Researchers pick a model based on the area of Down syndrome development they are investigating. For example, a researcher interested in how people with DS learn might pick a different model than one who is studying the association between trisomy 21 and leukemia.

I could probably sperg more about this, but I'll leave it at that for now since literally nobody asked. I will say that difficulty getting a particular strain to breed is a major obstacle in research.

I think people took the downie tiger thing literally but if you ask a vet they will say it's just a similar phenotype, not literal DS.

Not surprising, because Viagra does promote blood flow.

It sounds like it would help vascular dementia more than Alzheimer's with those nasty plaques.

 

[Everything Beagle]

The mucous layer dies first because it isn't being renewed, but if there's blood flow and some parasympathetic nervous system activity.... it might keep regenerating.https://www.nbcnews.com/id/wbna39632040

We can look to history and isolated groups. Any child that was a spud who couldn't contribute to the group would be tossed to the curb. Anything too deformed would be put down at birth.

But also...

Some neanderthals took care of their disabled friend for years.
https://www.ancient-origins.net/news-history-archaeology/neanderthals-took-care-deaf-and-disabled-buddy-until-old-age-009023

And so did some early humans. This kid might not have made it to 10 years old even today.
https://www.discovermagazine.com/pl...k-care-of-the-disabled-over-500-000-years-ago

This kid had it really hard, but they raised him as long as they could.
https://www.nytimes.com/2012/12/18/science/ancient-bones-that-tell-a-story-of-compassion.html

Plus an old (ish) guy!
https://www.nbcnews.com/id/wbna39632040

That's it, that's all my sperging for today.

 

[Bizzy Bee]

https://www.instagram.com/p/CfxRErXJ5LZ/?igshid=NWRhNmQxMjQ=

Another trigger for my Paisley-induced nausea.
Behold.

 

[GenociderSyo]

 

[Fartificial Insmelligence]

None of the autists here would even exist.

You say that like it's a bad thing!

 

[Sparkling Yuzu]

https://www.instagram.com/p/CfxRErXJ5LZ/?igshid=NWRhNmQxMjQ=

Another trigger for my Paisley-induced nausea.
Behold.

It's not very flattering to adorn one of the most freakish parts of her like that. Her thumbnail is overgrown too. I bet that bracelet feels crappy and scratchy, since it's made of cheap plastic beads. A regular girl might be able to tolerate it if she finds it pretty, but they should give Paisley something like sensory jewelry that feels nice.
It's kind of disturbing how much they could do to enrich the one life she'll ever experience but they force her to do things like go in snow and wear uncomfortable jewelry she'll never be able to experience any pleasure from. I think she might be able to learn basic communication, but no one cares to try. Could she do simplified signs with her stubby lil arms and hands? lol

 

[GenociderSyo]

Could she do simplified signs with her stubby lil arms and hands? lol

Yes. The modified sign language used for non-verbal delayed children/adults does not require fine motor skills. We teach it to children who probably are lower functioning then Paisley is.

 

[Bizzy Bee]

Yes. The modified sign language used for non-verbal delayed children/adults does not require fine motor skills. We teach it to children who probably are lower functioning then Paisley is.

Such a shame for her. Her weirdo parents don’t seem to do anything enriching with her/for her. They also randomly post things like “people say we just leave her laying down all the time but we do lots with her”. Mmm hmm, sure you do. In psychiatry we call this ‘reaction formation’. In others words, they who doth protest too much….

 

[son of jurassic bark]

But also...

Some neanderthals took care of their disabled friend for years.
https://www.ancient-origins.net/news-history-archaeology/neanderthals-took-care-deaf-and-disabled-buddy-until-old-age-009023

And so did some early humans. This kid might not have made it to 10 years old even today.
https://www.discovermagazine.com/pl...k-care-of-the-disabled-over-500-000-years-ago

This kid had it really hard, but they raised him as long as they could.
https://www.nytimes.com/2012/12/18/science/ancient-bones-that-tell-a-story-of-compassion.html

Plus an old (ish) guy!
https://www.nbcnews.com/id/wbna39632040

That's it, that's all my sperging for today.

I always loved reading about that, also people who buried disabled group members with the same regard given to the able-bodied.

 

[Sparkling Yuzu]

Yes. The modified sign language used for non-verbal delayed children/adults does not require fine motor skills. We teach it to children who probably are lower functioning then Paisley is.

So they can spend their grifted money on stupid consoomer shit but not something that might make Paisley's difficult life a bit more bearable. She seems to cry and attempt to vocalize a lot. At least allow her the ability to express her discomfort, like god damn.
I'm sure SLP, OT and PT would all have benefits, it's not like literal potatoes where there is no hope of improving their life in any way. It was sad to see Claire and Lola get all those expensive in-home therapies that they would never benefit from. Paisley might cry less if she can say she's hungry, needs to be changed etc. I bet she would've said she hated being put in the snow if she could have. Like signing "no snow!".

 

[GenociderSyo]

So they can spend their grifted money on stupid consoomer shit but not something that might make Paisley's difficult life a bit more bearable. She seems to cry and attempt to vocalize a lot. At least allow her the ability to express her discomfort, like god damn.
I'm sure SLP, OT and PT would all have benefits, it's not like literal potatoes where there is no hope of improving their life in any way. It was sad to see Claire and Lola get all those expensive in-home therapies that they would never benefit from. Paisley might cry less if she can say she's hungry, needs to be changed etc. I bet she would've said she hated being put in the snow if she could have. Like signing "no snow!".

It be moreso signs for No, Yes, Bathroom, More, Stop, Food. Very simple words.

 

[Thomas Eugene Paris]

Not surprising, because Viagra does promote blood flow.

Pfizer actually discovered sildenafil (Viagra) while trying to develop a drug to treat angina, the pain caused by coronary artery disease. In addition to its widely known use, it is also FDA approved for the treatment of pulmonary arterial hypertension, high blood pressure in the arteries which carry deoxygenated blood from the right ventricle of the heart to the lungs.

Spoiler: Blah blah blah muh angiogenesis

Very premature infants have underdeveloped lungs and often require prolonged mechanical ventilation. Both prematurity itself and the chronic acquired pulmonary injury caused by invasive ventilation prevent the lungs and their blood vessels normally, causing a cascade of effects which ultimately result in too much pressure in the pulmonary arteries. Pulmonary hypertension is a major contributor to mortality and morbidity in premature babies, and I actually think at least a couple of the Tard Babies have had it. This is a great article if you're interested.

Anyway, guess what is used to treat PH in tiny premature babies? That's right, sildenafil! Imagine being the parent of a 500 gram newborn, who is in intensive care on a ventilator, and the neonatologist is like, "Yo, time to bust out the Viagra, amirite?!" I have a family member who worked in a NICU, and the first time she had to call the pharmacy about Viagra for a premature baby she froke out thinking the doctor just had zero clue what he was doing.

I for one love your science spergs. They are a delight in this otherwise grim thread.

Have a link to KOMP and science on you autistic dork you.

https://www.mmrrc.org/catalog/StrainCatalogSearchForm.php?search_query=KOMP%20Repository

You know the way to my heart.

Here's a fave: Mouse Genome Informatics

 

[Sparkling Yuzu]

It be moreso signs for No, Yes, Bathroom, More, Stop, Food. Very simple words.

That would be great I think. It would be a big improvement to only being able to cry, make faces and blow bubbles.

 

[Bizzy Bee]

That would be great I think. It would be a big improvement to only being able to cry, make faces and blow bubbles.

Don’t forget the tongue thrusting. About which the mother usually writes “sassy girl”

 

[Jeep1971]

Don’t forget the tongue thrusting. About which the mother usually writes “sassy girl”

I just hate when they dress her in costumes and use her as a prop for social media. She always looks like she's in severe discomfort.